TRIM5 and USP21

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		TRIM5	USP21
Gene Name		tripartite motif containing 5	ubiquitin specific peptidase 21
Image
Gene Ontology Annotations	Cellular Component	Cytoplasmic MRNA Processing Body Cytoplasm Cytosol	Cellular_component Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Signaling Pattern Recognition Receptor Activity Ligase Activity Identical Protein Binding Protein Homodimerization Activity	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding
	Biological Process	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Viral Process Cytokine-mediated Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein Trimerization Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Proteasomal Protein Catabolic Process
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		35 interactors: BTBD1 BTBD2 EWSR1 LZTR1 MKRN3 MNAT1 OTUB2 OTUD6A PCBD1 PRKCG PSMC2 SUMO1 TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 USP15 USP2 USP21 USP39 USP5	43 interactors: ATXN3 BAP1 CBL CBLC DTX3 ESPL1 EXOSC10 HIST2H2AA3 ISG15 JOSD1 KRT40 LRSAM1 OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 STAMBP TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 YOD1
Entrez ID		85363	27005
HPRD ID		07004	05291
Ensembl ID		ENSG00000132256	ENSG00000143258
Uniprot IDs		Q9C035	Q9UK80
PDB IDs		2ECV 2YRG	2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein K48-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Proteasomal Protein Catabolic Process Regulation Of Proteolysis Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Innate Immune Response Protein Deubiquitination Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein Modification By Small Protein Removal Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Defense Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Stress Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Protein K48-linked Deubiquitination Regulation Of Type I Interferon Production Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Protein Ubiquitination Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Protein Modification By Small Protein Removal Protein Deubiquitination Proteolysis Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Protein Metabolic Process Cellular Protein Metabolic Process Protein K48-linked Deubiquitination Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Histone Deubiquitination Metabolic Process Monoubiquitinated Protein Deubiquitination Protein Polyubiquitination Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Communication Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K63-linked Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Protein K11-linked Deubiquitination Regulation Of Cellular Process Signaling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Viral Entry Into Host Cell
Tagcloud ?		antiretroviral antiviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trims tripartite ulk1	4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing
Tagcloud (Difference) ?		antiretroviral antiviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trims tripartite ulk1	4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing
Tagcloud (Intersection) ?