RGS8 and PLEKHF2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RGS8	PLEKHF2
Description		regulator of G protein signaling 8	pleckstrin homology and FYVE domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Membrane Cell Projection Perikaryon Synapse	Endosome Early Endosome Endoplasmic Reticulum Endomembrane System Membrane Transport Vesicle Cytoplasmic Vesicle Early Endosome Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	Protein Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Dopamine Receptor Signaling Pathway	Endosome Organization Endosome To Lysosome Transport Protein Transport
Pathways		G alpha (i) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Cigarettes smoked per day in Schizophrenia ( 33691233) Morning person ( 30696823)	Radiation response ( 20923822)
Interacting Genes		7 interacting genes: ADRB2 CCDC85B GOLGA2 HOOK2 KRT40 PLEKHF2 UHMK1	168 interacting genes: ABCG4 ACY3 ADAP1 AIDA AIMP2 ANO9 APP APPL1 ARID4B ARL14EP ASPH BARHL2 BCAS2 BCAS3 BEND7 BLOC1S6 BOD1 BRD7 BSCL2 C1orf35 C3 CAVIN2 CBX8 CCDC146 CCDC172 CCDC25 CCDC85B CDC20B CEP44 CERK CGGBP1 CHCHD2 CHIC2 COX5B CRYBA1 DAZAP2 DMRT3 DNAAF11 DOCK2 DOCK3 DPPA4 DRAP1 DTX2 DUSP4 DUT EIF3C EML2 EXOC7 FAH FBXO28 FBXW5 FGF13 FHL3 FLNA FRMD8 GAGE12G GAGE2E GEM GFER GLUL GNMT GPBP1 GPBP1L1 GRAMD4 GTPBP2 HEBP2 HSPB7 INO80 KCNAB3 KCNJ5-AS1 KRTAP10-10 KRTAP5-4 L3MBTL3 LDOC1 MAGI2 MAP2K1 MAX MBIP MBP MEAF6 MFAP1 MIDN MPP4 MRI1 NDUFA5 NFIA NONO NPM2 NSD2 NUDT2 NUTM1 P2RX7 PACSIN1 PAK1IP1 PDK4 PIK3R3 PPCDC PPP1R18 PRDM14 PRKAG1 PRKAR1A PRPSAP1 PTPN3 PWWP2A RAB28 RABAC1 RADX RARA RASGEF1B RGS10 RGS8 RPAP2 RPE RPRM RPS21 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SAMD11 SCYL1 SEC14L4 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SNRNP35 SOST SPATA24 SPEF1 SPON2 STAMBPL1 SYT16 TBCEL TBX3 TCEANC THAP10 THG1L TNFAIP8 TNFAIP8L1 TP53BP2 TRAF6 TRAM1L1 TRAPPC3 TRIAP1 TRIM22 TSC22D3 TTC9C TXNL4B UBE2Z UGP2 USF1 XCR1 XRN2 YIF1A YY1 ZBTB6 ZDHHC24 ZFYVE26 ZNF165 ZNF250 ZNF263 ZNF398 ZNF439 ZNF581
Entrez ID		85397	79666
HPRD ID		06221	15147
Ensembl ID		ENSG00000135824	ENSG00000175895
Uniprot IDs		P57771	Q9H8W4
PDB IDs		2IHD 2ODE 5DO9
Enriched GO Terms of Interacting Partners?		Endosome To Lysosome Transport Lysosomal Transport Vacuolar Transport Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Endosome Organization Vesicle-mediated Transport Intracellular Transport Beta2-adrenergic Receptor Activity Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Spindle Cellular Localization Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Protein Glycosylation Cytoskeleton FHF Complex Golgi Disassembly Neuronal Ribonucleoprotein Granule Positive Regulation Of Autophagosome Maturation Heat Generation Regulation Of Protein Glycosylation Negative Regulation Of Growth Adrenergic Receptor Activity Importin-alpha Family Protein Binding Delta-catenin Binding Protein Localization To Perinuclear Region Of Cytoplasm Diet Induced Thermogenesis Golgi Ribbon Formation Golgi Cis Cisterna Microtubule Binding	Protein Binding Identical Protein Binding Endoplasmic Reticulum Tubular Network Formation
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