TRIM5 and PIAS1

Number of citations of the paper that reports this interaction (PubMedID 25880753)
13

Data Source:
BioGRID (enzymatic study)

		TRIM5	PIAS1
Description		tripartite motif containing 5	protein inhibitor of activated STAT 1
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GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Omegasome	Chromatin Nucleus Nucleoplasm Cytoplasm Cytoskeleton PML Body Nuclear Speck Nuclear Periphery Glutamatergic Synapse Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Cis-regulatory Region Binding DNA Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Transferase Activity SUMO Transferase Activity Enzyme Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Metal Ion Binding SUMO Ligase Activity DNA-binding Transcription Factor Binding
	Biological Process	Activation Of Innate Immune Response Immune System Process Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Regulation Of Transcription By RNA Polymerase II DNA Damage Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Visual Learning Protein Sumoylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Sumoylation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Smooth Muscle Cell Differentiation Regulation Of Macromolecule Metabolic Process Protein-DNA Complex Assembly Positive Regulation Of Protein Localization To Cell Periphery
Pathways		Interferon gamma signaling	SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins Formation of Incision Complex in GG-NER Regulation of IFNG signaling
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 29212778 33020668) DNA methylation (variation) ( 23725790) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Myocardial infarction ( 33532862) Platelet count ( 32888494 29403010) Serum alkaline phosphatase levels ( 33339817 29403010 33547301) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)	Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Haemorrhoidal disease ( 33888516) Major depressive disorder ( 23377640) Number of twin births ( 30760885)
Interacting Genes		49 interacting genes: BTBD1 BTBD2 CFTR DSCR9 EHHADH EWSR1 ITSN1 LGALS8 LZTR1 MKRN3 MNAT1 MPP7 MTURN NTAQ1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 SGTA TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 TSGA10IP UBASH3A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5 YES1	118 interacting genes: AKT1 AR ATXN1 AXIN1 BARD1 BRCA1 CASP8 CBS CDK4 CEBPA CEBPE CHD3 CHUK CNOT7 CREB1 CREBBP CSNK2A1 CSRP2 DCLRE1A DDX21 DDX5 DNM1 DNMT3A ELK3 EP300 ERG ESR1 ESR2 FANCI FHL3 FLI1 GATA4 GLUL GRM8 GSK3B GTF2IRD1 H2AZ1 H2BC3 H3C1 HECTD2 HIC1 HTT IKZF5 JUN L3MBTL2 LSM3 MAML1 MBD1 MDC1 MDM2 MITF MORC3 MSX1 MX1 MYB NCOR1 NFATC1 NIN NR2F2 NR3C2 NR5A1 NRIP1 PAXIP1 PGR PIAS2 PIAS4 PLAG1 PML PPP1CA PPP1CC PRDM1 PRPF40A PTK2 PTPN1 QKI RAD51 RAD54L2 RBBP6 RELA RHOB RPA2 SATB1 SATB2 SERBP1 SETX SGTA SKIL SMAD1 SMAD4 SMAD7 SNAI2 SNIP1 SP3 SPOP SREBF2 STAT1 SUFU SUMO1 SUMO1P1 SUMO2 SUMO3 TBP TERF2 TERF2IP TEX11 TP53 TP73 TRIM27 TRIM5 TRIM55 TRIM63 TSG101 UBE2I UBE2L3 YWHAZ ZBED1 ZNF451 ZNF76
Entrez ID		85363	8554
HPRD ID		07004	16029
Ensembl ID		ENSG00000132256	ENSG00000033800
Uniprot IDs		A0A804HHS7 Q9C035	O75925
PDB IDs		2ECV 2YRG	1V66
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Protein Modification Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Metabolic Process Proteolysis Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Cysteine-type Deubiquitinase Activity Protein Deubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process UBC13-MMS2 Complex Regulation Of Post-translational Protein Modification Protein K63-linked Ubiquitination Ubiquitin Conjugating Enzyme Complex Cysteine-type Peptidase Activity Transferase Activity Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Nucleus Positive Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Free Ubiquitin Chain Polymerization Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein K11-linked Deubiquitination Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Error-free Postreplication DNA Repair Positive Regulation Of Protein Modification Process Ubiquitin Binding Catabolic Process Positive Regulation Of Protein Ubiquitination Response To Virus Suppression Of Viral Release By Host Cytosol	Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression DNA Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Chromatin PML Body Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Enzyme Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Sumoylation Macromolecule Metabolic Process Ubiquitin Protein Ligase Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Stress Cellular Response To Stress RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Cellular Response To Stress Nucleic Acid Metabolic Process Chromatin Binding Intracellular Signal Transduction SUMO Transferase Activity
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