RUNX1 and CCND3

Number of citations of the paper that reports this interaction (PubMedID 16287839)
58

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		RUNX1	CCND3
Description		RUNX family transcription factor 1	cyclin D3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Core-binding Factor Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Calcium Ion Binding Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ossification Chondrocyte Differentiation Myeloid Leukocyte Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of Plasminogen Activation Hemopoiesis Myeloid Cell Differentiation Neuron Differentiation Negative Regulation Of Granulocyte Differentiation Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Interleukin-2 Production Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Peripheral Nervous System Neuron Development Positive Regulation Of Developmental Process Positive Regulation Of Multicellular Organismal Process Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Tissue Regeneration Hematopoietic Stem Cell Proliferation Positive Regulation Of Extracellular Matrix Organization Regulation Of Connective Tissue Replacement Regulation Of Multicellular Organismal Development	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction T Cell Proliferation Regulation Of Cell Population Proliferation Cell Division Regulation Of Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Pre-NOTCH Transcription and Translation SLC-mediated transport of organic cations RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates estrogen receptor mediated transcription Regulation of RUNX1 Expression and Activity Regulation of RUNX1 Expression and Activity RUNX1 regulates expression of components of tight junctions RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 regulates transcription of genes involved in WNT signaling RUNX2 regulates genes involved in differentiation of myeloid cells RUNX3 regulates p14-ARF Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis SARS-CoV-1 activates/modulates innate immune responses Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	Transcriptional regulation of white adipocyte differentiation MAPK6/MAPK4 signaling Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Acute myeloid leukemia (AML) Chronic myeloid leukemia (CML) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Allergic disease (asthma, hay fever or eczema) ( 29083406) Appendicular lean mass ( 33097823) Asthma ( 34103634 32296059 31959851 31619474 31361310 30929738) Asthma (adult onset) ( 31036433 30929738) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Brain-derived neurotrophic factor levels ( 33345186) Breast cancer ( 31757997) Celiac disease and Rheumatoid arthritis ( 26546613) Core binding factor acute myeloid leukemia ( 27903959) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Esophageal cancer ( 21642993) Esophageal squamous cell carcinoma ( 25129146) Femoral neck length ( 30888730) Femur bone mineral density x serum urate levels interaction ( 34046847) Gut microbiota alpha diversity (Chao1 index) ( 33208821) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Hip index ( 34021172) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391) Immune response to smallpox vaccine (IL-6) ( 22542470) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Male-pattern baldness ( 28196072 29146897 27182965) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Myeloproliferative neoplasms ( 33057200) Neutrophil percentage of granulocytes ( 27863252) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Platelet count ( 27863252 32888494) Plateletcrit ( 32888494 27863252) Preeclampsia ( 23551011) Psoriasis ( 25903422) Red blood cell count ( 32888494) Red cell distribution width ( 32888494) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Stroke ( 32693751) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 27863252)	Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Cardiometabolic and hematological traits ( 27668658) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 28334899 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematological parameters ( 19820697) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 29403010 32888494 28453575 28017375 19862010 20139978 27863252) Mean corpuscular hemoglobin concentration ( 28017375 32888494) Mean corpuscular volume ( 20139978 32888494 23263863 29403010 27863252 28453575 19862010 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 21507922) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 20139978 29403010 27863252 32888494 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		119 interacting genes: ABCA2 ABHD14A AGTPBP1 ALKBH6 APEH AR ARGLU1 ARID5B ATP13A1 B4GAT1 BAG3 BAG4 BTBD2 CBFA2T2 CBFA2T3 CBFB CCND1 CCND2 CCND3 CCNK CDK1 CDK2 CDK6 CEBPA CEBPB CERCAM CLIP4 CNOT3 CNRIP1 COPA COPRS DAZAP2 DNMT1 DTX2 DZIP3 EEF2 ELF1 ELF2 ELF4 EP300 FAM222B FBXO17 FOS FOXP3 FOXRED1 GCC1 GDI1 GSK3A GTPBP6 HGS HIPK1 HIPK2 HLA-DRB1 IDS IKZF1 IKZF3 JUN KAT6A KAT6B MAGI3 MAPK1 ME3 METTL26 MPPED2 MSTO1 MYOD1 NCOR1 NCOR2 NDST1 NFKBID OLFM1 OLIG3 PAX5 PICK1 PKD1 PLEKHB1 PLEKHB2 PPP3CB PRDM4 PRMT1 PRRC2A PSMB4 RBFOX3 RBM14 RNF38 RNF44 SEC31B SNRNP70 SNRPC SPEN SPI1 STUB1 SULT4A1 SUV39H1 TAFAZZIN TCERG1 TEAD2 TEAD4 TEKT5 TLE1 TLE2 TLE5 TMEM222 TOLLIP TRIM5 TUBA1B UBE2L6 UHRF2 UROD USP10 UXT VDR VPS37C VPS39 WBP2 WWP1 WWTR1 YAP1 ZMYM4	57 interacting genes: AKAP8 APP AREG ATF5 ATP5F1C C14orf119 CASP2 CCDC13 CDK11B CDK14 CDK16 CDK18 CDK3 CDK4 CDK5 CDK6 CDKN1A CDKN1B CDKN2D CRABP2 DMRTB1 DMTF1 DTNBP1 EFEMP2 EIF3K ETV1 FAS FHL3 GC HGS KIFC3 LSM3 MAF1 MAPK4 MAPK6 MCM10 MNS1 MYB NCOA2 NME1 NPDC1 PCNA POLD1 POLR3GL PSMC1 QKI RARA RB1 RBL2 RUNX1 SH3GLB2 SIL1 TEX11 TFIP11 TSG101 USP10 VDR
Entrez ID		861	896
HPRD ID		01043	00452
Ensembl ID		ENSG00000159216	ENSG00000112576
Uniprot IDs		Q01196	B3KP19 P30281 Q5T8J1
PDB IDs		1CMO 1CO1 1E50 1H9D 1LJM	3G33 7SJ3
Enriched GO Terms of Interacting Partners?		Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Transcription Corepressor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Cell Differentiation DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Transcription Coactivator Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Cellular Developmental Process Regulation Of Cell Differentiation Chromatin Binding Developmental Process Leukocyte Differentiation Mononuclear Cell Differentiation Chromatin Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Chromatin Remodeling Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription By RNA Polymerase II	Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin Binding Nucleus Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Cytosol Protein Serine Kinase Activity Nucleoplasm Negative Regulation Of Cell Population Proliferation Protein Serine/threonine Kinase Activity Kinase Activity Protein Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Acetylcholine Receptor Activator Activity Negative Regulation Of Developmental Process PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity DNA Synthesis Involved In DNA Repair Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Negative Regulation Of Myeloid Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Cycle Cytoplasm Nucleobase-containing Compound Biosynthetic Process Regulation Of Growth Negative Regulation Of Myeloid Leukocyte Differentiation Cyclin D2-CDK4 Complex Regulation Of Metabolic Process Positive Regulation Of Fibroblast Proliferation Negative Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle DNA Damage Response Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Growth Negative Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Negative Regulation Of DNA-templated Transcription Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Lipid Kinase Activity Positive Regulation Of Collagen Fibril Organization Regulation Of Programmed Cell Death
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