TRIM5 and UBE2V2

Number of citations of the paper that reports this interaction (PubMedID 19549727)
29

Data Source:
BioGRID (two hybrid)

		TRIM5	UBE2V2
Description		tripartite motif containing 5	ubiquitin conjugating enzyme E2 V2
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Omegasome	Nucleus Nucleoplasm Cytoplasm Ubiquitin Conjugating Enzyme Complex UBC13-MMS2 Complex Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Activation Of Innate Immune Response Immune System Process Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process	Protein Polyubiquitination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Protein Ubiquitination Error-free Postreplication DNA Repair Protein K63-linked Ubiquitination Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Double-strand Break Repair
Pathways		Interferon gamma signaling	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 29212778 33020668) DNA methylation (variation) ( 23725790) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Myocardial infarction ( 33532862) Platelet count ( 32888494 29403010) Serum alkaline phosphatase levels ( 33339817 29403010 33547301) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)	Height ( 31562340)
Interacting Genes		49 interacting genes: BTBD1 BTBD2 CFTR DSCR9 EHHADH EWSR1 ITSN1 LGALS8 LZTR1 MKRN3 MNAT1 MPP7 MTURN NTAQ1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 SGTA TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 TSGA10IP UBASH3A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5 YES1	32 interacting genes: BCL10 DZIP3 EGFR HLTF IGSF21 LRIF1 MALT1 MKRN3 MOB4 MUL1 RC3H1 RC3H2 RFFL RNF111 RNF144A RNF2 RNF8 SHPRH SIAH1 SIAH2 STUB1 SUV39H2 TP53 TRAF2 TRIM5 TRIM54 TRIM63 UBC UBE2N UBE3B XIAP ZNRF1
Entrez ID		85363	7336
HPRD ID		07004	04300
Ensembl ID		ENSG00000132256	ENSG00000169139
Uniprot IDs		A0A804HHS7 Q9C035	A0M8W4 Q15819
PDB IDs		2ECV 2YRG	1J74 1J7D 1ZGU 3VON 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 5AIT 7BBD 7BBF 8WR5 9BIV
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Metabolic Process Proteolysis Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Cysteine-type Deubiquitinase Activity Protein Deubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process UBC13-MMS2 Complex Regulation Of Post-translational Protein Modification Protein K63-linked Ubiquitination Ubiquitin Conjugating Enzyme Complex Cysteine-type Peptidase Activity Transferase Activity Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Nucleus Positive Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Free Ubiquitin Chain Polymerization Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein K11-linked Deubiquitination Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Error-free Postreplication DNA Repair Positive Regulation Of Protein Modification Process Ubiquitin Binding Catabolic Process Positive Regulation Of Protein Ubiquitination Response To Virus Suppression Of Viral Release By Host Cytosol	Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Polyubiquitination Post-translational Protein Modification Transferase Activity Protein Modification Process Zinc Ion Binding Ubiquitin Protein Ligase Binding Proteolysis Involved In Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Metal Ion Binding Positive Regulation Of Post-translational Protein Modification Protein K63-linked Ubiquitination Macromolecule Metabolic Process Catabolic Process Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Ubiquitination Ubiquitin Ligase Complex Activation Of Immune Response Regulation Of Protein Ubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Protein Modification Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Immune Response-activating Signaling Pathway Positive Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune Response Immune Response-regulating Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signaling Regulation Of Canonical NF-kappaB Signal Transduction T Cell Receptor Signaling Pathway Immune System Process Polkadots Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process T Cell Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway
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