TRIM5 and TRIM34

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, two hybrid, two hybrid)

		TRIM5	TRIM34
Description		tripartite motif containing 5	tripartite motif containing 34
Image
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Omegasome	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Activation Of Innate Immune Response Immune System Process Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process	Regulation Of Gene Expression Protein Ubiquitination Innate Immune Response Defense Response To Virus Regulation Of Primary Metabolic Process
Pathways		Interferon gamma signaling	Interferon gamma signaling
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 29212778 33020668) DNA methylation (variation) ( 23725790) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Myocardial infarction ( 33532862) Platelet count ( 32888494 29403010) Serum alkaline phosphatase levels ( 33339817 29403010 33547301) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)	Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		49 interacting genes: BTBD1 BTBD2 CFTR DSCR9 EHHADH EWSR1 ITSN1 LGALS8 LZTR1 MKRN3 MNAT1 MPP7 MTURN NTAQ1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 SGTA TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 TSGA10IP UBASH3A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5 YES1	10 interacting genes: BIRC2 MKRN3 MNAT1 TRIM5 UBE2D2 UBE2K UBE2N UBE2U USP2 ZBP1
Entrez ID		85363	53840
HPRD ID		07004	16141
Ensembl ID		ENSG00000132256	ENSG00000258659
Uniprot IDs		A0A804HHS7 Q9C035	Q9BYJ4
PDB IDs		2ECV 2YRG	2EGP
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Metabolic Process Proteolysis Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Cysteine-type Deubiquitinase Activity Protein Deubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process UBC13-MMS2 Complex Regulation Of Post-translational Protein Modification Protein K63-linked Ubiquitination Ubiquitin Conjugating Enzyme Complex Cysteine-type Peptidase Activity Transferase Activity Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Nucleus Positive Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Free Ubiquitin Chain Polymerization Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein K11-linked Deubiquitination Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Error-free Postreplication DNA Repair Positive Regulation Of Protein Modification Process Ubiquitin Binding Catabolic Process Positive Regulation Of Protein Ubiquitination Response To Virus Suppression Of Viral Release By Host Cytosol	Protein Polyubiquitination Post-translational Protein Modification Ubiquitin Conjugating Enzyme Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Protein Modification Process Positive Regulation Of Protein K63-linked Ubiquitination Modification-dependent Protein Catabolic Process Transferase Activity Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Protein Catabolic Process Protein Metabolic Process Regulation Of Protein K63-linked Ubiquitination Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Polyubiquitination Positive Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Innate Immune Response Macromolecule Metabolic Process Regulation Of Immune Response Regulation Of Protein Polyubiquitination Regulation Of Necroptotic Process Macromolecule Catabolic Process Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Catabolic Process Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Immune Response Defense Response To Virus Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Innate Immune Response Ubiquitin Protein Ligase Binding Left-handed Z-DNA Binding Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Response To Cytokine Stimulus Protein K63-linked Ubiquitination Regulation Of Defense Response Nucleus Antiviral Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Modification Process Regulation Of Immune System Process FBXO Family Protein Binding Omegasome Positive Regulation Of Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Virus Ubiquitin Binding
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