USP21 and OTUB2

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		USP21	OTUB2
Gene Name		ubiquitin specific peptidase 21	OTU deubiquitinase, ubiquitin aldehyde binding 2
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Gene Ontology Annotations	Cellular Component	Cellular_component Nucleoplasm Cytoplasm Plasma Membrane	Nucleus
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding	Ubiquitin-specific Protease Activity
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Proteasomal Protein Catabolic Process	Proteolysis Protein Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ATXN3 BAP1 CBL CBLC DTX3 ESPL1 EXOSC10 HIST2H2AA3 ISG15 JOSD1 KRT40 LRSAM1 OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 STAMBP TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 YOD1	33 interactors: APP ARRDC3 CPSF6 FAM168A KRT31 KRT40 LZTS2 MAGEA11 MID1 MID2 PJA1 RBCK1 REL RFFL RNF126 SIAH1 TP53BP2 TRAF6 TRIM2 TRIM25 TRIM26 TRIM27 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIP6 UBC UBE2N USP21 USP28
Entrez ID		27005	78990
HPRD ID		05291	07620
Ensembl ID		ENSG00000143258	ENSG00000089723
Uniprot IDs		Q9UK80	Q96DC9
PDB IDs		2Y5B 3I3T 3MTN	1TFF 4FJV
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Proteolysis Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Protein Metabolic Process Cellular Protein Metabolic Process Protein K48-linked Deubiquitination Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Histone Deubiquitination Metabolic Process Monoubiquitinated Protein Deubiquitination Protein Polyubiquitination Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Communication Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K63-linked Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Protein K11-linked Deubiquitination Regulation Of Cellular Process Signaling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Viral Entry Into Host Cell	Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Viral Release From Host Cell Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Viral Release From Host Cell Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Negative Regulation Of Viral Entry Into Host Cell Regulation Of Signal Transduction Protein Polyubiquitination Regulation Of Viral Entry Into Host Cell Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling Cellular Protein Modification Process Negative Regulation Of Viral Process Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Response To Cytokine Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Immune Response Defense Response Regulation Of Viral Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Cytokine-mediated Signaling Pathway Regulation Of Intracellular Signal Transduction Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Cytokine Stimulus Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Locomotion Immune System Process I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interferon-gamma Signal Transduction Regulation Of Locomotion Response To Interferon-gamma Negative Regulation Of Viral Transcription Protein Metabolic Process Signaling Regulation Of Cellular Process Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Tagcloud ?		4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing	antiviral attenuation coimmunoprecipitations deubiquitinating deubiquitination e3 emerged enzymes ifn ifnb1 induction interacted interferon irf3 knockdown ligases negatively opposite otub1 regulate regulators regulatory traf3 traf6 translational triggered ubiquitin ubiquitination virus
Tagcloud (Difference) ?		4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing	antiviral attenuation coimmunoprecipitations deubiquitinating deubiquitination e3 emerged enzymes ifn ifnb1 induction interacted interferon irf3 knockdown ligases negatively opposite otub1 regulate regulators regulatory traf3 traf6 translational triggered ubiquitin ubiquitination virus
Tagcloud (Intersection) ?