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SKAP1 and PRAM1
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
SKAP1
PRAM1
Description
src kinase associated phosphoprotein 1
PML-RARA regulated adaptor molecule 1
Image
No pdb structure
GO Annotations
Cellular Component
Immunological Synapse
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Membrane
T Cell Receptor Complex
Plasma Membrane Raft
Plasma Membrane
Protein-containing Complex
Molecular Function
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Protein Phosphatase Binding
SH2 Domain Binding
Protein Binding
Lipid Binding
Protein Kinase Binding
Biological Process
Positive Regulation Of Cell-matrix Adhesion
Adaptive Immune Response
Immune System Process
Positive Regulation Of Adaptive Immune Response
Positive Regulation Of Integrin Activation
Positive Regulation Of Cell-cell Adhesion Mediated By Integrin
Positive Regulation Of Heterotypic Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Protein Localization To Plasma Membrane
Positive Regulation Of Leukocyte Cell-cell Adhesion
Integrin-mediated Signaling Pathway
Regulation Of Neutrophil Degranulation
T Cell Receptor Signaling Pathway
Protein Localization To Plasma Membrane
Pathways
Drugs
Diseases
GWAS
Body mass index (
25673413
28892062
)
Endometrial cancer (
30093612
)
Endometrial cancer (endometrioid histology) (
30093612
)
Epithelial ovarian cancer (
25581431
)
Food allergy (
29030101
)
Generalized epilepsy (
22949513
)
HDL cholesterol levels (
32203549
)
Intelligence (
28530673
)
Keratoconus (
33649486
)
Lean body mass (
28552196
)
Lipid traits (pleiotropy) (HIPO component 1) (
30289880
)
Ovarian cancer (
20852632
)
Peanut allergy (
29030101
)
Pulse pressure (
30578418
)
White blood cell count (
32888494
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Coronary artery disease (
29212778
)
Height (
18391951
)
Interacting Genes
13 interacting genes:
APP
BLCAP
DYNLL2
EEIG1
FYB1
FYN
GRB2
LCK
LYN
PRAM1
PTPRC
SH2D4A
SRC
26 interacting genes:
A2M
ABI2
APOE
APP
BCAR1
CCDC57
CDC37
CEBPA
FXR1
FXR2
GOLGA2
KRT40
LCP2
LYN
MAST1
MXD1
NEDD9
NEK6
PSEN1
RNF32
SH3RF1
SKAP1
SKAP2
TP53BP2
TRIM27
UBE2E2
Entrez ID
8631
84106
HPRD ID
05396
05926
Ensembl ID
ENSG00000141293
ENSG00000133246
Uniprot IDs
Q86WV1
V9HW03
Q96QH2
PDB IDs
1U5D
Enriched GO Terms of Interacting Partners
?
Ephrin Receptor Binding
Antigen Receptor-mediated Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-activating Signaling Pathway
Membrane Raft
T Cell Costimulation
Immune Response-regulating Signaling Pathway
Activation Of Immune Response
Positive Regulation Of Immune System Process
Signaling Receptor Binding
Positive Regulation Of Cell Activation
Regulation Of Immune Response
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Immune Response
T Cell Receptor Signaling Pathway
Signaling Receptor Activator Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Positive Regulation Of T Cell Activation
Regulation Of Immune System Process
Phospholipase Activator Activity
Positive Regulation Of Leukocyte Cell-cell Adhesion
Peptidyl-tyrosine Phosphorylation
B Cell Receptor Signaling Pathway
Fc Receptor Signaling Pathway
Leukocyte Activation
Positive Regulation Of Cell-cell Adhesion
Positive Regulation Of Lymphocyte Activation
Scaffold Protein Binding
Immune System Process
Regulation Of Cell Activation
Regulation Of Leukocyte Cell-cell Adhesion
Cell Activation
Regulation Of T Cell Activation
Stimulatory C-type Lectin Receptor Signaling Pathway
Phospholipase Binding
Cellular Response To Lectin
Cell Surface Receptor Signaling Pathway
Negative Regulation Of Immune Response
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Positive Regulation Of Cell Adhesion
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of Cell-cell Adhesion
Regulation Of Lymphocyte Activation
Negative Regulation Of Defense Response
Protein Tyrosine Kinase Activity
CD8 Receptor Binding
Growth Factor Receptor Binding
Regulation Of Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Amyloid Fibril Formation
Positive Regulation Of Catabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Long-term Synaptic Potentiation
SH3 Domain Binding
Regulation Of Dendritic Spine Maintenance
Regulation Of Immune System Process
Regulation Of Neuronal Synaptic Plasticity
Regulation Of Postsynapse Organization
Lipoprotein Particle
Regulation Of Amyloid Fibril Formation
Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Supramolecular Fiber Organization
Regulation Of Immune Response
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Regulation Of Long-term Neuronal Synaptic Plasticity
Positive Regulation Of Proteolysis
Regulation Of Synaptic Plasticity
Astrocyte Activation Involved In Immune Response
Positive Regulation Of Protein Catabolic Process
Intermediate-density Lipoprotein Particle
Positive Regulation Of Dendritic Spine Maintenance
Growth Factor Receptor Binding
T Cell Receptor Signaling Pathway
Memory
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Long-term Synaptic Potentiation
Cytoplasm
Learning Or Memory
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cellular Response To Amyloid-beta
Signaling Receptor Activator Activity
Regulation Of Amyloid Precursor Protein Catabolic Process
Cytoskeleton Organization
Regulation Of Synapse Organization
Cytosol
Supramolecular Fiber Organization
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Positive Regulation Of Immune System Process
Cognition
Positive Regulation Of Phosphate Metabolic Process
Response To Amyloid-beta
Neuron Projection
Positive Regulation Of Metabolic Process
Regulation Of Defense Response
Intracellular Signal Transduction
Regulation Of Phosphorus Metabolic Process
Neuron Projection Maintenance
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Tagcloud (Difference)
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Tagcloud (Intersection)
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