CCND3 and QKI

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		CCND3	QKI
Description		cyclin D3	QKI, KH domain containing RNA binding
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Cytosol Cyclin D3-CDK4 Complex Cyclin D3-CDK6 Complex	Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Synapse
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Protein Serine/threonine Kinase Activator Activity Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Nucleic Acid Binding DNA Binding Transcription Coactivator Activity RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding SH3 Domain Binding MiRNA Binding Internal N(7)-methylguanine-containing RNA Reader Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Signal Transduction T Cell Proliferation Regulation Of Cell Population Proliferation Cell Division Regulation Of Cell Cycle Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Vasculogenesis MRNA Processing Regulation Of Translation Spermatid Development Intracellular MRNA Localization Axon Ensheathment RNA Splicing Positive Regulation Of Gene Expression Regulation Of Epithelial To Mesenchymal Transition Microglia Differentiation Negative Regulation Of Angiogenesis Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Myelination Negative Regulation Of Type I Interferon Production Stress Granule Assembly Vascular Associated Smooth Muscle Cell Differentiation Myelination Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Cholesterol Biosynthetic Process Regulation Of Macrophage Differentiation Negative Regulation Of Macrophage Differentiation Positive Regulation Of DNA-templated Transcription Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization Regulation Of Astrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation MRNA Transport Regulation Of Cell Development Negative Regulation Of Cold-induced Thermogenesis Spliceosome-depend Formation Of Circular RNA Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Myofibroblast Contraction Regulation Of Multicellular Organismal Development Negative Regulation Of MiRNA Catabolic Process
Pathways		Transcriptional regulation of white adipocyte differentiation MAPK6/MAPK4 signaling Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) Drug-mediated inhibition of CDK4/CDK6 activity	Signaling by BRAF and RAF1 fusions
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Cardiometabolic and hematological traits ( 27668658) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 28334899 32203549) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematological parameters ( 19820697) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 29403010 32888494 28453575 28017375 19862010 20139978 27863252) Mean corpuscular hemoglobin concentration ( 28017375 32888494) Mean corpuscular volume ( 20139978 32888494 23263863 29403010 27863252 28453575 19862010 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 21507922) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red blood cell count ( 20139978 29403010 27863252 32888494 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252 32888494) White blood cell count ( 32888494)	Cataracts ( 34127677) Diastolic blood pressure ( 27841878) Diisocyanate-induced asthma ( 25918132) Fasting insulin ( 34059833) Height ( 31562340) Hemoglobin ( 32888494) Incident myocardial infarction ( 26950853) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444) Platelet distribution width ( 32888494) Red blood cell count ( 29403010) Refractive error ( 32231278) Response to TNF antagonist treatment ( 18615156) Seasonality and depression ( 30217971) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969 30718926)
Interacting Genes		57 interacting genes: AKAP8 APP AREG ATF5 ATP5F1C C14orf119 CASP2 CCDC13 CDK11B CDK14 CDK16 CDK18 CDK3 CDK4 CDK5 CDK6 CDKN1A CDKN1B CDKN2D CRABP2 DMRTB1 DMTF1 DTNBP1 EFEMP2 EIF3K ETV1 FAS FHL3 GC HGS KIFC3 LSM3 MAF1 MAPK4 MAPK6 MCM10 MNS1 MYB NCOA2 NME1 NPDC1 PCNA POLD1 POLR3GL PSMC1 QKI RARA RB1 RBL2 RUNX1 SH3GLB2 SIL1 TEX11 TFIP11 TSG101 USP10 VDR	90 interacting genes: ALG13 ANKHD1 APP ATXN1 BAG4 BCAS2 CALD1 CARM1 CCDC59 CCND3 CDKN2D CEBPA CPSF7 DAZ1 DAZ4 DEPP1 DMRTB1 EIF4ENIF1 FBXO7 FHL3 FUBP3 HCLS1 HLCS HNRNPH2 HNRNPK HNRNPLL IL7R KIF21B LSM3 LSM5 MBNL1 MBNL2 MIR141 MIR19B2 MIR200A MIR34B MIR34C MIR7-1 MRPL44 MSI2 NABP1 NEIL3 NIP7 NXF1 PCBP1 PCBP2 PCBP3 PCBP4 PCGF5 PIAS1 PRKAB2 PRMT1 PRPF39 PRPF6 PRRC2B PSMF1 PTBP1 PTBP2 RALY RBFOX1 RBFOX2 RBM11 RBM14 RBM23 RBM42 RBM7 RBPMS RNF138 RPL9 SECISBP2 SERF2 SLAIN1 SNRPA SNRPC TEX11 THAP1 TIAL1 TNRC6A TRNAU1AP TSG101 TXNL4A U2AF2 UNKL USH1C UTP6 WDR77 YTHDF1 YTHDF3 ZC3H10 ZMAT5
Entrez ID		896	9444
HPRD ID		00452	06691
Ensembl ID		ENSG00000112576	ENSG00000112531
Uniprot IDs		B3KP19 P30281 Q5T8J1	Q8WY44 Q96PU8
PDB IDs		3G33 7SJ3	4JVH
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Kinase Holoenzyme Complex Cyclin Binding Nucleus Regulation Of Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Cytosol Protein Serine Kinase Activity Nucleoplasm Negative Regulation Of Cell Population Proliferation Protein Serine/threonine Kinase Activity Kinase Activity Protein Kinase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Acetylcholine Receptor Activator Activity Negative Regulation Of Developmental Process PCNA-p21 Complex Negative Regulation Of Cardiac Muscle Tissue Regeneration Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity DNA Synthesis Involved In DNA Repair Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Population Proliferation Negative Regulation Of Myeloid Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Cycle Cytoplasm Nucleobase-containing Compound Biosynthetic Process Regulation Of Growth Negative Regulation Of Myeloid Leukocyte Differentiation Cyclin D2-CDK4 Complex Regulation Of Metabolic Process Positive Regulation Of Fibroblast Proliferation Negative Regulation Of RNA Metabolic Process Regulation Of Mitotic Cell Cycle DNA Damage Response Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Cell Growth Negative Regulation Of RNA Biosynthetic Process Regulation Of Developmental Process Negative Regulation Of DNA-templated Transcription Regulation Of Myeloid Leukocyte Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Lipid Kinase Activity Positive Regulation Of Collagen Fibril Organization Regulation Of Programmed Cell Death	RNA Binding Nucleic Acid Binding Regulation Of RNA Splicing MRNA Binding RNA Splicing Regulation Of MRNA Metabolic Process MRNA Processing MRNA Metabolic Process Nucleic Acid Metabolic Process RNA Processing RNA Metabolic Process Nucleus Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Ribonucleoprotein Complex Negative Regulation Of MRNA Metabolic Process Post-transcriptional Regulation Of Gene Expression MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Splicing, Via Transesterification Reactions Nucleoplasm Negative Regulation Of RNA Splicing Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process MRNA 3'-UTR Binding Cytoplasmic Stress Granule Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process U4/U6 X U5 Tri-snRNP Complex Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Negative Regulation Of Biosynthetic Process Negative Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Commitment Complex Regulation Of Translation Viral RNA Genome Replication Regulation Of MRNA Stability Negative Regulation Of RNA Metabolic Process
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