STON2 and EPS15

Number of citations of the paper that reports this interaction (PMID 11381094)
45

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		STON2	EPS15
Gene Name		stonin 2	epidermal growth factor receptor pathway substrate 15
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Synaptic Vesicle Cell Junction Clathrin Adaptor Complex Clathrin-coated Vesicle Neuron Projection	Cytoplasm Cytosol Plasma Membrane Coated Pit Membrane AP-2 Adaptor Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Ciliary Membrane
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Polyubiquitin Binding Identical Protein Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Intracellular Protein Transport Regulation Of Endocytosis Synaptic Vesicle Endocytosis	Golgi To Endosome Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Protein Transport Vesicle Organization Endocytic Recycling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly
Pathways			Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	IgE grass sensitization ( 22036096)
Protein-Protein Interactions		6 interactors: AP2M1 EPS15 EPS15L1 ITSN1 SYT1 SYT2	42 interactors: AGFG1 AGFG2 AP2A1 AP2A2 CLINT1 CORO7 CRK DNM1 DNM2 EGFR ELF3 EPN1 EPN2 GRB2 HGS ITSN1 ITSN2 LAPTM5 MOB4 NAGPA NEDD4 NUMB NUMBL OPTN PARK2 REPS2 RNF11 SCAMP1 SNAP91 SPG20 STAM2 STAMBP STON2 SYNJ1 TFAP2A UBB UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBQLN1
Entrez ID		85439	2060
HPRD ID		10531	08968
Ensembl ID		ENSG00000140022	ENSG00000085832
Uniprot IDs		Q8WXE9	B1AUU8 B7Z240 H7BYP0 P42566
PDB IDs		2JXC	1C07 1EH2 1F8H 1FF1 2IV9 2JXC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transport Regulation Of Signaling Ephrin Receptor Signaling Pathway Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synaptic Transmission Synaptic Vesicle Transport Establishment Of Localization In Cell Cell-cell Signaling Establishment Of Vesicle Localization Pathogenesis Vesicle Localization Neurotrophin TRK Receptor Signaling Pathway Calcium Ion-dependent Exocytosis Of Neurotransmitter Neurotrophin Signaling Pathway Cellular Localization Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Establishment Of Organelle Localization Detection Of Calcium Ion Positive Regulation Of Calcium Ion-dependent Exocytosis Cell Surface Receptor Signaling Pathway Signaling Axon Guidance Cell Communication Golgi To Endosome Transport Organelle Localization Positive Regulation Of Vesicle Fusion Negative Regulation Of Protein Localization To Plasma Membrane Endocytic Recycling Glutamate Secretion Regulation Of Defense Response To Virus By Virus Axonogenesis Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Vesicle Fusion Chemotaxis Response To Growth Factor Clathrin Coat Assembly	Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Endocytosis Vesicle-mediated Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein K48-linked Ubiquitination Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Signal Transduction Protein Polyubiquitination Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Cell Communication Transport Post-Golgi Vesicle-mediated Transport Cellular Localization Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Neuron Development Neurotrophin TRK Receptor Signaling Pathway Neuron Projection Development Establishment Of Localization In Cell Neuron Projection Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Neurotrophin Signaling Pathway Intracellular Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Neuron Differentiation Cell Surface Receptor Signaling Pathway Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Cellular Response To Growth Factor Stimulus Establishment Of Protein Localization Response To Growth Factor Regulation Of Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Protein Modification By Small Protein Conjugation Cellular Response To Hypoxia Protein Monoubiquitination Protein Catabolic Process Cellular Response To Decreased Oxygen Levels Receptor Internalization Protein Targeting To Lysosome
Tagcloud ?			6g4 adaptin adaptins ap cerevisiae clathrin coimmunoprecipitated delineated end3 endocytosis glutathione homology immunoprecipitates immunoreactivity kd keeping mammals metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous
Tagcloud (Difference) ?			6g4 adaptin adaptins ap cerevisiae clathrin coimmunoprecipitated delineated end3 endocytosis glutathione homology immunoprecipitates immunoreactivity kd keeping mammals metabolically mu2 nh2 nih3t3 pheromone polypeptides precipitated saccharomyces sets sigma transferase ubiquitous
Tagcloud (Intersection) ?