STON2 and EPS15L1

Number of citations of the paper that reports this interaction (PMID 11381094)
45

Data Source:
HPRD (two hybrid)

		STON2	EPS15L1
Gene Name		stonin 2	epidermal growth factor receptor pathway substrate 15-like 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Cytoplasm Synaptic Vesicle Cell Junction Clathrin Adaptor Complex Clathrin-coated Vesicle Neuron Projection	Nucleus Plasma Membrane Coated Pit Membrane
	Molecular Function	Protein Binding	Calcium Ion Binding Protein Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Intracellular Protein Transport Regulation Of Endocytosis Synaptic Vesicle Endocytosis	Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Pathways			Signaling by EGFR EGFR downregulation Signaling by EGFR in Cancer Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Multiple sclerosis ( 22190364) White blood cell count ( 21738480) White matter integrity ( 23218918)
Protein-Protein Interactions		6 interactors: AP2M1 EPS15 EPS15L1 ITSN1 SYT1 SYT2	8 interactors: AGFG1 AGFG2 EPN1 GNG5 ITSN1 ITSN2 STON2 TRAPPC2B
Entrez ID		85439	58513
HPRD ID		10531	09445
Ensembl ID		ENSG00000140022	ENSG00000127527
Uniprot IDs		Q8WXE9	Q9UBC2
PDB IDs		2JXC
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Vesicle-mediated Transport Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transport Regulation Of Signaling Ephrin Receptor Signaling Pathway Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synaptic Transmission Synaptic Vesicle Transport Establishment Of Localization In Cell Cell-cell Signaling Establishment Of Vesicle Localization Pathogenesis Vesicle Localization Neurotrophin TRK Receptor Signaling Pathway Calcium Ion-dependent Exocytosis Of Neurotransmitter Neurotrophin Signaling Pathway Cellular Localization Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Establishment Of Organelle Localization Detection Of Calcium Ion Positive Regulation Of Calcium Ion-dependent Exocytosis Cell Surface Receptor Signaling Pathway Signaling Axon Guidance Cell Communication Golgi To Endosome Transport Organelle Localization Positive Regulation Of Vesicle Fusion Negative Regulation Of Protein Localization To Plasma Membrane Endocytic Recycling Glutamate Secretion Regulation Of Defense Response To Virus By Virus Axonogenesis Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Vesicle Fusion Chemotaxis Response To Growth Factor Clathrin Coat Assembly	Regulation Of Ras GTPase Activity Endocytosis Regulation Of Ras Protein Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Positive Regulation Of Hydrolase Activity Regulation Of ARF GTPase Activity Regulation Of Signal Transduction Regulation Of ARF Protein Signal Transduction Vesicle-mediated Transport Synaptic Vesicle Transport Synaptic Transmission Positive Regulation Of Catalytic Activity Regulation Of Signaling Regulation Of Intracellular Signal Transduction Establishment Of Vesicle Localization Vesicle Localization Cell-cell Signaling Positive Regulation Of Rho GTPase Activity Regulation Of Rho GTPase Activity Regulation Of Catalytic Activity Establishment Of Organelle Localization Regulation Of Rho Protein Signal Transduction Acrosome Assembly Intermediate Filament Organization Transport Organelle Localization Positive Regulation Of Ras GTPase Activity Regulation Of Cellular Process Spermatid Nucleus Differentiation Positive Regulation Of Metabolic Process
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