USP21 and CBLC

Number of citations of the paper that reports this interaction (PubMedID 23105109)
42

Data Source:
BioGRID (two hybrid)

		USP21	CBLC
Description		ubiquitin specific peptidase 21	Cbl proto-oncogene C
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Plasma Membrane Membrane Raft
	Molecular Function	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Metal Ion Binding	Phosphotyrosine Residue Binding Ubiquitin-protein Transferase Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Transferase Activity SH3 Domain Binding Receptor Tyrosine Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Chromatin Organization Proteolysis Protein Deubiquitination Ribosome Disassembly Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Rescue Of Stalled Ribosome	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Protein Ubiquitination Regulation Of Signaling Protein Catabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Protein Stabilization Response To Glial Cell Derived Neurotrophic Factor
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases
Drugs
Diseases
GWAS			Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 24507774) Weight ( 28552196)
Interacting Genes		65 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CDC34 CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXD1 FOXM1 H2AC18 H2BC3 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RIPK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2D1 UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 YY1 ZNF350	55 interacting genes: AKT1 BAP1 BIRC2 CCND2 CDK6 CDKN2B CHFR CKM CRK EGFR EPHA2 ERBB2 FGFR4 FYN GLIS2 GRB2 ITCH LATS2 LYN MAP2K3 MDM4 MYC NACAD NF2 NFIC NSD3 OTUD6A OXA1L RAF1 SH3GL3 SHC1 SNCA SPRY2 SRC STK11 TERT TGFB1I1 TP53 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 YES1 ZAP70
Entrez ID		27005	23624
HPRD ID		05291	09765
Ensembl ID		ENSG00000143258	ENSG00000142273
Uniprot IDs		Q9UK80	Q9ULV8
PDB IDs		2Y5B 3I3T 3MTN	3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Removal Protein Modification Process Protein Deubiquitination Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Proteolysis Protein Metabolic Process Peptidase Activity Macromolecule Metabolic Process Protein K48-linked Deubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Deubiquitinase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Cysteine-type Endopeptidase Activity Ubiquitin Protein Ligase Activity Protein K63-linked Deubiquitination Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Catabolic Process K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Protein Polyubiquitination Hydrolase Activity Ubiquitin Protein Ligase Binding Monoubiquitinated Protein Deubiquitination Regulation Of Cellular Response To Stress Ubiquitin Binding TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process TOR Signaling Response To Stress Nucleoplasm DeNEDDylase Activity DNA Damage Response Zinc Ion Binding Negative Regulation Of TOR Signaling Regulation Of Protein Stability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Regulation Of Intracellular Signal Transduction DNA Repair Regulation Of Telomere Maintenance Positive Regulation Of Autophagy Negative Regulation Of Intracellular Signal Transduction	Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Metabolic Process Regulation Of Signal Transduction Proteolysis Regulation Of Protein Modification Process ATP Binding Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Protein Tyrosine Kinase Activity Regulation Of MAPK Cascade Nucleotide Binding Response To Growth Factor Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Metabolic Process Protein Kinase Activity Cell Surface Receptor Signaling Pathway Kinase Activity Cytosol Regulation Of Protein Metabolic Process Protein Polyubiquitination Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Macromolecule Catabolic Process Positive Regulation Of Phosphate Metabolic Process Protein Modification By Small Protein Conjugation Ephrin Receptor Binding Positive Regulation Of Phosphorylation Protein Ubiquitination Nucleus Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Primary Metabolic Process
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