STON2 and AP2M1

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)

		STON2	AP2M1
Name		stonin 2	adaptor related protein complex 2 subunit mu 1
Structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Cytosol Synaptic Vesicle Membrane AP-2 Adaptor Complex Neuron Projection Synapse	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Membrane AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Synapse Clathrin-coated Endocytic Vesicle Extracellular Exosome Postsynapse Extrinsic Component Of Presynaptic Endocytic Zone Membrane Glutamatergic Synapse
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Transmembrane Transporter Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding
	Biological Process	Endocytosis Regulation Of Endocytosis Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis	Positive Regulation Of Receptor Internalization Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Protein Transport Vesicle-mediated Transport Receptor Internalization Synaptic Vesicle Endocytosis Protein-containing Complex Assembly Clathrin-dependent Endocytosis Regulation Of Vesicle Size Postsynaptic Neurotransmitter Receptor Internalization Vesicle-mediated Transport In Synapse Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
GWAS		Central corneal thickness ( 29760442 32528159 ) Estimated glomerular filtration rate ( 31152163 ) Metabolite levels ( 23823483 ) Night sleep phenotypes ( 27126917 ) Obesity-related traits ( 23251661 ) Platelet count ( 27863252 32888494 ) Plateletcrit ( 27863252 32888494 ) Prudent dietary pattern ( 28644415 )	Major depressive disorder ( 22472876 )
Novel Interactors		None recorded	10 novel interactors: CKS1B CRIP1 DNAJB11 EIF4G1 ETV5 FGF12 IL1RAP JADE1 LPP XPA
Interacting Genes		8 interacting genes: AP2M1 EPS15 EPS15L1 H19 ITSN1 SYT1 SYT2 UBC	86 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATG9A ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD2BP2 CD3D CDK11B CEBPA CLK2 CORO7 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DPPA2 DVL2 EAF1 EHD2 EIF1AD FAM90A1 FURIN FXR2 GAK GRIN2A GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HOOK2 HTR6 IKZF1 IRS2 KCNJ11 KNOP1 LAMP1 LTB4R2 LUC7L2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 SNCA SPATS2 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TIAM1 TMA16 UBC ZBTB8A ZNF581
Entrez ID		85439	1173
HPRD ID		10531	03014
Ensembl ID		ENSG00000140022	ENSG00000161203
Uniprot IDs		A0A3B3IU55 H0YJ05 Q8WXE9	B4DNB9 E9PFW3 Q96CW1
PDB IDs		2JXC	1H6E 6BNT 6URI
GO Terms Enriched among Interactors		Vesicle-mediated Transport In Synapse Clathrin-coated Pit Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle-mediated Transport Clathrin-coated Endocytic Vesicle Membrane Postsynaptic Neurotransmitter Receptor Internalization Clathrin Coat Of Coated Pit Chromaffin Granule Membrane Postsynaptic Endocytic Zone AP-2 Adaptor Complex Calcium-dependent Activation Of Synaptic Vesicle Fusion Synapse Dense Core Granule Endocytosis Calcium Ion Sensor Activity Positive Regulation Of Dendrite Extension Positive Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Receptor-mediated Endocytosis Low-density Lipoprotein Particle Receptor Binding Exocytic Vesicle Regulation Of Vesicle-mediated Transport Glutamatergic Synapse Clathrin-dependent Endocytosis Calcium Ion Binding Import Into Cell Protein-macromolecule Adaptor Activity Regulation Of Vesicle Fusion Regulation Of Calcium Ion-dependent Exocytosis Endosomal Transport Regulation Of Synaptic Vesicle Exocytosis Calcium-dependent Phospholipid Binding Establishment Of Localization In Cell Vesicle Organization Positive Regulation Of Transport Cytoplasmic Vesicle SNARE Binding Receptor Internalization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Synchronous Neurotransmitter Secretion Endocytic Vesicle Membrane Plasma Membrane Regulation Of Neurotransmitter Secretion Clathrin-dependent Synaptic Vesicle Endocytosis Syntaxin-3 Binding Positive Regulation Of Cellular Component Organization Intracellular Transport Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter	Innate Immune Response In Mucosa Mucosal Immune Response Organ Or Tissue Specific Immune Response Protein-containing Complex Organization Protein-containing Complex Assembly Protein Heterodimerization Activity Structural Constituent Of Chromatin Antibacterial Humoral Response Nucleosome Assembly Protein Domain Specific Binding Nucleosome Nucleosome Organization Protein-DNA Complex Assembly AP-2 Adaptor Complex Import Into Cell Endocytosis Receptor-mediated Endocytosis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Gram-positive Bacterium Synaptic Vesicle Endocytosis Synaptic Vesicle Uncoating Presynaptic Endocytosis Trans-synaptic Signaling Clathrin Adaptor Activity Synaptic Signaling Clathrin Coat Assembly Nucleoplasm Positive Regulation Of Receptor-mediated Endocytosis Clathrin-coated Endocytic Vesicle Antimicrobial Humoral Response Positive Regulation Of Endocytosis Clathrin Coat Disassembly Regulation Of Neuronal Synaptic Plasticity Regulation Of Endocytosis Chemical Synaptic Transmission Excitatory Postsynaptic Potential Regulation Of Presynapse Assembly Regulation Of Presynapse Organization Vesicle Uncoating Nucleus Positive Regulation Of Receptor Internalization Synaptic Membrane Protein Binding Cellular Component Assembly NMDA Glutamate Receptor Activity Synapse Clathrin-dependent Endocytosis Synaptic Vesicle Regulation Of Vesicle-mediated Transport NMDA Selective Glutamate Receptor Complex