SKAP1 and PTPRC

Number of citations of the paper that reports this interaction (PMID 11909961)
8

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (in vitro, in vivo, two hybrid)

		SKAP1	PTPRC
Gene Name		src kinase associated phosphoprotein 1	protein tyrosine phosphatase, receptor type, C
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Cell-cell Junction	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding Protein Complex Binding SH2 Domain Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Protein Kinase Binding
	Biological Process	Positive Regulation Of Signal Transduction Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter T Cell Receptor Signaling Pathway	Negative Regulation Of T Cell Mediated Cytotoxicity Negative Regulation Of Cytokine-mediated Signaling Pathway Hematopoietic Progenitor Cell Differentiation Immunoglobulin Biosynthetic Process Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Cell Surface Receptor Signaling Pathway Axon Guidance Dephosphorylation T Cell Differentiation Positive Regulation Of B Cell Proliferation Peptidyl-tyrosine Dephosphorylation B Cell Proliferation Positive Regulation Of T Cell Proliferation Cell Cycle Phase Transition Positive Regulation Of Protein Kinase Activity Bone Marrow Development Stem Cell Development T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Regulation Of Cell Cycle Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of Stem Cell Proliferation
Pathways			TCR signaling Axon guidance Semaphorin interactions Other semaphorin interactions Phosphorylation of CD3 and TCR zeta chains Adaptive Immune System
Drugs
Diseases
GWAS		Epilepsy (generalized) ( 22949513) Ovarian cancer ( 20852632)	Mean corpuscular hemoglobin ( 20139978)
Protein-Protein Interactions		12 interactors: APP BLCAP FAM102A FYB FYN GRB2 LCK LYN PRAM1 PTPRC SH2D4A SRC	43 interactors: ANP32A CD1D CD2 CD22 CD247 CD28 CD4 CD8A CSNK2A1 CSNK2A2 CXCR4 DPP4 EZR FCGR3A FYN GANAB GRB2 IFNAR1 INSR IRS1 ITGAL JAK1 JAK2 JAK3 LCK LCP2 LGALS1 LSM1 LYN MBL2 PAEP PPFIA1 PPFIBP2 PRKCSH PTPN6 PTPRCAP RASA1 RNF11 SEMA4D SKAP1 TYK2 UHRF2 ZAP70
Entrez ID		8631	5788
HPRD ID		05396	01050
Ensembl ID		ENSG00000141293	ENSG00000081237
Uniprot IDs		Q86WV1	M9MML4 P08575
PDB IDs		1U5D	1YGR 1YGU
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Platelet Activation T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Immune Response-regulating Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Peptidyl-tyrosine Autophosphorylation Cell Activation Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Lymphocyte Activation Axon Guidance Blood Coagulation Hemostasis Regulation Of Immune Response Regulation Of Cell Activation Positive Regulation Of Immune System Process Leukocyte Migration Axonogenesis Axon Development Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Response To Abiotic Stimulus Fc Receptor Signaling Pathway Wound Healing Chemotaxis Regulation Of Cell Adhesion Neuron Projection Morphogenesis T Cell Receptor Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Locomotion Response To Wounding Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Cell Morphogenesis Involved In Differentiation Immune Response Regulation Of Immune System Process Immune System Process Defense Response Innate Immune Response Neuron Projection Development Cell Migration Cell Projection Morphogenesis Regulation Of Phosphorus Metabolic Process	Regulation Of Immune System Process Regulation Of Immune Response Positive Regulation Of Cell Activation Immune Response Immune System Process Defense Response Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Innate Immune Response Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion Peptidyl-tyrosine Autophosphorylation Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell Activation Leukocyte Activation Regulation Of Lymphocyte Activation T Cell Costimulation Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Homotypic Cell-cell Adhesion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Leukocyte Aggregation Locomotion Lymphocyte Activation Single Organismal Cell-cell Adhesion Cell Surface Receptor Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Response To Stress Immune Response-regulating Signaling Pathway Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Immune Response Cell Adhesion Signaling Response To Stimulus Regulation Of Signal Transduction Cell Communication T Cell Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Positive Regulation Of Intracellular Signal Transduction
Tagcloud ?		10kb appbp2 arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4	abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv
Tagcloud (Difference) ?		10kb appbp2 arhgap32 bcas3 breakpoints ccdc49 coamplification col14a1 coregulator ddx5 depdc6 deptor enpp2 hoxb9 lasp1 leukaemias nrip1 oprd1 painting pcgf2 phf20l1 plec1 taok1 tiam1 timm23 trps1 unamplified usp32 zmym4	abl adaptor bcr cd45 chemistry cief cml combines crkl describes detect example focusing isoelectric limit linking lysate nanocapillary nanogram nl pg protocol ptyr207 quantities reproducible screen throughput tkis uv
Tagcloud (Intersection) ?