CBFA2T2 and FBXL19

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		CBFA2T2	FBXL19
Gene Name		core-binding factor, runt domain, alpha subunit 2; translocated to, 2	F-box and leucine-rich repeat protein 19
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	SCF Ubiquitin Ligase Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding	DNA Binding Zinc Ion Binding
	Biological Process	Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Epithelial Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS			Psoriasis ( 20953189)
Protein-Protein Interactions		23 interactors: APP ATN1 ATXN1L CBFA2T3 CBFB FBXL19 GTF2E1 ID3 LBP MDFI NCOR1 NCOR2 NEUROG1 NOTCH3 PDP1 PRDM14 RERE RUNX1 SIN3A TAL2 TCP1 WDYHV1 ZNF652	3 interactors: CBFA2T2 TRIM27 TRIM29
Entrez ID		9139	54620
HPRD ID		04721	12366
Ensembl ID		ENSG00000078699	ENSG00000099364
Uniprot IDs		O43439	H3BVB1 Q6PCT2
PDB IDs
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Multicellular Organismal Development Nitrogen Compound Metabolic Process Biosynthetic Process Organ Development Definitive Hemopoiesis Central Nervous System Development Developmental Process System Development Anatomical Structure Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Notch Signaling Pathway Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Cell Differentiation Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cell Differentiation Forebrain Development DNA-templated Transcription, Initiation Metabolic Process Embryo Development Negative Regulation Of Cellular Metabolic Process Myeloid Cell Differentiation Thalamus Development In Utero Embryonic Development Nervous System Development Positive Regulation Of Mitotic Cell Cycle	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Interleukin-2 Secretion Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Calcium Ion Import Negative Regulation Of Cellular Metabolic Process Interferon-gamma Secretion Negative Regulation Of Viral Release From Host Cell Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Viral Transcription Regulation Of Viral Release From Host Cell Regulation Of Calcium Ion Import Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Protein Localization Protein K63-linked Ubiquitination Cytokine Secretion Protein Trimerization Negative Regulation Of Cytokine Secretion Negative Regulation Of Adaptive Immune Response Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Calcium Ion Transport Regulation Of Cellular Localization Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Ion Transmembrane Transport Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transmembrane Transport Actin Nucleation Retrograde Transport, Endosome To Golgi Regulation Of Viral Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Viral Process Negative Regulation Of Protein Localization To Nucleus Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Ion Transport Negative Regulation Of Protein Secretion
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