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RUNX1 and CBFA2T2
Number of citations of the paper that reports this interaction (PMID
10675041
)
5
Data Source:
HPRD
(in vitro)
RUNX1
CBFA2T2
Gene Name
runt-related transcription factor 1
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Basement Membrane
Nucleus
Nucleoplasm
Cytoplasm
Intracellular Membrane-bounded Organelle
Nucleus
Molecular Function
Regulatory Region DNA Binding
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Transcription Factor Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Repressing Transcription Factor Binding
Sequence-specific DNA Binding Transcription Factor Activity
Transcription Corepressor Activity
Protein Binding
Metal Ion Binding
Biological Process
Skeletal System Development
In Utero Embryonic Development
Liver Development
Myeloid Progenitor Cell Differentiation
Transcription, DNA-templated
Central Nervous System Development
Regulation Of Signal Transduction
Hemopoiesis
Myeloid Cell Differentiation
Negative Regulation Of Granulocyte Differentiation
Positive Regulation Of Granulocyte Differentiation
Hair Follicle Morphogenesis
Embryonic Hemopoiesis
Positive Regulation Of Angiogenesis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Behavioral Response To Pain
Peripheral Nervous System Neuron Development
Definitive Hemopoiesis
Regulation Of Hair Follicle Cell Proliferation
Hematopoietic Stem Cell Proliferation
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Progesterone Secretion
Positive Regulation Of Neuron Projection Development
Negative Regulation Of Neuron Projection Development
Epithelial Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways
Drugs
Diseases
GWAS
Esophageal cancer (
21642993
)
Immune response to smallpox vaccine (IL-6) (
22542470
)
Phospholipid levels (plasma) (
21829377
)
Preeclampsia (
23551011
)
Protein-Protein Interactions
46 interactors:
AES
AR
CBFA2T2
CBFA2T3
CBFB
CCND1
CCND2
CCND3
CDK1
CDK6
CEBPA
CEBPB
COPRS
CTBP2
DNMT1
EFNA2
ELF2
ELF4
EP300
ETS1
FOS
FOXP3
HDAC1
HDAC3
HIPK1
HIPK2
JUN
KAT6A
KAT6B
MYOD1
NCOR1
NCOR2
PAX5
PRMT1
RBM14
SPEN
STUB1
SUV39H1
TAZ
TLE1
TLE2
UBE2L6
UXT
VDR
WWTR1
YAP1
23 interactors:
APP
ATN1
ATXN1L
CBFA2T3
CBFB
FBXL19
GTF2E1
ID3
LBP
MDFI
NCOR1
NCOR2
NEUROG1
NOTCH3
PDP1
PRDM14
RERE
RUNX1
SIN3A
TAL2
TCP1
WDYHV1
ZNF652
Entrez ID
861
9139
HPRD ID
01043
04721
Ensembl ID
ENSG00000159216
ENSG00000078699
Uniprot IDs
Q01196
O43439
PDB IDs
1CMO
1CO1
1E50
1H9D
1LJM
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Transcription, DNA-templated
Gene Expression
RNA Metabolic Process
Regulation Of Transcription, DNA-templated
Negative Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Nucleobase-containing Compound Metabolic Process
Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Cellular Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Organ Development
Developmental Process
System Development
Regulation Of Cellular Process
Cell Differentiation
Multicellular Organismal Development
Anatomical Structure Development
Notch Signaling Pathway
Chromatin Organization
Cellular Metabolic Process
Chromatin Modification
Transforming Growth Factor Beta Receptor Signaling Pathway
Cellular Response To Stimulus
Regulation Of Cell Differentiation
Response To Organic Substance
Transcription, DNA-templated
RNA Biosynthetic Process
RNA Metabolic Process
Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Regulation Of Nitrogen Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Multicellular Organismal Development
Nitrogen Compound Metabolic Process
Biosynthetic Process
Organ Development
Definitive Hemopoiesis
Central Nervous System Development
Developmental Process
System Development
Anatomical Structure Development
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Notch Signaling Pathway
Transcription From RNA Polymerase II Promoter
Negative Regulation Of Gene Expression
Cell Differentiation
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Process
Negative Regulation Of Cell Differentiation
Forebrain Development
DNA-templated Transcription, Initiation
Metabolic Process
Embryo Development
Negative Regulation Of Cellular Metabolic Process
Myeloid Cell Differentiation
Thalamus Development
In Utero Embryonic Development
Nervous System Development
Positive Regulation Of Mitotic Cell Cycle
Tagcloud
?
1q22
aml
correlative
cytogenetic
decitabine
demethylating
elucidate
epigenetics
frequent
haematological
hypermethylation
inactivation
inv
leukaemia
leukaemias
lymphocytic
malignancies
methylated
mostly
myelodysplatic
p13
promoters
re
relapse
runx2
runx3
syndromes
unmethylated
Tagcloud (Difference)
?
1q22
aml
correlative
cytogenetic
decitabine
demethylating
elucidate
epigenetics
frequent
haematological
hypermethylation
inactivation
inv
leukaemia
leukaemias
lymphocytic
malignancies
methylated
mostly
myelodysplatic
p13
promoters
re
relapse
runx2
runx3
syndromes
unmethylated
Tagcloud (Intersection)
?