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TRIM5 and UBE2N
Number of citations of the paper that reports this interaction (PubMedID
30503508
)
35
Data Source:
BioGRID
(pull down, enzymatic study)
TRIM5
UBE2N
Description
tripartite motif containing 5
ubiquitin conjugating enzyme E2 N
Image
GO Annotations
Cellular Component
P-body
Nucleus
Cytoplasm
Cytosol
Omegasome
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Ubiquitin Conjugating Enzyme Complex
UBC13-MMS2 Complex
Protein-containing Complex
Extracellular Exosome
Molecular Function
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Protein Kinase Binding
Protein-macromolecule Adaptor Activity
Pattern Recognition Receptor Activity
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Nucleotide Binding
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activator Activity
Biological Process
Activation Of Innate Immune Response
Immune System Process
Autophagy
Regulation Of Gene Expression
Protein Ubiquitination
Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Regulation Of Protein Localization
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of MAPK Cascade
Suppression Of Viral Release By Host
Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Regulation Of Viral Entry Into Host Cell
Host-mediated Suppression Of Symbiont Invasion
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Protein K63-linked Ubiquitination
Regulation Of Primary Metabolic Process
Protein Polyubiquitination
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Repair
Regulation Of DNA Repair
Postreplication Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
DNA Damage Response
Protein Ubiquitination
Cellular Response To Nutrient Levels
TORC1 Signaling
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Repair
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein K63-linked Ubiquitination
Antiviral Innate Immune Response
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of TORC1 Signaling
Positive Regulation Of Double-strand Break Repair
Pathways
Interferon gamma signaling
ISG15 antiviral mechanism
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1-dependent IKK and NF-kappa-B activation
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
PINK1-PRKN Mediated Mitophagy
CLEC7A (Dectin-1) signaling
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
G2/M DNA damage checkpoint
E3 ubiquitin ligases ubiquitinate target proteins
Interleukin-1 signaling
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
Aggrephagy
Aggrephagy
SARS-CoV-2 activates/modulates innate and adaptive immune responses
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Alanine aminotransferase levels (
33547301
)
Apolipoprotein A1 levels (
32203549
)
Apolipoprotein B levels (
32203549
)
Aspartate aminotransferase levels (
33547301
)
Coronary artery disease (
29212778
33020668
)
DNA methylation (variation) (
23725790
)
HDL cholesterol levels (
32203549
)
LDL cholesterol levels (
32203549
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Low density lipoprotein cholesterol levels (
32154731
)
Malaria (
31844061
)
Mean platelet volume (
32888494
27863252
)
Midgestational circulating levels of PBDEs (fetal genetic effect) (
28235828
)
Myocardial infarction (
33532862
)
Platelet count (
32888494
29403010
)
Serum alkaline phosphatase levels (
33339817
29403010
33547301
)
Severe COVID-19 infection with respiratory failure (analysis I) (
32558485
)
Height (
18391951
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
49 interacting genes:
BTBD1
BTBD2
CFTR
DSCR9
EHHADH
EWSR1
ITSN1
LGALS8
LZTR1
MKRN3
MNAT1
MPP7
MTURN
NTAQ1
OTUB2
OTUD6A
PCBD1
PIAS1
PRKCG
PSMC2
RUNX1
SGTA
TNFAIP3
TRIM21
TRIM32
TRIM34
TRIM35
TRIM6
TSGA10IP
UBASH3A
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2H
UBE2K
UBE2N
UBE2U
UBE2V1
UBE2V2
UBE2W
USP15
USP2
USP21
USP39
USP5
YES1
124 interacting genes:
AMFR
ARIH1
ARIH2
ARK2C
AURKA
BARD1
BCL10
BFAR
BIRC2
BIRC3
BIRC8
BRCA1
CADPS2
CBL
CCNB1
CHFR
CHUK
CNOT4
DTL
DTX1
DTX3
DZIP3
F12
H2AC4
HERC2
HSP90AA1
LRSAM1
MALT1
MARCHF5
MARCHF7
MDM2
MIB1
MIB2
MID1
MKRN3
MUL1
MYLIP
NBN
NEDD4L
NEURL1
NFX1
OTUB2
PEDS1
PEDS1-UBE2V1
PELI1
PELI3
PJA2
PRKN
PTTG1
RBCK1
RBX1
RC3H1
RC3H2
RFFL
RFWD3
RIPK1
RNF103
RNF11
RNF111
RNF115
RNF122
RNF125
RNF126
RNF128
RNF13
RNF130
RNF135
RNF152
RNF167
RNF168
RNF181
RNF182
RNF38
RNF4
RNF43
RNF5
RNF8
SH3RF1
SH3RF2
SHPRH
SIAH1
SIAH2
SLC2A4
STUB1
TNFAIP3
TOPORS
TP53
TRAF2
TRAF6
TREX2
TRIM13
TRIM14
TRIM15
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM27
TRIM28
TRIM31
TRIM32
TRIM33
TRIM34
TRIM39
TRIM5
TRIM50
TRIM54
TRIM63
TRIM65
TRIM69
TRIM7
TRIM72
UBA1
UBB
UBE2V1
UBE2V2
UBE3A
UBE3B
UHRF1
XIAP
ZNRF2
ZNRF3
ZNRF4
Entrez ID
85363
7334
HPRD ID
07004
04725
Ensembl ID
ENSG00000132256
ENSG00000177889
Uniprot IDs
A0A804HHS7
Q9C035
P61088
V9HW41
PDB IDs
2ECV
2YRG
1J7D
2C2V
3HCT
3HCU
3VON
3W31
4DHI
4DHJ
4DHZ
4IP3
4NR3
4NRG
4NRI
4ONL
4ONM
4ONN
4ORH
4TKP
4WHV
5AIT
5AIU
5EYA
5H7S
5VNZ
5VO0
5YWR
6D6I
6JKY
6KFP
6KG6
6KL4
6LP2
6P5B
6S53
6ULH
6UMP
6UMS
7BBD
7BBF
7BXG
9BIV
Enriched GO Terms of Interacting Partners
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Post-translational Protein Modification
Protein Modification Process
Protein Modification By Small Protein Conjugation
Protein Ubiquitination
Ubiquitin Conjugating Enzyme Activity
Protein Polyubiquitination
Protein Metabolic Process
Proteolysis
Protein K48-linked Ubiquitination
Ubiquitin-protein Transferase Activity
Cysteine-type Deubiquitinase Activity
Protein Deubiquitination
Proteolysis Involved In Protein Catabolic Process
Macromolecule Metabolic Process
Protein Modification By Small Protein Removal
Modification-dependent Protein Catabolic Process
UBC13-MMS2 Complex
Regulation Of Post-translational Protein Modification
Protein K63-linked Ubiquitination
Ubiquitin Conjugating Enzyme Complex
Cysteine-type Peptidase Activity
Transferase Activity
Macromolecule Catabolic Process
Positive Regulation Of Protein Polyubiquitination
Nucleus
Positive Regulation Of Protein Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Ubiquitin Protein Ligase Activity
Free Ubiquitin Chain Polymerization
Regulation Of Protein Catabolic Process
Regulation Of Proteolysis
Positive Regulation Of Protein K63-linked Ubiquitination
Regulation Of Protein Ubiquitination
Regulation Of Protein Polyubiquitination
Regulation Of Protein Modification Process
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Post-translational Protein Modification
Regulation Of Protein Metabolic Process
Protein K11-linked Deubiquitination
Protein K11-linked Ubiquitination
Proteasomal Protein Catabolic Process
Regulation Of Protein K63-linked Ubiquitination
Error-free Postreplication DNA Repair
Positive Regulation Of Protein Modification Process
Ubiquitin Binding
Catabolic Process
Positive Regulation Of Protein Ubiquitination
Response To Virus
Suppression Of Viral Release By Host
Cytosol
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Transferase Activity
Protein Polyubiquitination
Zinc Ion Binding
Protein Metabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Metabolic Process
Macromolecule Catabolic Process
Metal Ion Binding
Protein K63-linked Ubiquitination
Protein Autoubiquitination
Proteolysis
Catabolic Process
Protein K48-linked Ubiquitination
Response To Stress
Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Post-translational Protein Modification
Regulation Of Protein Ubiquitination
Regulation Of Signal Transduction
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Post-translational Protein Modification
Positive Regulation Of Protein Metabolic Process
Cellular Response To Stress
Regulation Of Intracellular Signal Transduction
Innate Immune Response
Regulation Of Signaling
Regulation Of Cell Communication
Protein Monoubiquitination
Immune System Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Signal Transduction
Defense Response To Symbiont
Cytoplasm
Defense Response To Other Organism
Positive Regulation Of Macromolecule Metabolic Process
Ubiquitin Protein Ligase Binding
Response To Other Organism
Ubiquitin Conjugating Enzyme Binding
Positive Regulation Of Metabolic Process
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Tagcloud (Intersection)
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