CCND3 and CRABP2

Number of citations of the paper that reports this interaction (PubMedID 12482873)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CCND3	CRABP2
Description		cyclin D3	cellular retinoic acid binding protein 2
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Extracellular Exosome
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Retinoic Acid Binding Retinoid Binding Fatty Acid Binding Protein Binding Lipid Binding Retinal Binding Retinol Binding Cyclin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction T Cell Proliferation Regulation Of Cell Population Proliferation Cell Division Regulation Of Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of DNA-templated Transcription Signal Transduction Epidermis Development Fatty Acid Transport Embryonic Forelimb Morphogenesis Retinoic Acid Metabolic Process Positive Regulation Of Collateral Sprouting
Pathways		Transcriptional regulation of white adipocyte differentiation MAPK6/MAPK4 signaling Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity	Signaling by Retinoic Acid
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Cardiometabolic and hematological traits ( 27668658) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 28334899 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematological parameters ( 19820697) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 29403010 32888494 28453575 28017375 19862010 20139978 27863252) Mean corpuscular hemoglobin concentration ( 28017375 32888494) Mean corpuscular volume ( 20139978 32888494 23263863 29403010 27863252 28453575 19862010 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 21507922) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 20139978 29403010 27863252 32888494 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)
Interacting Genes		57 interacting genes: AKAP8 APP AREG ATF5 ATP5F1C C14orf119 CASP2 CCDC13 CDK11B CDK14 CDK16 CDK18 CDK3 CDK4 CDK5 CDK6 CDKN1A CDKN1B CDKN2D CRABP2 DMRTB1 DMTF1 DTNBP1 EFEMP2 EIF3K ETV1 FAS FHL3 GC HGS KIFC3 LSM3 MAF1 MAPK4 MAPK6 MCM10 MNS1 MYB NCOA2 NME1 NPDC1 PCNA POLD1 POLR3GL PSMC1 QKI RARA RB1 RBL2 RUNX1 SH3GLB2 SIL1 TEX11 TFIP11 TSG101 USP10 VDR	4 interacting genes: ACTN2 CCND3 FLAD1 KASH5
Entrez ID		896	1382
HPRD ID		00452	08353
Ensembl ID		ENSG00000112576	ENSG00000143320
Uniprot IDs		B3KP19 P30281 Q5T8J1	P29373
PDB IDs		3G33 7SJ3	1BLR 1BM5 1CBQ 1CBS 1XCA 2CBS 2FR3 2FRS 2FS6 2FS7 2G78 2G79 2G7B 3CBS 3CR6 3CWK 3D95 3D96 3D97 3F8A 3F9D 3FA6 3FA7 3FA8 3FA9 3FEK 3FEL 3FEN 3FEP 3I17 4I9R 4I9S 4M6S 4M7M 4QGV 4QGW 4QGX 4YBP 4YBU 4YCE 4YCH 4YDA 4YDB 4YFP 4YFQ 4YFR 4YGG 4YGH 4YGZ 4YH0 4YKM 4YKO 5HZQ 5OGB 6HKR 6MOP 6MOQ 6MOR 6MOV 6MOW 6MOX 6MPK 6MQI 6MQJ 6MQW 6MQX 6MQY 6MQZ 6MR0 6NNX 6NNY 6NOE 6Z2U 6Z2Z 6ZSW 6ZSX 7AA0 7AA1 7OXW 7OXX 7RY5
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin Binding Nucleus Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Cytosol Protein Serine Kinase Activity Nucleoplasm Negative Regulation Of Cell Population Proliferation Protein Serine/threonine Kinase Activity Kinase Activity Protein Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Acetylcholine Receptor Activator Activity Negative Regulation Of Developmental Process PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity DNA Synthesis Involved In DNA Repair Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Negative Regulation Of Myeloid Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Cycle Cytoplasm Nucleobase-containing Compound Biosynthetic Process Regulation Of Growth Negative Regulation Of Myeloid Leukocyte Differentiation Cyclin D2-CDK4 Complex Regulation Of Metabolic Process Positive Regulation Of Fibroblast Proliferation Negative Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle DNA Damage Response Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Growth Negative Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Negative Regulation Of DNA-templated Transcription Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Lipid Kinase Activity Positive Regulation Of Collagen Fibril Organization Regulation Of Programmed Cell Death	Titin Z Domain Binding Actin Filament Uncapping Z Disc Cyclin D3-CDK6 Complex Cyclin D3-CDK4 Complex FMN Adenylyltransferase Activity Flavin Adenine Dinucleotide Biosynthetic Process FAD Biosynthetic Process FAD Diphosphatase Activity Meiotic Spindle Pole Phospholipase C-activating Angiotensin-activated Signaling Pathway Microspike Assembly Small Conductance Calcium-activated Potassium Channel Activity Riboflavin Metabolic Process FATZ Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Channel Activator Activity LIM Domain Binding Positive Regulation Of Endocytic Recycling Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization Postsynaptic Actin Cytoskeleton Meiotic Nuclear Membrane Microtubule Tethering Complex Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Actin Filament Depolymerization Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Calcium-activated Potassium Channel Activity Titin Binding Lateral Element Postsynaptic Actin Cytoskeleton Organization Pseudopodium Postsynaptic Density, Intracellular Component Positive Regulation Of Protein Depolymerization Postsynaptic Cytoskeleton Organization Angiotensin-activated Signaling Pathway Regulation Of Endocytic Recycling Dynein Complex Binding
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