RUNX1 and KAT6A

Number of citations of the paper that reports this interaction (PMID 16702405)
28

Data Source:
HPRD (in vivo)

		RUNX1	KAT6A
Gene Name		runt-related transcription factor 1	K(lysine) acetyltransferase 6A
Image
Gene Ontology Annotations	Cellular Component	Basement Membrane Nucleus Nucleoplasm Cytoplasm Intracellular Membrane-bounded Organelle	Nucleosome Nucleus Nucleoplasm Nucleolus Golgi Apparatus PML Body MOZ/MORF Histone Acetyltransferase Complex
	Molecular Function	Regulatory Region DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Calcium Ion Binding Protein Binding ATP Binding Transcription Factor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Repressing Transcription Factor Binding	DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity
	Biological Process	Skeletal System Development In Utero Embryonic Development Liver Development Myeloid Progenitor Cell Differentiation Transcription, DNA-templated Central Nervous System Development Regulation Of Signal Transduction Hemopoiesis Myeloid Cell Differentiation Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Granulocyte Differentiation Hair Follicle Morphogenesis Embryonic Hemopoiesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Behavioral Response To Pain Peripheral Nervous System Neuron Development Definitive Hemopoiesis Regulation Of Hair Follicle Cell Proliferation Hematopoietic Stem Cell Proliferation Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Progesterone Secretion	Heart Morphogenesis DNA Packaging Chromatin Organization Nucleosome Assembly Transcription, DNA-templated Protein Acetylation Histone Acetylation Myeloid Cell Differentiation Somatic Stem Cell Maintenance Embryonic Hemopoiesis Aorta Morphogenesis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H3 Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Face Morphogenesis Cellular Senescence
Pathways			Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS		Esophageal cancer ( 21642993) Immune response to smallpox vaccine (IL-6) ( 22542470) Phospholipid levels (plasma) ( 21829377) Preeclampsia ( 23551011)
Protein-Protein Interactions		46 interactors: AES AR CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CDK1 CDK6 CEBPA CEBPB COPRS CTBP2 DNMT1 EFNA2 ELF2 ELF4 EP300 ETS1 FOS FOXP3 HDAC1 HDAC3 HIPK1 HIPK2 JUN KAT6A KAT6B MYOD1 NCOR1 NCOR2 PAX5 PRMT1 RBM14 SPEN STUB1 SUV39H1 TAZ TLE1 TLE2 UBE2L6 UXT VDR WWTR1 YAP1	18 interactors: AKT1 ATN1 ATXN1 CREBBP H3F3C HIST1H3A HIST1H4A HIST1H4I HIST2H3C HIST3H3 HIST4H4 MAFK PML RERE RUNX1 SPI1 TP53 UBE2U
Entrez ID		861	7994
HPRD ID		01043	03244
Ensembl ID		ENSG00000159216	ENSG00000083168
Uniprot IDs		Q01196	A5PKX7 Q92794
PDB IDs		1CMO 1CO1 1E50 1H9D 1LJM	1M36 2LN0 2OZU 2RC4 3V43
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Organ Development Developmental Process System Development Regulation Of Cellular Process Cell Differentiation Multicellular Organismal Development Anatomical Structure Development Notch Signaling Pathway Chromatin Organization Cellular Metabolic Process Chromatin Modification Transforming Growth Factor Beta Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of Cell Differentiation Response To Organic Substance	DNA Methylation On Cytosine Chromatin Silencing At RDNA Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Chromatin Silencing Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process DNA Replication-dependent Nucleosome Assembly Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Chromosome Organization Chromatin Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process DNA Methylation Negative Regulation Of Cellular Metabolic Process Histone H4-K20 Demethylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process DNA Modification Regulation Of RNA Metabolic Process Regulation Of Gene Expression, Epigenetic Negative Regulation Of Megakaryocyte Differentiation Gene Silencing Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Chromatin Assembly Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Chromatin Assembly Or Disassembly Chromatin Modification Regulation Of Myeloid Cell Differentiation DNA Packaging Organelle Organization Histone Modification Telomere Maintenance DNA Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Cell Differentiation Regulation Of Cell Differentiation Nucleocytoplasmic Transport CENP-A Containing Nucleosome Assembly Nuclear Transport DNA Conformation Change Protein Import Into Nucleus
Tagcloud ?		1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx2 runx3 syndromes unmethylated	acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes localizes lymphoma maintain maintaining maintains malignancy meis1 menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Difference) ?		1q22 aml correlative cytogenetic decitabine demethylating elucidate epigenetics frequent haematological hypermethylation inactivation inv leukaemia leukaemias lymphocytic malignancies methylated mostly myelodysplatic p13 promoters re relapse runx2 runx3 syndromes unmethylated	acetyltransferase aggressive characteristically emu fusing haploinsufficient hence homeobox hox includes localizes lymphoma maintain maintaining maintains malignancy meis1 menin mll1 moz myst3 ncoa3 overlap progenitor progenitors proliferative tale tif2 translocations
Tagcloud (Intersection) ?