RGS8 and UHMK1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RGS8	UHMK1
Description		regulator of G protein signaling 8	U2AF homology motif kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Membrane Cell Projection Perikaryon Synapse	Nucleus Nucleoplasm Axon Dendrite Cytoplasm Neuronal Ribonucleoprotein Granule
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding	Nucleotide Binding Nucleic Acid Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Ribonucleoprotein Complex Binding Protein Serine Kinase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Dopamine Receptor Signaling Pathway	Peptidyl-serine Phosphorylation Neuron Projection Development Positive Regulation Of Translational Initiation Regulation Of Protein Export From Nucleus Regulation Of Cell Cycle
Pathways		G alpha (i) signalling events G alpha (i) signalling events	Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs
Diseases
GWAS		Cigarettes smoked per day in Schizophrenia ( 33691233) Morning person ( 30696823)	Bone mineral density (femoral neck) ( 27424934) Bone mineral density (total hip) ( 27424934) Discordance in emotional problems in monozygotic twins ( 27043157) Takayasu arteritis ( 25604533)
Interacting Genes		7 interacting genes: ADRB2 CCDC85B GOLGA2 HOOK2 KRT40 PLEKHF2 UHMK1	9 interacting genes: AIRIM DEPDC1B LMO1 NDUFAF3 PAM RGS8 STMN1 TMSB4X TSGA10IP
Entrez ID		85397	127933
HPRD ID		06221	12318
Ensembl ID		ENSG00000135824	ENSG00000152332
Uniprot IDs		P57771	Q8TAS1
PDB IDs		2IHD 2ODE 5DO9
Enriched GO Terms of Interacting Partners?		Endosome To Lysosome Transport Lysosomal Transport Vacuolar Transport Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Endosome Organization Vesicle-mediated Transport Intracellular Transport Beta2-adrenergic Receptor Activity Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Spindle Cellular Localization Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Establishment Of Localization In Cell Positive Regulation Of Protein Glycosylation Cytoskeleton FHF Complex Golgi Disassembly Neuronal Ribonucleoprotein Granule Positive Regulation Of Autophagosome Maturation Heat Generation Regulation Of Protein Glycosylation Negative Regulation Of Growth Adrenergic Receptor Activity Importin-alpha Family Protein Binding Delta-catenin Binding Protein Localization To Perinuclear Region Of Cytoplasm Diet Induced Thermogenesis Golgi Ribbon Formation Golgi Cis Cisterna Microtubule Binding	Peptidylamidoglycolate Lyase Activity Peptidylglycine Monooxygenase Activity Fatty Acid Primary Amide Biosynthetic Process Actin Monomer Sequestering Activity Peptide Amidation Positive Regulation Of Proton-transporting ATP Synthase Activity, Rotational Mechanism Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Supramolecular Fiber Organization Regulation Of GTPase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity Regulation Of Catalytic Activity Negative Regulation Of Protein-containing Complex Assembly Regulation Of T Cell Homeostatic Proliferation Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Ascorbate As One Donor, And Incorporation Of One Atom Of Oxygen Positive Regulation Of Ligase Activity Negative Regulation Of Hematopoietic Stem Cell Differentiation
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