TRIM5 and MPP7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRIM5	MPP7
Description		tripartite motif containing 5	MAGUK p55 scaffold protein 7
Image
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Omegasome	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Cortex Membrane Lateral Plasma Membrane Cell Junction Anchoring Junction MPP7-DLG1-LIN7 Complex
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Protein Domain Specific Binding Signaling Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Activation Of Innate Immune Response Immune System Process Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process	Establishment Of Cell Polarity Positive Regulation Of Protein-containing Complex Assembly Bicellular Tight Junction Assembly Protein Localization To Adherens Junction
Pathways		Interferon gamma signaling	RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 29212778 33020668) DNA methylation (variation) ( 23725790) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Myocardial infarction ( 33532862) Platelet count ( 32888494 29403010) Serum alkaline phosphatase levels ( 33339817 29403010 33547301) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)	Achilles tendon injury ( 33606446) Blood protein levels ( 30072576) Bone mineral density ( 24249740) Bone mineral density (paediatric, skull) ( 24945404) Diverticular disease ( 30177863) Femur bone mineral density x serum urate levels interaction ( 34046847) Glaucoma (primary open-angle) ( 27001270) Heel bone mineral density ( 28869591 30598549) Hippocampal volume ( 21116278) Lumbar spine bone mineral density ( 22504420 29499414) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Psychosis and Alzheimer's disease ( 22005930)
Interacting Genes		49 interacting genes: BTBD1 BTBD2 CFTR DSCR9 EHHADH EWSR1 ITSN1 LGALS8 LZTR1 MKRN3 MNAT1 MPP7 MTURN NTAQ1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 SGTA TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 TSGA10IP UBASH3A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5 YES1	7 interacting genes: DLGAP4 HSBP1 LIN7A LIN7B LIN7C MYSM1 TRIM5
Entrez ID		85363	143098
HPRD ID		07004	14733
Ensembl ID		ENSG00000132256	ENSG00000150054
Uniprot IDs		A0A804HHS7 Q9C035	Q5T2T1
PDB IDs		2ECV 2YRG	3LRA 3O46
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Metabolic Process Proteolysis Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Cysteine-type Deubiquitinase Activity Protein Deubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process UBC13-MMS2 Complex Regulation Of Post-translational Protein Modification Protein K63-linked Ubiquitination Ubiquitin Conjugating Enzyme Complex Cysteine-type Peptidase Activity Transferase Activity Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Nucleus Positive Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Free Ubiquitin Chain Polymerization Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein K11-linked Deubiquitination Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Error-free Postreplication DNA Repair Positive Regulation Of Protein Modification Process Ubiquitin Binding Catabolic Process Positive Regulation Of Protein Ubiquitination Response To Virus Suppression Of Viral Release By Host Cytosol	MPP7-DLG1-LIN7 Complex Regulation Of Synaptic Assembly At Neuromuscular Junction Synaptic Vesicle Transport L27 Domain Binding Neurotransmitter Secretion Protein-macromolecule Adaptor Activity Establishment Of Organelle Localization Regulation Of Synapse Organization Neurotransmitter Transport Postsynaptic Density Membrane Establishment Of Vesicle Localization Vesicle Localization Bicellular Tight Junction Organelle Localization Signal Release Regulation Of Synapse Assembly Cell-cell Junction Exocytosis Presynapse Postsynaptic Membrane Basolateral Plasma Membrane Regulation Of Cell Junction Assembly Regulation Of Developmental Growth Synapse Secretion By Cell Anchoring Junction Omegasome Secretion Regulation Of Developmental Process Regulation Of Growth Establishment Of Localization In Cell Cellular Heat Acclimation Histone H2A Deubiquitinase Activity Protein Domain Specific Binding Cholinergic Synapse Postsynaptic Specialization Metal-dependent Deubiquitinase Activity Transcription Coactivator Activity Axonal Transport Of Mitochondrion Suppression Of Viral Release By Host Protein Transport Modification Of Postsynaptic Structure Morphogenesis Of An Epithelial Sheet Regulation Of Hair Follicle Development Regulation Of Viral Entry Into Host Cell Vesicle-mediated Transport Modification Of Synaptic Structure Host-mediated Suppression Of Symbiont Invasion Mitochondrion Transport Along Microtubule Regulation Of Cellular Component Organization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?