USP21 and BAP1

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		USP21	BAP1
Gene Name		ubiquitin specific peptidase 21	BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleoplasm Cytoplasm Plasma Membrane	Nucleus Nucleoplasm Cytoplasm PR-DUB Complex
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding	Chromatin Binding Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Proteasomal Protein Catabolic Process	Regulation Of Cell Growth Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Proliferation Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Monoubiquitinated Histone H2A Deubiquitination Regulation Of Cell Cycle Protein K48-linked Deubiquitination
Pathways
Drugs
Diseases
GWAS			Bipolar disorder ( 21926972)
Protein-Protein Interactions		43 interactors: ATXN3 BAP1 CBL CBLC DTX3 ESPL1 EXOSC10 HIST2H2AA3 ISG15 JOSD1 KRT40 LRSAM1 OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 STAMBP TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 YOD1	10 interactors: BRCA1 HIST2H2AA3 HIST2H2AC TRIM63 UBE2O USP15 USP2 USP21 USP28 YY1
Entrez ID		27005	8314
HPRD ID		05291	04366
Ensembl ID		ENSG00000143258	ENSG00000163930
Uniprot IDs		Q9UK80	Q92560
PDB IDs		2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Proteolysis Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Protein Metabolic Process Cellular Protein Metabolic Process Protein K48-linked Deubiquitination Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Histone Deubiquitination Metabolic Process Monoubiquitinated Protein Deubiquitination Protein Polyubiquitination Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Communication Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K63-linked Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Protein K11-linked Deubiquitination Regulation Of Cellular Process Signaling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Viral Entry Into Host Cell	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Deubiquitination Protein Modification By Small Protein Removal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Response To Radiation Histone Deubiquitination Response To Abiotic Stimulus Cellular Protein Modification Process Regulation Of Proteolysis Proteolysis Cellular Response To UV Response To Light Stimulus Catabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Cellular Protein Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Cellular Protein Metabolic Process Cellular Response To Light Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Histone H3-K9 Acetylation Histone H2B Conserved C-terminal Lysine Deubiquitination Response To Prostaglandin F Signal Transduction By P53 Class Mediator Regulation Of Protein Metabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Response To UV Protein Ubiquitination Cellular Response To Radiation DNA Repair Response To Ionizing Radiation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Modification By Small Protein Conjugation Double-strand Break Repair DNA Damage Checkpoint Cellular Response To Indole-3-methanol Protein Metabolic Process Protein Polyubiquitination Negative Regulation Of Centriole Replication Skeletal Muscle Atrophy
Tagcloud ?		4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing	1000x abstracted arid1a cca cdkn2a cholangiocarcinoma entities extrahepatic fbxw7 fgfr gas hiseq hotspot idh1 illumina indolent intrahepatic introns kras mcl1 ngs pbrm1 pgm presentations radiologic sequencer smad4 targetable worse
Tagcloud (Difference) ?		4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing	1000x abstracted arid1a cca cdkn2a cholangiocarcinoma entities extrahepatic fbxw7 fgfr gas hiseq hotspot idh1 illumina indolent intrahepatic introns kras mcl1 ngs pbrm1 pgm presentations radiologic sequencer smad4 targetable worse
Tagcloud (Intersection) ?