LEPR and CSNK2B

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		LEPR	CSNK2B
Gene Name		leptin receptor	casein kinase 2, beta polypeptide
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Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane Receptor Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex PcG Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Identical Protein Binding	Protein Serine/threonine Kinase Activity Receptor Binding Protein Binding Transcription Factor Binding Protein Kinase Regulator Activity Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Energy Reserve Metabolic Process Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Cholesterol Metabolic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Gluconeogenesis Negative Regulation Of Hydrolase Activity	Mitotic Cell Cycle Protein Phosphorylation Signal Transduction Axon Guidance Negative Regulation Of Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Wnt Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Adiponectin-activated Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Cellular Protein Complex Assembly Regulation Of Protein Kinase Activity Regulation Of DNA Binding Endothelial Tube Morphogenesis
Pathways			Mitotic Prometaphase Signal transduction by L1 Axon guidance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling L1CAM interactions Signaling by Wnt Cell Cycle, Mitotic M Phase WNT mediated activation of DVL TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN Signaling by WNT in cancer Condensation of Prometaphase Chromosomes
Drugs
Diseases
GWAS		C-reactive protein ( 19567438 18439548 21300955 22939635) Metabolic traits ( 19060910) Obesity (early onset extreme) ( 23563609) Soluble leptin receptor levels ( 20167575)
Protein-Protein Interactions		16 interactors: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 XRN1	175 interactors: ABHD4 ACTB ACTL6B ACTR1B ACTR5 ACVRL1 ADD1 ADH5 ADRBK1 ANGPT2 ANKRD28 AP2M1 APLP1 ARAF ATF1 ATG101 ATXN3 BAG6 BCCIP BID BMI1 BRCA1 BTF3 C6orf136 C9orf114 CACNA1A CALM1 CBX4 CCDC115 CCNH CD163 CD81 CDC25B CDC34 CDK1 CDK20 CDKN1A CENPB CHEK1 CHRNA4 CIC COIL COL4A2 COPS2 COPS3 COPS7A CPNE7 CPSF3L CSN1S1 CSN2 CSNK2A1 CSNK2A2 CTDP1 CTNNB1 DACT1 DALRD3 DENND5A DNMT1 EIF2S2 EIF5 EIF6 EPS8 ERCC8 ESR1 FAF1 FBXL5 FGB FGF1 FGF2 FIBP FKBP3 FTH1 GADD45GIP1 GAMT GBP2 GLB1 GNB5 HEXB HIRIP3 HNRNPA2B1 HOXB6 HTRA1 IER3IP1 IRS1 ITSN1 JUN KDM6B KIF2C LCK LEPR LMO4 LRP5L LYN LYST MAPK14 MBD4 MGEA5 MME MOXD1 MPP2 NAP1L1 NCF1 NMT2 NOLC1 NOTCH3 NRBP1 ODC1 PDS5A PFKFB4 PHC2 PHF11 PHRF1 PIN1 PITPNA PLXNA3 POT1 PPID PPP3CC PRKAB2 PRKCZ PRNP PROC PTPRK PYROXD2 RFC1 RNF126 RNF7 RPA1 RPL13 RPL41 RPL5 RPS6KA2 RPS6KA5 RPS6KB1 RPS6KB2 RRAD RXRA SARNP SDHA SEC11A SHANK3 SHMT1 SHMT2 SIMC1 SIRT1 SNX2 SPSB3 SSB STAT5A STAU1 STK16 SUMO2 SYNE4 TCEAL7 TCTEX1D2 TLE1 TNFAIP1 TOP2B TP53 TP53BP2 TSEN54 TUBB2B UBE2I UPF1 USO1 UTP14A VDAC1 VRK3 WDR1 WDR18 WFIKKN1 ZNF44 ZNF71 ZNF784 ZNHIT1
Entrez ID		3953	1460
HPRD ID		03001	00278
Ensembl ID		ENSG00000116678	ENSG00000204435
Uniprot IDs		P48357 Q4G138	N0E4C7 P67870 Q5SRQ6
PDB IDs		3V6O	1DS5 1JWH 1QF8 3EED 4DGL
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Phosphorylation JAK-STAT Cascade Cellular Response To Cytokine Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Response To Cytokine Regulation Of Protein Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Negative Regulation Of Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Locomotion Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Hormone Secretion Regulation Of Immune System Process Protein Transport Cellular Response To Hormone Stimulus Establishment Of Protein Localization Regulation Of Cell Motility Response To Growth Hormone Regulation Of Locomotion Regulation Of Cellular Component Movement Lamellipodium Morphogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Regulation Of Kinase Activity Negative Regulation Of Cell Migration Endosomal Transport Response To Peptide Hormone Retrograde Transport, Endosome To Golgi Vesicle Organization Regulation Of Cell Activation Regulation Of Nucleocytoplasmic Transport Protein Localization Response To Peptide Positive Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Tyrosine Phosphorylation Of STAT Protein Establishment Of Localization In Cell Positive Regulation Of Protein Modification Process	Cellular Metabolic Process Response To Growth Factor Regulation Of Protein Metabolic Process Cellular Response To Growth Factor Stimulus Developmental Process Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Multicellular Organismal Development Regulation Of Cell Proliferation Anatomical Structure Development Metabolic Process Response To Organic Substance Regulation Of Cellular Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Macromolecule Biosynthetic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Cycle Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process System Development Response To Stress Neurotrophin TRK Receptor Signaling Pathway Response To Stimulus Cell Cycle Positive Regulation Of Protein Metabolic Process Neurotrophin Signaling Pathway Nitrogen Compound Metabolic Process Biosynthetic Process Cellular Protein Modification Process Cellular Response To Stimulus Cell Death Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Death Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Radiation Response To Radiation Positive Regulation Of Cell Proliferation Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Apoptotic Process Cellular Response To Light Stimulus Gene Expression Regulation Of Phosphorylation Peptidyl-amino Acid Modification Programmed Cell Death Cellular Aromatic Compound Metabolic Process
Tagcloud ?		augmentation avenue confounded constitute conversely cre detrimental dissociation functionally hypothalamic hypothalamus isolating locomotor melanocortin neuroanatomically neurochemically neuron obesity opiomelanocortin pomc pomcneo reactivatable recombinase restrict severely subpopulations therapeutically thirds utilized	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Difference) ?		augmentation avenue confounded constitute conversely cre detrimental dissociation functionally hypothalamic hypothalamus isolating locomotor melanocortin neuroanatomically neurochemically neuron obesity opiomelanocortin pomc pomcneo reactivatable recombinase restrict severely subpopulations therapeutically thirds utilized	bovine casein catalytic cattle chromosome chromosomes coast composed conserved defined east encoding fever genomes homology hybrid mapped panel parasitic polymerase rodent segment somatic subunit subunits synteny theileriosis
Tagcloud (Intersection) ?