TSPYL2 and CEP19

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TSPYL2	CEP19
Description		TSPY like 2	centrosomal protein 19
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Spindle Pole Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Ciliary Basal Body Cell Projection
	Molecular Function	RDNA Binding Chromatin Binding Protein Binding Histone Binding	Protein Binding
	Biological Process	Chromatin Organization Nucleosome Assembly Negative Regulation Of DNA Replication Regulation Of Signal Transduction Negative Regulation Of Cell Growth Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity	Cell Projection Organization Microtubule Anchoring At Centrosome Cilium Assembly Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment
Pathways		XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 31959851)
Interacting Genes		51 interacting genes: ABT1 AEBP2 APTX CASK CCNB1 CDK1 CDK2 CDK4 CEP19 COIL CREBBP CSNK2A1 DYRK1A EEF1A1 EZH2 GFI1B H2BC15 H3C1 HMGXB4 INO80B KDM6A KDM6B KMT5B LMO2 LNX1 MCRS1 NOL12 NOP53 PHF19 RBM15 RNF151 RPS25 SIRT6 SNIP1 TBC1D26 TMA16 TNNT1 TSPYL1 XAGE1A XAGE1B YAP1 ZBTB24 ZBTB48 ZFP1 ZNF280C ZNF286A ZNF329 ZNF524 ZNF687 ZNF775 ZNF835	47 interacting genes: AK4 ANAPC15 CALCOCO1 CCDC102B CCDC106 CCDC74A CDR1 CREB3L2 CREB3L3 EVI5 FOXR1 GMEB2 GNL3 HSPB2 HSPB2-C11orf52 KIAA1958 KXD1 LYSMD2 NOTO PAPSS2 PEX13 PGCKA1 PIBF1 PICK1 PIK3R3 PLEKHO1 PRAP1 PRKAR1B PTPN23 RABL2B REL ROBO4 SENP3 SYNE4 TNNI1 TRAIP TSPYL2 TVP23B TXLNB VCP VPS52 ZBTB10 ZBTB14 ZFP1 ZNF420 ZNF438 ZNF81
Entrez ID		64061	84984
HPRD ID		06713	17488
Ensembl ID		ENSG00000184205	ENSG00000174007
Uniprot IDs		Q9H2G4	A8MX07 Q96LK0
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Chromatin Organization Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Nucleolus Regulation Of Primary Metabolic Process Regulation Of Metabolic Process DNA Repair RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA Metabolic Process Chromatin Binding Zinc Ion Binding DNA Damage Response G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Chromatin DNA Binding Transcription Regulator Complex Cyclin B1-CDK1 Complex Positive Regulation Of Nucleobase-containing Compound Metabolic Process ESC/E(Z) Complex Positive Regulation Of Chromosome Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of DNA Metabolic Process Cyclin-dependent Protein Kinase Activity Regulation Of Cell Cycle G2/M Phase Transition Metal Ion Binding Cellular Response To Stress Telomere Organization Positive Regulation Of RNA Metabolic Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport Histone H3K27me2/H3K27me3 Demethylase Activity Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of DNA Repair Protein Localization To Site Of Double-strand Break Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Cardiac Muscle Cell Proliferation Cyclin-dependent Protein Serine/threonine Kinase Activity
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