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LEPR and LEP
Number of citations of the paper that reports this interaction (PubMedID
8608603
)
0
Data Source:
HPRD
(in vivo)
LEPR
LEP
Description
leptin receptor
leptin
Image
GO Annotations
Cellular Component
Extracellular Region
Plasma Membrane
External Side Of Plasma Membrane
Membrane
Basolateral Plasma Membrane
Receptor Complex
Extracellular Region
Extracellular Space
Cytoplasm
Cytosol
Molecular Function
Transmembrane Signaling Receptor Activity
Cytokine Receptor Activity
Protein Binding
Peptide Hormone Binding
Cytokine Binding
Leptin Receptor Activity
Signaling Receptor Activity
Identical Protein Binding
DNA Binding
Signaling Receptor Binding
Hormone Activity
Protein Binding
Peptide Hormone Receptor Binding
Leptin Receptor Binding
Biological Process
Angiogenesis
Glycogen Metabolic Process
Gluconeogenesis
Energy Reserve Metabolic Process
Phagocytosis
Cell Surface Receptor Signaling Pathway
Multicellular Organism Development
Cholesterol Metabolic Process
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Autophagy
Glial Cell Proliferation
Cytokine-mediated Signaling Pathway
Sexual Reproduction
T Cell Differentiation
Leptin-mediated Signaling Pathway
Glucose Homeostasis
Response To Leptin
Negative Regulation Of Gluconeogenesis
Regulation Of Bone Remodeling
System Development
Regulation Of Transport
Regulation Of Feeding Behavior
Energy Homeostasis
Cell Surface Receptor Signaling Pathway Via STAT
Bone Growth
Positive Regulation Of Cold-induced Thermogenesis
Transport Across Blood-brain Barrier
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Ovulation From Ovarian Follicle
Response To Hypoxia
Positive Regulation Of Cytokine Production
Placenta Development
Regulation Of Endothelial Cell Proliferation
Response To Dietary Excess
Cardiac Muscle Hypertrophy
Glucose Metabolic Process
Regulation Of Gluconeogenesis
Energy Reserve Metabolic Process
Glycerol Biosynthetic Process
Lipid Metabolic Process
Fatty Acid Beta-oxidation
Phagocytosis
Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Female Pregnancy
Response To Nutrient
Circadian Rhythm
Cholesterol Metabolic Process
Bile Acid Metabolic Process
Regulation Of Blood Pressure
Positive Regulation Of Cell Population Proliferation
Determination Of Adult Lifespan
Adult Feeding Behavior
Fatty Acid Catabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Autophagy
Negative Regulation Of Lipid Storage
Response To Activity
Regulation Of Metabolic Process
Sexual Reproduction
Central Nervous System Neuron Development
Insulin Secretion
T Cell Differentiation
Regulation Of Intestinal Cholesterol Absorption
Response To Nutrient Levels
Positive Regulation Of TOR Signaling
Negative Regulation Of Appetite
Prostaglandin Secretion
Response To Estradiol
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Natural Killer Cell Activation
Regulation Of Natural Killer Cell Proliferation
Response To Insulin
Cellular Response To Insulin Stimulus
Response To Vitamin E
Leptin-mediated Signaling Pathway
Positive Regulation Of Luteinizing Hormone Secretion
Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Intracellular Signal Transduction
Bone Mineralization Involved In Bone Maturation
Aorta Development
Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Protein Import Into Nucleus
Hormone Metabolic Process
Glucose Homeostasis
Eating Behavior
Negative Regulation Of Apoptotic Process
Positive Regulation Of Monoatomic Ion Transport
Positive Regulation Of MAPK Cascade
Cellular Response To Leptin Stimulus
Response To Ethanol
Regulation Of Fat Cell Differentiation
Regulation Of Angiogenesis
Negative Regulation Of Vasoconstriction
Negative Regulation Of D-glucose Import
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Bone Remodeling
Positive Regulation Of Follicle-stimulating Hormone Secretion
Regulation Of Lipid Biosynthetic Process
Positive Regulation Of Developmental Growth
Regulation Of Insulin Secretion
Regulation Of Steroid Biosynthetic Process
Intestinal Absorption
Leukocyte Tethering Or Rolling
Regulation Of Nitric-oxide Synthase Activity
Negative Regulation Of Transport
Elastin Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Regulation Of Lipoprotein Lipid Oxidation
Adipose Tissue Development
Negative Regulation Of Cartilage Development
Negative Regulation Of Glucagon Secretion
Cellular Response To L-ascorbic Acid
Cellular Response To Retinoic Acid
Regulation Of Brown Fat Cell Differentiation
Energy Homeostasis
Cell Surface Receptor Signaling Pathway Via STAT
Bone Growth
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Protein Localization To Nucleus
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Fat Cell Apoptotic Process
Activation Of Protein Kinase C Activity
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Glutamine Transport
Positive Regulation Of Hepatic Stellate Cell Activation
Pathways
Signaling by Leptin
Transcriptional regulation of white adipocyte differentiation
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and deacylation of Ghrelin
Drugs
Leptin
Metreleptin
Diseases
GWAS
Adult body size (
32376654
)
Age at voice drop (
27182965
)
Alanine aminotransferase levels (
34315874
33547301
)
Apolipoprotein A1 levels (
32203549
)
Aspartate aminotransferase levels (
34315874
33547301
)
Blood protein levels (
30072576
)
BMI at 1 year old (
31575865
)
BMI at 1.5 years old (
31575865
)
BMI at 3 months old (
31575865
)
BMI at 6 months old (
31575865
)
BMI at 8 months old (
31575865
)
BMI at adiposity peak (
31840077
)
Body size at age 10 (
32376654
)
C-reactive protein (
23844046
18439548
22939635
19567438
)
C-reactive protein levels (
33339817
21300955
29878111
30388399
)
C-reactive protein levels or triglyceride levels (pleiotropy) (
27286809
)
Eosinophil percentage of white cells (
32888494
)
Fasting plasma glucose (childhood) (
25223902
)
Fibrinogen (
23969696
)
Fibrinogen levels (
28107422
26561523
)
Granulocyte count (
27863252
)
HDL cholesterol levels (
32203549
)
Hemoglobin (
32888494
)
Hip circumference (
28552196
)
Iron status biomarkers (iron levels) (
33536631
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Lymphocyte percentage of white cells (
27863252
32888494
)
Mean corpuscular hemoglobin (
27863252
32888494
)
Mean corpuscular volume (
27863252
32888494
)
Mean spheric corpuscular volume (
32888494
)
Menarche (age at onset) (
25231870
)
Metabolic traits (
19060910
)
Molybdenum levels (
26025379
)
Monocyte percentage of white cells (
32888494
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
27863252
)
Neutrophil percentage of white cells (
32888494
)
Nonalcoholic steatohepatitis (
32298765
)
Obesity (early onset extreme) (
23563609
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Serum alkaline phosphatase levels (
33547301
)
Soluble leptin receptor levels (
20167575
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
White blood cell count (
32888494
27863252
)
BMI at 1.5 years old (
31575865
)
BMI at 8 months old (
31575865
)
Body size at age 10 (
32376654
)
circulating leptin levels (
26833098
32917775
)
circulating leptin levels adjusted for BMI (
26833098
32917775
)
High density lipoprotein cholesterol levels (
29403010
)
Interleukin-6 levels in non-alcoholic fatty liver disease x mastiha supplementation interaction (
34025683
)
Type 2 diabetes (
23945395
26818947
32499647
)
Interacting Genes
17 interacting genes:
APOD
CLU
CSNK2B
DGKZ
JAK2
LEP
PIN1
PTPN11
RNF41
SNX1
SNX2
SNX4
SNX6
SOCS3
STAT3
USP7
XRN1
12 interacting genes:
A2M
CLU
CRP
GHRL
HK3
HSF2BP
LEPR
PRKAA2
S100A6
S100P
SIGLEC6
UCN
Entrez ID
3953
3952
HPRD ID
03001
01249
Ensembl ID
ENSG00000116678
ENSG00000174697
Uniprot IDs
P48357
Q4G138
A4D0Y8
P41159
PDB IDs
3V6O
6E2P
7Z3Q
8AVE
8AVF
8AVO
8X80
8X81
8X85
1AX8
7Z3Q
8AVE
8AVF
8AVO
8K6Z
8X80
8X81
8X85
Enriched GO Terms of Interacting Partners
?
Leptin Receptor Binding
Retromer, Tubulation Complex
Insulin Receptor Binding
Negative Regulation Of Cell Communication
Regulation Of Protein Metabolic Process
Negative Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Signaling
Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production
Positive Regulation Of Tumor Necrosis Factor Production
Peptide Hormone Receptor Binding
Transferrin Receptor Binding
Regulation Of Signal Transduction
Cell Surface Receptor Signaling Pathway Via JAK-STAT
Interleukin-6-mediated Signaling Pathway
Positive Regulation Of Catabolic Process
Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Metabolic Process
Regulation Of Lipoprotein Lipid Oxidation
Negative Regulation Of Protein Metabolic Process
Cell Surface Receptor Signaling Pathway Via STAT
Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation
Regulation Of Protein Catabolic Process
Regulation Of Autophagy
Retromer Complex
Negative Regulation Of Catabolic Process
Regulation Of Cytokine Production Involved In Inflammatory Response
Cytosol
Cytokine-mediated Signaling Pathway
Negative Regulation Of Signal Transduction
Symbiont-mediated Disruption Of Host Cell PML Body
Positive Regulation Of Skeletal Muscle Cell Proliferation
Negative Regulation Of Autophagy
Phosphatidylinositol Binding
Negative Regulation Of Macromolecule Metabolic Process
Protein-containing Complex
Regulation Of Hormone Secretion
Regulation Of Intracellular Transport
Epidermal Growth Factor Receptor Binding
Regulation Of Nucleocytoplasmic Transport
Regulation Of Transport
Regulation Of Immune System Process
Regulation Of Defense Response
Regulation Of Intracellular Protein Transport
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Hormone Secretion
Establishment Of Protein Localization
Negative Regulation Of 3'-UTR-mediated MRNA Stabilization
Interleukin-23-mediated Signaling Pathway
Regulation Of Protein Localization To Nucleus
Extracellular Region
Regulation Of Feeding Behavior
Positive Regulation Of Corticotropin Secretion
Regulation Of Corticotropin Secretion
Calcium-dependent Protein Binding
Regulation Of Behavior
Negative Regulation Of Complement Activation
Secretory Granule Lumen
Regulation Of Response To Food
Glucose Metabolic Process
Regulation Of Complement Activation
Regulation Of Appetite
Low-density Lipoprotein Particle Receptor Binding
Glial Cell Proliferation
Hexose Metabolic Process
Positive Regulation Of Behavior
Monosaccharide Metabolic Process
Regulation Of Response To Nutrient Levels
Carbohydrate Homeostasis
Glucose Homeostasis
Regulation Of Release Of Cytochrome C From Mitochondria
Regulation Of Humoral Immune Response
Perinuclear Endoplasmic Reticulum Lumen
Regulation Of Neuronal Signal Transduction
Leptin Receptor Activity
Response To Hormone
Positive Regulation Of Muscle Contraction
Ghrelin Receptor Binding
Cortisol Secretion
Positive Regulation Of Gastric Mucosal Blood Circulation
Protein Localization To Lysosome
Vascular Process In Circulatory System
Platelet Alpha Granule Lumen
Negative Regulation Of Complement Activation, Lectin Pathway
Positive Regulation Of Neurofibrillary Tangle Assembly
Circulatory System Process
Generation Of Precursor Metabolites And Energy
Energy Homeostasis
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Histone H2BS36 Kinase Activity
Negative Regulation Of Hormone Secretion
G Protein-coupled Receptor Binding
Histone Deacetylase Inhibitor Activity
Growth Hormone-releasing Hormone Activity
Negative Regulation Of Circadian Sleep/wake Cycle, REM Sleep
Positive Regulation Of Small Intestinal Transit
Positive Regulation Of Growth Rate
Feeding Behavior
Interleukin-8 Binding
Regulation Of Cytokine Production
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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