USP21 and TRIM9

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		USP21	TRIM9
Gene Name		ubiquitin specific peptidase 21	tripartite motif containing 9
Image
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleoplasm Cytoplasm Plasma Membrane	Cytoplasm Cytoskeleton Synaptic Vesicle Cell Junction Dendrite
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding	SNARE Binding Ubiquitin-protein Transferase Activity Zinc Ion Binding Ligase Activity Protein Homodimerization Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Proteasomal Protein Catabolic Process	Synaptic Vesicle Exocytosis Protein Ubiquitination Negative Regulation Of SNARE Complex Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Calcium Ion-dependent Exocytosis
Pathways			Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ATXN3 BAP1 CBL CBLC DTX3 ESPL1 EXOSC10 HIST2H2AA3 ISG15 JOSD1 KRT40 LRSAM1 OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 STAMBP TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 YOD1	28 interactors: AP3M1 BTRC CHFR CSNK1D CWF19L2 DTNBP1 DTX3L EVL EXOC1 GFM2 LONRF1 MDM2 MNAT1 MUL1 NCF1 NFKBID PCGF3 RNF166 RPL4P5 SNAP25 SPG21 TRIM27 TRIM46 TRIM8 TSSK3 USP2 USP21 VASP
Entrez ID		27005	114088
HPRD ID		05291	05947
Ensembl ID		ENSG00000143258	ENSG00000100505
Uniprot IDs		Q9UK80	Q9C026
PDB IDs		2Y5B 3I3T 3MTN	2DB8
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Proteolysis Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Protein Metabolic Process Cellular Protein Metabolic Process Protein K48-linked Deubiquitination Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Histone Deubiquitination Metabolic Process Monoubiquitinated Protein Deubiquitination Protein Polyubiquitination Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Communication Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K63-linked Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Protein K11-linked Deubiquitination Regulation Of Cellular Process Signaling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Viral Entry Into Host Cell	Protein Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Protein Modification By Small Protein Conjugation Organelle Organization Regulation Of Protein Stability Cellular Protein Metabolic Process Cellular Protein Modification Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Regulation Of Viral Transcription Protein Complex Assembly Protein Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Release From Host Cell Regulation Of Circadian Rhythm Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Actin Filament Polymerization Cellular Macromolecule Catabolic Process Synaptic Vesicle Transport Anterograde Synaptic Vesicle Transport Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Viral Transcription Positive Regulation Of Proteolysis Regulation Of Viral Release From Host Cell Cellular Protein Catabolic Process Positive Regulation Of Protein Polymerization G2/M Transition Of Mitotic Cell Cycle Protein Destabilization Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Catabolic Process Anterograde Axon Cargo Transport Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Viral Process Mitotic Cell Cycle Process Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Positive Regulation Of Protein Complex Assembly Positive Regulation Of Organelle Organization Circadian Rhythm Regulation Of Actin Filament Polymerization Organelle Localization Mitotic Cell Cycle Cellular Response To UV-C Cellular Response To Vitamin B1 Posttranscriptional Regulation Of Gene Expression Regulation Of Protein Metabolic Process Positive Regulation Of Cytoskeleton Organization Establishment Of Vesicle Localization
Tagcloud ?		4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing	alteration alterations arf cadps2 frequently gain genomic hot ink4a instability mutants mutation mutations obvious p16 p53 piwil4 point prepared reason restraining resulting saos specificity spot suppresses suppressor transcriptional tumors
Tagcloud (Difference) ?		4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing	alteration alterations arf cadps2 frequently gain genomic hot ink4a instability mutants mutation mutations obvious p16 p53 piwil4 point prepared reason restraining resulting saos specificity spot suppresses suppressor transcriptional tumors
Tagcloud (Intersection) ?