STON2 and SYT1

Number of citations of the paper that reports this interaction (PMID 11381094)
45

Data Source:
HPRD (in vitro)

		STON2	SYT1
Gene Name		stonin 2	synaptotagmin I
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Synaptic Vesicle Cell Junction Clathrin Adaptor Complex Clathrin-coated Vesicle Neuron Projection	Plasma Membrane Synaptic Vesicle Integral Component Of Membrane Cell Junction Synaptic Vesicle Membrane Dense Core Granule SNARE Complex Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	Protein Binding	SNARE Binding Phosphatidylserine Binding Transporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Phospholipid Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding Syntaxin-1 Binding Clathrin Binding Identical Protein Binding Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Intracellular Protein Transport Regulation Of Endocytosis Synaptic Vesicle Endocytosis	Detection Of Calcium Ion Synaptic Transmission Neurotransmitter Secretion Pathogenesis Glutamate Secretion Synaptic Vesicle Exocytosis Regulation Of Exocytosis Positive Regulation Of Vesicle Fusion Positive Regulation Of Calcium Ion-dependent Exocytosis Vesicle Docking Positive Regulation Of Synaptic Transmission Protein Homooligomerization Regulation Of Synaptic Transmission, Glutamatergic Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway
Pathways			Dopamine Neurotransmitter Release Cycle Toxicity of botulinum toxin type G (BoNT/G) Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: AP2M1 EPS15 EPS15L1 ITSN1 SYT1 SYT2	30 interactors: CACNA1A CACNB3 CACNB4 CALM1 FGF1 GNB2L1 GOLM1 IKBKG IRF3 NEDD4 NR1H3 NR3C1 NRXN1 PPARG RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A ZDHHC17
Entrez ID		85439	6857
HPRD ID		10531	01710
Ensembl ID		ENSG00000140022	ENSG00000067715
Uniprot IDs		Q8WXE9	J3KQA0 P21579
PDB IDs		2JXC	2K45 2K4A 2K8M 2KI6 2LHA 2R83 3F00 3F01 3F04 3F05 4ISQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transport Regulation Of Signaling Ephrin Receptor Signaling Pathway Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synaptic Transmission Synaptic Vesicle Transport Establishment Of Localization In Cell Cell-cell Signaling Establishment Of Vesicle Localization Pathogenesis Vesicle Localization Neurotrophin TRK Receptor Signaling Pathway Calcium Ion-dependent Exocytosis Of Neurotransmitter Neurotrophin Signaling Pathway Cellular Localization Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Establishment Of Organelle Localization Detection Of Calcium Ion Positive Regulation Of Calcium Ion-dependent Exocytosis Cell Surface Receptor Signaling Pathway Signaling Axon Guidance Cell Communication Golgi To Endosome Transport Organelle Localization Positive Regulation Of Vesicle Fusion Negative Regulation Of Protein Localization To Plasma Membrane Endocytic Recycling Glutamate Secretion Regulation Of Defense Response To Virus By Virus Axonogenesis Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Vesicle Fusion Chemotaxis Response To Growth Factor Clathrin Coat Assembly	Cell-cell Signaling Neurotransmitter Transport Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Secretion Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Membrane Synaptic Transmission Vesicle Localization Regulation Of Cellular Localization Exocytosis Regulation Of Signaling Organelle Localization Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Signaling Establishment Of Vesicle Localization Regulation Of Cellular Component Organization Cell Communication Establishment Of Localization In Cell Intracellular Receptor Signaling Pathway Cellular Localization Establishment Of Organelle Localization Vesicle Fusion Vesicle-mediated Transport Membrane Depolarization Membrane Fusion Acid Secretion Regulation Of Vesicle-mediated Transport Protein Localization Regulation Of Protein Localization Regulation Of Membrane Potential Organelle Fusion Regulation Of Secretion Glucocorticoid Receptor Signaling Pathway Regulation Of Immune Response Vesicle Docking Transport Regulation Of Synaptic Transmission Establishment Of Protein Localization Membrane Docking Regulation Of Signal Transduction Positive Regulation Of Synaptic Transmission Calcium Ion-dependent Exocytosis Regulation Of Protein Secretion Regulation Of Cellular Process Cell Differentiation Protein Transport Regulation Of Protein Localization To Plasma Membrane Membrane Organization
Tagcloud ?			carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes
Tagcloud (Difference) ?			carboxyl conformation enriched inactivation localization microdomain microdomains mode must notably orai1 p2 pi pm probe reveals rich saraf scdi septin4 slow stabilized stim1 store terminus tethered tethers translocates undergoes
Tagcloud (Intersection) ?