USP21 and USP51

Number of citations of the paper that reports this interaction (PMID 22626734)
2

Data Source:
BioGRID (enzymatic study)

		USP21	USP51
Gene Name		ubiquitin specific peptidase 21	ubiquitin specific peptidase 51
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cellular_component Nucleoplasm Cytoplasm Plasma Membrane	SAGA Complex
	Molecular Function	Transcription Coactivator Activity Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Zinc Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Histone Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Proteasomal Protein Catabolic Process	Regulation Of Transcription, DNA-templated Histone Deubiquitination Protein Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ATXN3 BAP1 CBL CBLC DTX3 ESPL1 EXOSC10 HIST2H2AA3 ISG15 JOSD1 KRT40 LRSAM1 OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 STAMBP TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 YOD1	4 interactors: PJA1 USP15 USP21 USP28
Entrez ID		27005	158880
HPRD ID		05291	07167
Ensembl ID		ENSG00000143258	ENSG00000247746
Uniprot IDs		Q9UK80	Q70EK9
PDB IDs		2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Removal Protein Deubiquitination Proteolysis Modification-dependent Protein Catabolic Process Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Modification Process Protein Metabolic Process Cellular Protein Metabolic Process Protein K48-linked Deubiquitination Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cellular Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Histone Deubiquitination Metabolic Process Monoubiquitinated Protein Deubiquitination Protein Polyubiquitination Regulation Of Protein Ubiquitination Regulation Of Metabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Communication Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K63-linked Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Protein K11-linked Deubiquitination Regulation Of Cellular Process Signaling Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Viral Entry Into Host Cell	Protein Deubiquitination Protein Catabolic Process Protein Modification By Small Protein Removal Regulation Of Proteasomal Protein Catabolic Process Histone Deubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Proteolysis Cellular Macromolecule Catabolic Process Histone H2B Conserved C-terminal Lysine Deubiquitination Cellular Protein Modification Process Proteolysis Cellular Protein Metabolic Process Monoubiquitinated Protein Deubiquitination Histone Modification Regulation Of Cellular Protein Metabolic Process Pathway-restricted SMAD Protein Phosphorylation Protein K48-linked Deubiquitination Protein K63-linked Deubiquitination Regulation Of Protein Metabolic Process Protein Metabolic Process Chromatin Modification Chromatin Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To UV Chromosome Organization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Cellular Response To Light Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Tagcloud ?		4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing
Tagcloud (Difference) ?		4alpha chromatin concomitant deacetylase deacetylation details determines dimethylation dysregulation glycogen grb14 hepatocyte hnf hypothesis interpretation latter lys14 lys4 lys9 mediator nucleosomes pea15 ped proximal remodelling represses scaffold serves silencing
Tagcloud (Intersection) ?