TRIM5 and OTUB2

Number of citations of the paper that reports this interaction (PubMedID 23105109)
42

Data Source:
BioGRID (two hybrid)

		TRIM5	OTUB2
Description		tripartite motif containing 5	OTU deubiquitinase, ubiquitin aldehyde binding 2
Image
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Omegasome	Nucleus
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Binding
	Biological Process	Activation Of Innate Immune Response Immune System Process Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process	Proteolysis Protein Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		Interferon gamma signaling	Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 29212778 33020668) DNA methylation (variation) ( 23725790) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Myocardial infarction ( 33532862) Platelet count ( 32888494 29403010) Serum alkaline phosphatase levels ( 33339817 29403010 33547301) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)	Aspartate aminotransferase levels ( 33547301)
Interacting Genes		49 interacting genes: BTBD1 BTBD2 CFTR DSCR9 EHHADH EWSR1 ITSN1 LGALS8 LZTR1 MKRN3 MNAT1 MPP7 MTURN NTAQ1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 SGTA TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 TSGA10IP UBASH3A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5 YES1	43 interacting genes: APP ARRDC3 CDIP1 CPSF6 DAZAP2 FAM168A GLI2 KRT31 KRT40 LZTS2 MAGEA11 MID1 MID2 MKRN1 NEDD8 PHLDA2 PKM PLEKHB2 PMEPA1 RBCK1 REL RFFL RNF126 SIAH1 SPART TP53BP2 TRAF6 TRIM2 TRIM25 TRIM26 TRIM27 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIP6 U2AF2 UBC UBE2N USP21 USP28
Entrez ID		85363	78990
HPRD ID		07004	07620
Ensembl ID		ENSG00000132256	ENSG00000089723
Uniprot IDs		A0A804HHS7 Q9C035	Q96DC9
PDB IDs		2ECV 2YRG	1TFF 4FJV 5QIO 5QIP 5QIQ 5QIR 5QIS 5QIT 5QIU 5QIV 5QIW 5QIX 5QIY 5QIZ 8CMS
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Metabolic Process Proteolysis Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Cysteine-type Deubiquitinase Activity Protein Deubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process UBC13-MMS2 Complex Regulation Of Post-translational Protein Modification Protein K63-linked Ubiquitination Ubiquitin Conjugating Enzyme Complex Cysteine-type Peptidase Activity Transferase Activity Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Nucleus Positive Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Free Ubiquitin Chain Polymerization Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein K11-linked Deubiquitination Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Error-free Postreplication DNA Repair Positive Regulation Of Protein Modification Process Ubiquitin Binding Catabolic Process Positive Regulation Of Protein Ubiquitination Response To Virus Suppression Of Viral Release By Host Cytosol	Ubiquitin Protein Ligase Activity Post-translational Protein Modification Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Suppression Of Viral Release By Host Protein Modification Process Innate Immune Response Protein K63-linked Ubiquitination Defense Response To Symbiont Defense Response To Other Organism Host-mediated Suppression Of Symbiont Invasion Response To Other Organism Zinc Ion Binding Transferase Activity Ubiquitin-protein Transferase Activity Transcription Coactivator Activity Response To External Biotic Stimulus Positive Regulation Of Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Metabolic Process Canonical NF-kappaB Signal Transduction Defense Response Regulation Of Intracellular Signal Transduction Response To Virus Defense Response To Virus Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Metal Ion Binding Immune Response Positive Regulation Of Signal Transduction Modification-dependent Protein Catabolic Process Cytosol Cytoplasm Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Non-canonical NF-kappaB Signal Transduction Protein K48-linked Ubiquitination Host-mediated Perturbation Of Symbiont Process Negative Regulation Of Viral Transcription Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Modulation Of Process Of Another Organism Regulation Of Viral Transcription Collateral Sprouting In Absence Of Injury Proteasomal Protein Catabolic Process
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