CBFA2T2 and BAG4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CBFA2T2	BAG4
Description		CBFA2/RUNX1 partner transcriptional co-repressor 2	BAG cochaperone 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Adenyl-nucleotide Exchange Factor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein-folding Chaperone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Epithelial Cell Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Intestinal Epithelial Cell Differentiation	Protein Folding Positive Regulation Of Fibroblast Migration Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Protein Stabilization Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Negative Regulation Of MRNA Modification Ruffle Assembly Negative Regulation Of Protein Targeting To Mitochondrion
Pathways		Specification of primordial germ cells	Regulation of HSF1-mediated heat shock response Signaling by FGFR1 in disease TNF signaling Signaling by plasma membrane FGFR1 fusions
Drugs
Diseases
GWAS		Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Triglyceride levels ( 32203549)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		34 interacting genes: APP ATN1 ATXN1L BAG4 CBFA2T3 CBFB CEP83 FBXL19 GTF2E1 ID3 KIFC3 KRTAP13-2 LBP MAGEA6 MDFI NCOR1 NCOR2 NEUROG1 NOTCH3 NTAQ1 PDP1 PEX14 PHAF1 PRDM6 RERE RUNX1 SIKE1 SIN3A SORBS3 TAL2 TCF4 TCP1 ZC2HC1A ZNF652	141 interacting genes: ABI2 ACOT7 ADAMTSL4 ALG13 ANKHD1 APOBEC1 ARID5A ATAD2 ATOSB ATP23 BAP1 BCAS3 BCL2 BCL6B BEX1 BLZF1 BMS1 C3orf38 CASP2 CASZ1 CBFA2T2 CCL5 CEP55 CIMAP1C CPSF7 DDIT4L DIRAS3 DMRTB1 DZIP3 EFEMP1 EIF4ENIF1 EPSTI1 ERRFI1 FAM222B FARS2 FTH1 FYN GLCE GPANK1 GPS2 GRAP2 GRIP1 HOXA1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 IL13RA2 IL24 IST1 ITIH5 KCTD6 KCTD7 KIF5B KLK5 KLK7 KLK9 KRT31 KRTAP13-1 KRTAP13-4 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP6-3 LASP1 LRATD2 LYPD3 MAGED1 MEI4 MRC2 MTA3 MYOZ1 MYOZ3 MYPOP NAT2 ODF1 P4HA3 PDCD6 PDLIM2 PEF1 PGRMC2 PHF19 PKP2 PLAC8 PPIL6 PRDM14 PRPF6 PRRC2B PSMB5 PYCR3 QKI RAMAC RASL10B RBFOX2 RBM22 RBM42 RBM7 RBPMS RHOBTB2 RNF20 RPL22 RUNX1 SAMD4A SAXO1 SAXO4 SCGB3A1 SF1 SF3B4 SH3RF2 SIAH1 SNRPA SNRPB SNRPC SNRPN SNW1 SS18L1 SUOX TBC1D3B TBC1D3G TBC1D7 TCL1B TEKT5 TFAP2D TFIP11 THRSP TINAGL1 TLE5 TNFRSF1A TNFRSF25 TRAPPC6A TSG101 UNKL USP22 VIM VPS37C ZBTB45 ZBTB5 ZIM2
Entrez ID		9139	9530
HPRD ID		04721	04861
Ensembl ID		ENSG00000078699	ENSG00000156735
Uniprot IDs		O43439	O95429
PDB IDs			1M62 1M7K
Enriched GO Terms of Interacting Partners?		Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Core-binding Factor Complex Regulation Of MiRNA Transcription Negative Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Positive Regulation Of Neuron Differentiation Regulation Of Neuron Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Transcription Regulator Inhibitor Activity Nucleus Histone Deacetylase Complex Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Protein Binding Transcription Repressor Complex Chromatin Binding Protein Dimerization Activity Regulation Of ATP Metabolic Process DNA Binding Negative Regulation Of Androgen Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus Regulation Of Purine Nucleotide Metabolic Process Response To Catecholamine Neuron Differentiation Regulation Of CD8-positive, Alpha-beta T Cell Activation Negative Regulation Of Glycolytic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of ATP Metabolic Process Amyloid-beta Complex	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex Protein Refolding MRNA Metabolic Process MRNA Processing ATP-dependent Protein Folding Chaperone Intermediate Filament RNA Binding RNA Splicing Protein Binding Hair Cycle C3HC4-type RING Finger Domain Binding Transcription Corepressor Activity ATP-dependent Protein Disaggregase Activity Protein Folding Chaperone Cellular Heat Acclimation Nucleus Heat Shock Protein Binding U1 SnRNP U4/U6 X U5 Tri-snRNP Complex Regulation Of RNA Splicing RNA Processing RNA Metabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Catalytic Step 2 Spliceosome Regulation Of MRNA Metabolic Process Identical Protein Binding Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Inclusion Body Assembly Keratin Filament Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Post-translational Protein Modification SnRNP Binding Negative Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding MRNA Binding Response To Temperature Stimulus Nucleic Acid Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome U2-type Prespliceosome Unfolded Protein Binding Positive Regulation Of Antibacterial Peptide Production Epidermal Lamellar Body Macromolecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Calcium-dependent Protein Binding Blood Microparticle
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