USP21 and ISG15

Number of citations of the paper that reports this interaction (PMID 21399617)
17

Data Source:
BioGRID (enzymatic study)

		USP21	ISG15
Gene Name		ubiquitin specific peptidase 21	ISG15 ubiquitin-like modifier
Image
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleoplasm Cytoplasm Plasma Membrane	Extracellular Region Cytosol
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding	Protein Binding Protein Tag
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Proteasomal Protein Catabolic Process	Viral Process Cytokine-mediated Signaling Pathway Modification-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Regulation Of Interferon-gamma Production Response To Type I Interferon Defense Response To Bacterium Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Erythrocyte Differentiation Defense Response To Virus Type I Interferon Signaling Pathway
Pathways			RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling Antiviral mechanism by IFN-stimulated genes Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ATXN3 BAP1 CBL CBLC DTX3 ESPL1 EXOSC10 HIST2H2AA3 ISG15 JOSD1 KRT40 LRSAM1 OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 STAMBP TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 YOD1	4 interactors: UBA7 UBE2E2 USP18 USP21
Entrez ID		27005	9636
HPRD ID		05291	00958
Ensembl ID		ENSG00000143258	ENSG00000187608
Uniprot IDs		Q9UK80	P05161
PDB IDs		2Y5B 3I3T 3MTN	1Z2M 2HJ8 3PHX 3PSE 3R66 3RT3 3SDL
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Proteolysis Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Protein Metabolic Process Cellular Protein Metabolic Process Protein K48-linked Deubiquitination Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Histone Deubiquitination Metabolic Process Monoubiquitinated Protein Deubiquitination Protein Polyubiquitination Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Communication Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K63-linked Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Protein K11-linked Deubiquitination Regulation Of Cellular Process Signaling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Viral Entry Into Host Cell	ISG15-protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Catabolic Process Cytokine-mediated Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Protein Metabolic Process Histone Deubiquitination Protein Ubiquitination Cellular Response To Cytokine Stimulus Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Proteolysis Response To Cytokine Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Innate Immune Response Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Response To Stress Regulation Of Cytokine-mediated Signaling Pathway Immune Response Defense Response Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Regulation Of Type I Interferon Production Response To Type I Interferon Positive Regulation Of Mitotic Cell Cycle
Tagcloud ?		4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing	arborization asparate blocking branching cns corroborate dendritic dysfunction engagement evident extend glun2a glun2b hand ifnalpha ifnar indicators indirect initially interferon ko neurocognitive neuroinflammation neurotoxic neurotoxicity nmdar partially protect stat1
Tagcloud (Difference) ?		4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing	arborization asparate blocking branching cns corroborate dendritic dysfunction engagement evident extend glun2a glun2b hand ifnalpha ifnar indicators indirect initially interferon ko neurocognitive neuroinflammation neurotoxic neurotoxicity nmdar partially protect stat1
Tagcloud (Intersection) ?