LEPR and LEP

Number of citations of the paper that reports this interaction (PMID 8608603)
252

Data Source:
HPRD (in vivo)

		LEPR	LEP
Gene Name		leptin receptor	leptin
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane Receptor Complex	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Identical Protein Binding	Hormone Activity Growth Factor Activity Peptide Hormone Receptor Binding
	Biological Process	Energy Reserve Metabolic Process Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Cholesterol Metabolic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Gluconeogenesis Negative Regulation Of Hydrolase Activity	Negative Regulation Of Transcription From RNA Polymerase II Promoter Ovulation From Ovarian Follicle Response To Hypoxia Positive Regulation Of Cytokine Production Placenta Development Response To Dietary Excess Glucose Metabolic Process Regulation Of Gluconeogenesis Energy Reserve Metabolic Process Glycerol Biosynthetic Process Fatty Acid Beta-oxidation Tyrosine Phosphorylation Of STAT Protein Female Pregnancy Circadian Rhythm Cholesterol Metabolic Process Bile Acid Metabolic Process Regulation Of Blood Pressure Positive Regulation Of Cell Proliferation Adult Feeding Behavior Central Nervous System Neuron Development Insulin Secretion Regulation Of Intestinal Cholesterol Absorption Negative Regulation Of Appetite Response To Insulin Response To Vitamin E Leptin-mediated Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Bone Mineralization Involved In Bone Maturation Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Glucose Homeostasis Eating Behavior Negative Regulation Of Apoptotic Process Positive Regulation Of Ion Transport Positive Regulation Of MAPK Cascade Regulation Of Fat Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Negative Regulation Of Vasoconstriction Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Developmental Growth Regulation Of Insulin Secretion Regulation Of Steroid Biosynthetic Process Leukocyte Tethering Or Rolling Regulation Of Lipoprotein Lipid Oxidation Adipose Tissue Development Negative Regulation Of Cartilage Development Negative Regulation Of Glucagon Secretion Cellular Response To L-ascorbic Acid Cellular Response To Retinoic Acid Positive Regulation Of STAT Protein Import Into Nucleus Negative Regulation Of Glutamine Transport Positive Regulation Of Hepatic Stellate Cell Activation
Pathways			Peptide hormone metabolism Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Signaling by Leptin Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS		C-reactive protein ( 19567438 18439548 21300955 22939635) Metabolic traits ( 19060910) Obesity (early onset extreme) ( 23563609) Soluble leptin receptor levels ( 20167575)
Protein-Protein Interactions		16 interactors: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 XRN1	10 interactors: A2M CLU CRP GHRL HK3 LEPR PRKAA2 SIGLEC6 STAT3 UCN
Entrez ID		3953	3952
HPRD ID		03001	01249
Ensembl ID		ENSG00000116678	ENSG00000174697
Uniprot IDs		P48357 Q4G138	A4D0Y8 P41159
PDB IDs		3V6O	1AX8
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Phosphorylation JAK-STAT Cascade Cellular Response To Cytokine Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Response To Cytokine Regulation Of Protein Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Negative Regulation Of Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Locomotion Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Hormone Secretion Regulation Of Immune System Process Protein Transport Cellular Response To Hormone Stimulus Establishment Of Protein Localization Regulation Of Cell Motility Response To Growth Hormone Regulation Of Locomotion Regulation Of Cellular Component Movement Lamellipodium Morphogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Regulation Of Kinase Activity Negative Regulation Of Cell Migration Endosomal Transport Response To Peptide Hormone Retrograde Transport, Endosome To Golgi Vesicle Organization Regulation Of Cell Activation Regulation Of Nucleocytoplasmic Transport Protein Localization Response To Peptide Positive Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Tyrosine Phosphorylation Of STAT Protein Establishment Of Localization In Cell Positive Regulation Of Protein Modification Process	Positive Regulation Of Corticotropin Secretion Regulation Of Corticotropin Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Feeding Behavior Response To Organic Substance Generation Of Precursor Metabolites And Energy Negative Regulation Of Cell Death Regulation Of Response To Food Regulation Of Carbohydrate Metabolic Process Regulation Of Appetite Regulation Of Cellular Ketone Metabolic Process Protein Activation Cascade Regulation Of Cytokine Production Regulation Of Glycolytic Process Regulation Of Signaling Negative Regulation Of Signaling Negative Regulation Of Cellular Metabolic Process Glucose Homeostasis Response To Estrogen Secretion Transport Acute-phase Response Regulation Of Vasodilation Regulation Of Cell Death Energy Derivation By Oxidation Of Organic Compounds Positive Regulation Of Cellular Metabolic Process Lipid Transport Signaling Lipid Localization Chemical Homeostasis Neurogenesis Negative Regulation Of Hormone Secretion Cell Communication Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Platelet Degranulation Negative Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Regulation Of Generation Of Precursor Metabolites And Energy Response To Hormone Acute Inflammatory Response Positive Regulation Of Tau-protein Kinase Activity Cortisol Secretion Regulation Of Neuronal Signal Transduction Negative Regulation Of Growth Hormone Receptor Signaling Pathway Microglial Cell Proliferation Response To External Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion
Tagcloud ?		augmentation avenue confounded constitute conversely cre detrimental dissociation functionally hypothalamic hypothalamus isolating locomotor melanocortin neuroanatomically neurochemically neuron obesity opiomelanocortin pomc pomcneo reactivatable recombinase restrict severely subpopulations therapeutically thirds utilized	aep amplitudes analgesic analog auditory categorical deteriorated enlarged errors evoked investigates mood morphine n1 neurophysiological oddball p2 pain perceptual potentials rated ratings reflected scales sedation stressor subjective vas vigilance
Tagcloud (Difference) ?		augmentation avenue confounded constitute conversely cre detrimental dissociation functionally hypothalamic hypothalamus isolating locomotor melanocortin neuroanatomically neurochemically neuron obesity opiomelanocortin pomc pomcneo reactivatable recombinase restrict severely subpopulations therapeutically thirds utilized	aep amplitudes analgesic analog auditory categorical deteriorated enlarged errors evoked investigates mood morphine n1 neurophysiological oddball p2 pain perceptual potentials rated ratings reflected scales sedation stressor subjective vas vigilance
Tagcloud (Intersection) ?