PKIA and AGFG1

Number of citations of the paper that reports this interaction (PMID 8805303)
36

Data Source:
HPRD (two hybrid)

		PKIA	AGFG1
Gene Name		protein kinase (cAMP-dependent, catalytic) inhibitor alpha	ArfGAP with FG repeats 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nuclear Pore Cytoplasmic Membrane-bounded Vesicle Cell Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding Protein Kinase A Catalytic Subunit Binding	DNA Binding RNA Binding Protein Binding ARF GTPase Activator Activity Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of CAMP-dependent Protein Kinase Activity	Acrosome Assembly MRNA Export From Nucleus Multicellular Organismal Development Spermatid Nucleus Differentiation Regulation Of ARF GTPase Activity Positive Regulation Of GTPase Activity Intermediate Filament Organization
Pathways
Drugs
Diseases
GWAS		Bone mineral density ( 22504420) Multiple sclerosis ( 21833088) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		8 interactors: AGFG1 DYNLL1 EGFR JUNB PRKACA PRKACB PRKX XPO1	11 interactors: APC APP EPS15 EPS15L1 ITSN1 NYAP2 PKIA POLE2 RNF216 VAMP7 XPO1
Entrez ID		5569	3267
HPRD ID		05828	02918
Ensembl ID		ENSG00000171033	ENSG00000173744
Uniprot IDs		P61925	P52594
PDB IDs		1CMK 1JLU 1Q8T 1VEB 1XH4 1XH5 1XH6 1XH7 1XH8 1XH9 1XHA 1YDR 2C1A 2C1B 2F7E 2GNI 2JDS 2JDT 2JDV 2L1L 2UVX 2UVY 2UVZ 2UW0 2UW3 2UW4 2UW5 2UW6 2UW7 2UW8 2VNW 2VNY 2VO0 2VO3 2VO6 2VO7 3AMA 3AMB 3L9L 3L9M 3L9N 3MVJ 3NX8 3OOG 3OVV 3OWP 3OXT 3P0M 3POO 3VQH 4AXA 4IAC 4IAD 4IAF 4IAI 4IAK 4IAY 4IAZ 4IE9 4IJ9	2D9L 2OLM 2VX8
Enriched GO Terms of Interacting Partners?		Cellular Response To Growth Factor Stimulus Activation Of Phospholipase C Activity Response To Growth Factor Positive Regulation Of Phospholipase C Activity Anatomical Structure Morphogenesis Regulation Of Establishment Of Protein Localization Positive Regulation Of Phospholipase Activity Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Regulation Of Protein Localization Multicellular Organismal Reproductive Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Multicellular Organism Reproduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Tube Morphogenesis Regulation Of Intracellular Transport Regulation Of Cellular Localization Reproduction Anatomical Structure Formation Involved In Morphogenesis Activation Of Protein Kinase A Activity Morphogenesis Of An Epithelium Immune System Process Single Organism Reproductive Process Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Triglyceride Catabolic Process Cellular Response To Hormone Stimulus Reproductive Process Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Protein Export From Nucleus Regulation Of Protein Transport Acylglycerol Catabolic Process Regulation Of Nucleocytoplasmic Transport Tissue Morphogenesis Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Renal Water Homeostasis Negative Regulation Of Embryonic Development Neurotrophin Signaling Pathway Tube Development Negative Regulation Of Smoothened Signaling Pathway Developmental Process Involved In Reproduction Positive Regulation Of Intracellular Transport Regulation Of Signal Transduction Mitotic Cell Cycle Regulation Of Intracellular Protein Transport Mitotic Cell Cycle Phase Transition	Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Endocytosis Regulation Of Cell Cycle Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Signaling Regulation Of Cell Cycle Phase Transition Neuron Projection Morphogenesis Regulation Of Intracellular Protein Transport Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Regulation Of Protein Localization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Protein Targeting To Vacuolar Membrane Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Regulation Of Signal Transduction Neuron Development Apoptotic Process Post-Golgi Vesicle-mediated Transport Regulation Of Mitotic Cell Cycle Programmed Cell Death Regulation Of Intracellular Transport Regulation Of Cellular Localization Synaptic Growth At Neuromuscular Junction Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Cell Death Death Cell Morphogenesis Negative Regulation Of Signal Transduction Establishment Of Localization In Cell Neuron Differentiation Cell Surface Receptor Signaling Pathway Cell Projection Organization Ribosomal Small Subunit Export From Nucleus Positive Regulation Of Histamine Secretion By Mast Cell Regulation Of Histamine Secretion By Mast Cell Eosinophil Degranulation Collateral Sprouting In Absence Of Injury Triglyceride Transport Negative Regulation Of Signaling Axonogenesis Regulation Of Microtubule Cytoskeleton Organization Response To Stimulus Negative Regulation Of Protein Serine/threonine Kinase Activity
Tagcloud ?		acetaminophen alanine apap attenuation comparing corroborated determining differently discover dismutase exacerbation forty glutathione grouped hepatotoxicity peroxidase peroxynitrite pka potentiated pretreatment reflecting screen serious severity sought substantial superoxide susceptible transaminase
Tagcloud (Difference) ?		acetaminophen alanine apap attenuation comparing corroborated determining differently discover dismutase exacerbation forty glutathione grouped hepatotoxicity peroxidase peroxynitrite pka potentiated pretreatment reflecting screen serious severity sought substantial superoxide susceptible transaminase
Tagcloud (Intersection) ?