RUNX1 and TAZ

Number of citations of the paper that reports this interaction (PMID 11118213)
99

Data Source:
HPRD (in vitro, in vivo)

		RUNX1	TAZ
Gene Name		runt-related transcription factor 1	tafazzin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Basement Membrane Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle	Nucleus Mitochondrion Mitochondrial Inner Membrane Cytosol Integral Component Of Membrane Intrinsic Component Of Membrane Mitochondrial Membrane
	Molecular Function	Regulatory Region DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Calcium Ion Binding Protein Binding ATP Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Repressing Transcription Factor Binding	1-acylglycerophosphocholine O-acyltransferase Activity
	Biological Process	Skeletal System Development In Utero Embryonic Development Liver Development Myeloid Progenitor Cell Differentiation Transcription, DNA-templated Central Nervous System Development Regulation Of Signal Transduction Hemopoiesis Myeloid Cell Differentiation Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Granulocyte Differentiation Hair Follicle Morphogenesis Embryonic Hemopoiesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Behavioral Response To Pain Peripheral Nervous System Neuron Development Definitive Hemopoiesis Regulation Of Hair Follicle Cell Proliferation Hematopoietic Stem Cell Proliferation Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Progesterone Secretion	Phospholipid Metabolic Process Muscle Contraction Heart Development Skeletal Muscle Tissue Development Hemopoiesis Cardiolipin Biosynthetic Process Mitochondrial Respiratory Chain Complex I Assembly Cardiolipin Acyl-chain Remodeling Cristae Formation Mitochondrial ATP Synthesis Coupled Electron Transport Small Molecule Metabolic Process Glycerophospholipid Biosynthetic Process Cardiac Muscle Tissue Development Cardiac Muscle Contraction
Pathways			Acyl chain remodeling of CL Metabolism of lipids and lipoproteins Mitochondrial protein import Phospholipid metabolism Glycerophospholipid biosynthesis
Drugs
Diseases
GWAS		Esophageal cancer ( 21642993) Immune response to smallpox vaccine (IL-6) ( 22542470) Phospholipid levels (plasma) ( 21829377) Preeclampsia ( 23551011)
Protein-Protein Interactions		46 interactors: AES AR CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CDK1 CDK6 CEBPA CEBPB COPRS CTBP2 DNMT1 EFNA2 ELF2 ELF4 EP300 ETS1 FOS FOXP3 HDAC1 HDAC3 HIPK1 HIPK2 JUN KAT6A KAT6B MYOD1 NCOR1 NCOR2 PAX5 PRMT1 RBM14 SPEN STUB1 SUV39H1 TAZ TLE1 TLE2 UBE2L6 UXT VDR WWTR1 YAP1	9 interactors: BTRC CHGB CSNK1E GSK3B LATS1 LATS2 RUNX1 SLC9A3R2 YWHAE
Entrez ID		861	6901
HPRD ID		01043	02316
Ensembl ID		ENSG00000159216	ENSG00000102125
Uniprot IDs		Q01196	Q16635
PDB IDs		1CMO 1CO1 1E50 1H9D 1LJM
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Developmental Process System Development Regulation Of Cellular Process Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Notch Signaling Pathway Chromatin Organization Cellular Metabolic Process Chromatin Modification Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cell Differentiation Response To Organic Substance	Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Signal Transduction G2/M Transition Of Mitotic Cell Cycle Hippo Signaling Regulation Of Signaling Cell Cycle Process Negative Regulation Of Signal Transduction Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signaling Regulation Of Canonical Wnt Signaling Pathway Cell Cycle Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Circadian Rhythm Cellular Protein Localization Regulation Of Proteasomal Protein Catabolic Process Response To Organic Substance Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Proteolysis Negative Regulation Of Protein Kinase Activity Positive Regulation Of Protein Catabolic Process Regulation Of Cellular Response To Heat Skin Development Negative Regulation Of Kinase Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Epidermis Development Wnt Signaling Pathway Negative Regulation Of Cellular Protein Metabolic Process Organ Development Tissue Development Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Rhythmic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Protein Localization Positive Regulation Of Mitochondrion Organization Cellular Response To Heat Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process
Tagcloud ?		1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx2 runx3 syndromes unmethylated	ages avoid bacteriological careful chest chromatographically clarify clearance comprised creatinine deliberate elderly evaluations impairment influencing japanese late nephrotoxicity pay pharmacokinetic pharmacokinetics pilot pipc piperacillin planning pneumonia rays serious tazobactam
Tagcloud (Difference) ?		1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx2 runx3 syndromes unmethylated	ages avoid bacteriological careful chest chromatographically clarify clearance comprised creatinine deliberate elderly evaluations impairment influencing japanese late nephrotoxicity pay pharmacokinetic pharmacokinetics pilot pipc piperacillin planning pneumonia rays serious tazobactam
Tagcloud (Intersection) ?