USP21 and USP33

Number of citations of the paper that reports this interaction (PubMedID 22626734)
34

Data Source:
BioGRID (enzymatic study)

		USP21	USP33
Description		ubiquitin specific peptidase 21	ubiquitin specific peptidase 33
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Focal Adhesion VCB Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity DeNEDDylase Activity Metal Ion Binding	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Small GTPase Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Chromatin Organization Proteolysis Protein Deubiquitination Ribosome Disassembly Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Rescue Of Stalled Ribosome	Proteolysis Ubiquitin-dependent Protein Catabolic Process Endocytosis Nervous System Development Axon Guidance Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Migration Protein Deubiquitination Protein Stabilization Centrosome Duplication Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of Autophagosome Assembly
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Ub-specific processing proteases	Ub-specific processing proteases Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS			Adult body size ( 32376654) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		65 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CDC34 CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXD1 FOXM1 H2AC18 H2BC3 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RIPK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2D1 UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 YY1 ZNF350	17 interacting genes: CCP110 CHRM5 DDX56 DIO2 DSCR9 EIF6 ELOC PRKN SELENBP1 SNCA TRIM54 TRIM63 UBC USP15 USP21 USP28 VHL
Entrez ID		27005	23032
HPRD ID		05291	10297
Ensembl ID		ENSG00000143258	ENSG00000077254
Uniprot IDs		Q9UK80	Q8TEY7
PDB IDs		2Y5B 3I3T 3MTN	2UZG
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification By Small Protein Removal Protein Modification Process Protein Deubiquitination Cysteine-type Deubiquitinase Activity Cysteine-type Peptidase Activity Proteolysis Protein Metabolic Process Peptidase Activity Macromolecule Metabolic Process Protein K48-linked Deubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Deubiquitinase Activity Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Cysteine-type Endopeptidase Activity Ubiquitin Protein Ligase Activity Protein K63-linked Deubiquitination Ubiquitin-protein Transferase Activity Ubiquitin-dependent Protein Catabolic Process Catabolic Process Protein Catabolic Process K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity Protein Polyubiquitination Hydrolase Activity Ubiquitin Protein Ligase Binding Monoubiquitinated Protein Deubiquitination Regulation Of Cellular Response To Stress Ubiquitin Binding TORC1 Signaling Negative Regulation Of TORC1 Signaling Proteasomal Protein Catabolic Process TOR Signaling Response To Stress Nucleoplasm DeNEDDylase Activity DNA Damage Response Zinc Ion Binding Negative Regulation Of TOR Signaling Regulation Of Protein Stability Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of TORC1 Signaling Regulation Of Intracellular Signal Transduction DNA Repair Regulation Of Telomere Maintenance Positive Regulation Of Autophagy Negative Regulation Of Intracellular Signal Transduction	Post-translational Protein Modification Dopamine Transport Monoamine Transport Protein Deubiquitination Amyloid Fibril Formation Protein Modification By Small Protein Removal Target-directed MiRNA Degradation Elongin Complex Protein Modification Process Dopamine Uptake Involved In Synaptic Transmission Protein Ubiquitination Protein Metabolic Process Selenium Binding Protein Modification By Small Protein Conjugation Catecholamine Uptake Dopamine Uptake Regulation Of ATP Metabolic Process MiRNA Catabolic Process Phenol-containing Compound Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Proteolysis Synaptic Transmission, Dopaminergic Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Cul5-RING Ubiquitin Ligase Complex Cysteine-type Deubiquitinase Activity Macromolecule Metabolic Process Cul2-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Neurotransmitter Reuptake Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Metabolic Process Phospholipase Binding Regulation Of Phosphorus Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Dopamine Secretion MiRNA Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of MiRNA-mediated Gene Silencing Cysteine-type Peptidase Activity Deubiquitinase Activity Post-transcriptional Gene Silencing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Post-transcriptional Gene Silencing Neurotransmitter Uptake Regulation Of Synaptic Vesicle Recycling Cytosol Dopamine Metabolic Process Regulation Of Protein Stability
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