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RUNX1
Description
RUNX family transcription factor 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Core-binding Factor Complex
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
Transcription Coactivator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Calcium Ion Binding
Protein Binding
ATP Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
DNA-binding Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Ossification
Chondrocyte Differentiation
Myeloid Leukocyte Differentiation
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Regulation Of Plasminogen Activation
Hemopoiesis
Myeloid Cell Differentiation
Neuron Differentiation
Negative Regulation Of Granulocyte Differentiation
Positive Regulation Of Granulocyte Differentiation
Positive Regulation Of Interleukin-2 Production
Positive Regulation Of Collagen Biosynthetic Process
Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation
Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation
Regulation Of Cell Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Peripheral Nervous System Neuron Development
Positive Regulation Of Developmental Process
Positive Regulation Of Multicellular Organismal Process
Regulation Of Cardiac Muscle Cell Proliferation
Cardiac Muscle Tissue Regeneration
Hematopoietic Stem Cell Proliferation
Positive Regulation Of Extracellular Matrix Organization
Regulation Of Connective Tissue Replacement
Regulation Of Multicellular Organismal Development
Pathways
Pre-NOTCH Transcription and Translation
SLC-mediated transport of organic cations
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
RUNX1 regulates estrogen receptor mediated transcription
Regulation of RUNX1 Expression and Activity
Regulation of RUNX1 Expression and Activity
RUNX1 regulates expression of components of tight junctions
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
RUNX1 regulates transcription of genes involved in BCR signaling
RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
RUNX1 regulates transcription of genes involved in interleukin signaling
RUNX1 regulates transcription of genes involved in WNT signaling
RUNX2 regulates genes involved in differentiation of myeloid cells
RUNX3 regulates p14-ARF
Estrogen-dependent gene expression
Transcriptional regulation of granulopoiesis
SARS-CoV-1 activates/modulates innate immune responses
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs
Diseases
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
Acute myeloid leukemia (AML)
Chronic myeloid leukemia (CML)
Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS
3-month functional outcome in ischaemic stroke (modified Rankin score) (
30796134
)
Age-related cognitive decline (language) (slope of z-scores) (
30954325
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Appendicular lean mass (
33097823
)
Asthma (
34103634
32296059
31959851
31619474
31361310
30929738
)
Asthma (adult onset) (
31036433
30929738
)
Basophil count (
32888494
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
32888494
27863252
)
Brain-derived neurotrophic factor levels (
33345186
)
Breast cancer (
31757997
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Core binding factor acute myeloid leukemia (
27903959
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
27863252
32888494
)
Esophageal cancer (
21642993
)
Esophageal squamous cell carcinoma (
25129146
)
Femoral neck length (
30888730
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
Gut microbiota alpha diversity (Chao1 index) (
33208821
)
HDL cholesterol (
30275531
)
Heel bone mineral density (
30598549
)
Height (
28552196
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Hemoglobin levels (
32327693
)
Hip index (
34021172
)
IgG N-glycosylation phenotypes (multivariate analysis) (
32128391
)
Immune response to smallpox vaccine (IL-6) (
22542470
)
Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) (
23603761
)
Male-pattern baldness (
28196072
29146897
27182965
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean platelet volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Medication use (adrenergics, inhalants) (
31015401
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Myeloproliferative neoplasms (
33057200
)
Neutrophil percentage of granulocytes (
27863252
)
Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) (
21829377
)
Platelet count (
27863252
32888494
)
Plateletcrit (
32888494
27863252
)
Preeclampsia (
23551011
)
Psoriasis (
25903422
)
Red blood cell count (
32888494
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Rheumatoid arthritis (
30423114
23143596
24390342
)
Rheumatoid arthritis (ACPA-positive) (
23143596
24532676
)
Stroke (
32693751
)
Sum eosinophil basophil counts (
27863252
)
White blood cell count (basophil) (
27863252
)
Novel Interacting Genes
8 novel interacting genes:
COL6A1
COL6A2
CRYAA
CSTB
PHTF1
PTPN12
PTTG1IP
TNR
Interacting Genes
119 interacting genes:
ABCA2
ABHD14A
AGTPBP1
ALKBH6
APEH
AR
ARGLU1
ARID5B
ATP13A1
B4GAT1
BAG3
BAG4
BTBD2
CBFA2T2
CBFA2T3
CBFB
CCND1
CCND2
CCND3
CCNK
CDK1
CDK2
CDK6
CEBPA
CEBPB
CERCAM
CLIP4
CNOT3
CNRIP1
COPA
COPRS
DAZAP2
DNMT1
DTX2
DZIP3
EEF2
ELF1
ELF2
ELF4
EP300
FAM222B
FBXO17
FOS
FOXP3
FOXRED1
GCC1
GDI1
GSK3A
GTPBP6
HGS
HIPK1
HIPK2
HLA-DRB1
IDS
IKZF1
IKZF3
JUN
KAT6A
KAT6B
MAGI3
MAPK1
ME3
METTL26
MPPED2
MSTO1
MYOD1
NCOR1
NCOR2
NDST1
NFKBID
OLFM1
OLIG3
PAX5
PICK1
PKD1
PLEKHB1
PLEKHB2
PPP3CB
PRDM4
PRMT1
PRRC2A
PSMB4
RBFOX3
RBM14
RNF38
RNF44
SEC31B
SNRNP70
SNRPC
SPEN
SPI1
STUB1
SULT4A1
SUV39H1
TAFAZZIN
TCERG1
TEAD2
TEAD4
TEKT5
TLE1
TLE2
TLE5
TMEM222
TOLLIP
TRIM5
TUBA1B
UBE2L6
UHRF2
UROD
USP10
UXT
VDR
VPS37C
VPS39
WBP2
WWP1
WWTR1
YAP1
ZMYM4
Entrez ID
861
HPRD ID
01043
Ensembl ID
ENSG00000159216
Uniprot IDs
Q01196
PDB IDs
1CMO
1CO1
1E50
1H9D
1LJM
Enriched GO Terms of Interacting Partners
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Nucleoplasm
Regulation Of DNA-templated Transcription
Regulation Of RNA Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Biosynthetic Process
Transcription Corepressor Activity
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Primary Metabolic Process
Nucleus
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Metabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Macromolecule Metabolic Process
Cell Differentiation
DNA-templated Transcription
Regulation Of Macromolecule Biosynthetic Process
Transcription Regulator Complex
Regulation Of Gene Expression
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Transcription Coactivator Activity
Cyclin-dependent Protein Kinase Holoenzyme Complex
Cellular Developmental Process
Regulation Of Cell Differentiation
Chromatin Binding
Developmental Process
Leukocyte Differentiation
Mononuclear Cell Differentiation
Chromatin
Regulation Of Developmental Process
Regulation Of Multicellular Organismal Development
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Chromatin Remodeling
Cyclin-dependent Protein Serine/threonine Kinase Activity
Transcription By RNA Polymerase II
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