TSPYL2 and KDM6B

Number of citations of the paper that reports this interaction (PubMedID 30051352)
56

Data Source:
BioGRID (pull down)

		TSPYL2	KDM6B
Description		TSPY like 2	lysine demethylase 6B
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Nucleoplasm MLL3/4 Complex
	Molecular Function	RDNA Binding Chromatin Binding Protein Binding Histone Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Beta-catenin Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Sequence-specific DNA Binding Metal Ion Binding Dioxygenase Activity Histone H3K27me2/H3K27me3 Demethylase Activity
	Biological Process	Chromatin Organization Nucleosome Assembly Negative Regulation Of DNA Replication Regulation Of Signal Transduction Negative Regulation Of Cell Growth Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity	Inflammatory Response To Antigenic Stimulus Chromatin Organization Chromatin Remodeling Inflammatory Response Heart Development Regulation Of Gene Expression Response To Activity Hippocampus Development Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesodermal Cell Differentiation Cardiac Muscle Cell Differentiation Response To Fungicide Cellular Response To Hydrogen Peroxide Positive Regulation Of Cold-induced Thermogenesis
Pathways		XBP1(S) activates chaperone genes	Oxidative Stress Induced Senescence HDMs demethylate histones Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases
GWAS			Alcohol consumption (drinks per week) ( 30643258) Brain morphology (MOSTest) ( 32665545) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 29782485 25429064) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		51 interacting genes: ABT1 AEBP2 APTX CASK CCNB1 CDK1 CDK2 CDK4 CEP19 COIL CREBBP CSNK2A1 DYRK1A EEF1A1 EZH2 GFI1B H2BC15 H3C1 HMGXB4 INO80B KDM6A KDM6B KMT5B LMO2 LNX1 MCRS1 NOL12 NOP53 PHF19 RBM15 RNF151 RPS25 SIRT6 SNIP1 TBC1D26 TMA16 TNNT1 TSPYL1 XAGE1A XAGE1B YAP1 ZBTB24 ZBTB48 ZFP1 ZNF280C ZNF286A ZNF329 ZNF524 ZNF687 ZNF775 ZNF835	6 interacting genes: CREBBP CSNK2B H3C1 PRMT2 TK1 TSPYL2
Entrez ID		64061	23135
HPRD ID		06713	18983
Ensembl ID		ENSG00000184205	ENSG00000132510
Uniprot IDs		Q9H2G4	O15054
PDB IDs			2XUE 2XXZ 4ASK 5FP3 5OY3 6F6D
Enriched GO Terms of Interacting Partners?		Nucleus Chromatin Organization Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Nucleolus Regulation Of Primary Metabolic Process Regulation Of Metabolic Process DNA Repair RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA Metabolic Process Chromatin Binding Zinc Ion Binding DNA Damage Response G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Chromatin DNA Binding Transcription Regulator Complex Cyclin B1-CDK1 Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process ESC/E(Z) Complex Positive Regulation Of Chromosome Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cyclin-dependent Protein Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Metal Ion Binding Cellular Response To Stress Telomere Organization Positive Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Histone H3K27me2/H3K27me3 Demethylase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of DNA Repair Protein Localization To Site Of Double-strand Break Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cardiac Muscle Cell Proliferation Cyclin-dependent Protein Serine/threonine Kinase Activity	Chromatin Remodeling Protein-containing Complex Organization Protein-containing Complex Assembly Chromatin Organization Chromatin Binding Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cellular Component Assembly Peptide Lactyltransferase (CoA-dependent) Activity Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Histone H3R8 Methyltransferase Activity Nuclear Progesterone Receptor Binding DNA Synthesis Involved In Mitotic DNA Replication Thymidine Kinase Activity Nucleosome Assembly Nucleosome Organization MRF Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Release From Viral Latency Thymidine Biosynthetic Process Protein-DNA Complex Assembly Positive Regulation Of Activin Receptor Signaling Pathway Negative Regulation Of Viral Life Cycle Protein-arginine Omega-N Asymmetric Methyltransferase Activity Thymidine Metabolic Process RDNA Binding Nucleus Adiponectin-activated Signaling Pathway Nucleoplasm Protein-arginine N-methyltransferase Activity Deoxyribonucleoside Monophosphate Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase I Peroxisome Proliferator Activated Receptor Binding Transcription Coactivator Activity N-terminal Protein Amino Acid Acetylation Chromatin Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Endothelial Tube Morphogenesis Peptidyl-lysine Acetylation Pyrimidine Nucleoside Metabolic Process Regulation Of Cellular Response To Heat Protein Kinase Regulator Activity Nuclear Retinoic Acid Receptor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Acetyltransferase Activity Cellular Response To Lectin
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