CCND3 and SH3GLB2

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		CCND3	SH3GLB2
Description		cyclin D3	SH3 domain containing GRB2 like, endophilin B2
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex	Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Protein Binding Identical Protein Binding Cadherin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction T Cell Proliferation Regulation Of Cell Population Proliferation Cell Division Regulation Of Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Membrane Organization
Pathways		Transcriptional regulation of white adipocyte differentiation MAPK6/MAPK4 signaling Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Cardiometabolic and hematological traits ( 27668658) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 28334899 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematological parameters ( 19820697) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 29403010 32888494 28453575 28017375 19862010 20139978 27863252) Mean corpuscular hemoglobin concentration ( 28017375 32888494) Mean corpuscular volume ( 20139978 32888494 23263863 29403010 27863252 28453575 19862010 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 21507922) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 20139978 29403010 27863252 32888494 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)	Blood metabolite levels ( 26401656) Serum metabolite concentrations in chronic kidney disease ( 33838163)
Interacting Genes		57 interacting genes: AKAP8 APP AREG ATF5 ATP5F1C C14orf119 CASP2 CCDC13 CDK11B CDK14 CDK16 CDK18 CDK3 CDK4 CDK5 CDK6 CDKN1A CDKN1B CDKN2D CRABP2 DMRTB1 DMTF1 DTNBP1 EFEMP2 EIF3K ETV1 FAS FHL3 GC HGS KIFC3 LSM3 MAF1 MAPK4 MAPK6 MCM10 MNS1 MYB NCOA2 NME1 NPDC1 PCNA POLD1 POLR3GL PSMC1 QKI RARA RB1 RBL2 RUNX1 SH3GLB2 SIL1 TEX11 TFIP11 TSG101 USP10 VDR	39 interacting genes: CCDC158 CCND3 CDKN2D CNOT7 EFHC1 EXOSC1 EXOSC5 FHL3 FXR1 GAA GADD45G GIT2 GOLGA2 KDM1A KRTAP10-1 KRTAP10-8 KRTAP4-5 KRTAP5-11 KRTAP9-3 LGALS14 LNX2 LSM3 MAGEA1 MORF4L1 NMI NTAQ1 NXF1 OGT PICK1 RSPH1 SH3GLB1 SH3KBP1 SREK1 STX4 TBC1D7 TEX11 TRAF1 TSG101 YES1
Entrez ID		896	56904
HPRD ID		00452	15334
Ensembl ID		ENSG00000112576	ENSG00000148341
Uniprot IDs		B3KP19 P30281 Q5T8J1	B7ZC38 B7ZC39 Q9NR46
PDB IDs		3G33 7SJ3
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin Binding Nucleus Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Cytosol Protein Serine Kinase Activity Nucleoplasm Negative Regulation Of Cell Population Proliferation Protein Serine/threonine Kinase Activity Kinase Activity Protein Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Acetylcholine Receptor Activator Activity Negative Regulation Of Developmental Process PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity DNA Synthesis Involved In DNA Repair Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Negative Regulation Of Myeloid Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Cycle Cytoplasm Nucleobase-containing Compound Biosynthetic Process Regulation Of Growth Negative Regulation Of Myeloid Leukocyte Differentiation Cyclin D2-CDK4 Complex Regulation Of Metabolic Process Positive Regulation Of Fibroblast Proliferation Negative Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle DNA Damage Response Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Growth Negative Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Negative Regulation Of DNA-templated Transcription Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Lipid Kinase Activity Positive Regulation Of Collagen Fibril Organization Regulation Of Programmed Cell Death	RNA Exonuclease Activity Cytosol Intermediate Filament Autophagic Cell Death Keratin Filament Cell Death Programmed Cell Death Nucleolar Exosome (RNase Complex)
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