LEPR and CLU

Number of citations of the paper that reports this interaction (PMID 12824284)
3

Data Source:
HPRD (in vitro)

		LEPR	CLU
Gene Name		leptin receptor	clusterin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane Receptor Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Matrix Platelet Alpha Granule Lumen Mitochondrial Membrane Spherical High-density Lipoprotein Particle Chromaffin Granule Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle Neurofibrillary Tangle Apical Dendrite
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Identical Protein Binding	Protein Binding ATPase Activity Ubiquitin Protein Ligase Binding Misfolded Protein Binding
	Biological Process	Energy Reserve Metabolic Process Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Cholesterol Metabolic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Gluconeogenesis Negative Regulation Of Hydrolase Activity	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Platelet Degranulation Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Blood Coagulation Response To Virus Protein Import Platelet Activation Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Chaperone-mediated Protein Folding Microglial Cell Proliferation Intrinsic Apoptotic Signaling Pathway Regulation Of Beta-amyloid Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Beta-amyloid Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		C-reactive protein ( 19567438 18439548 21300955 22939635) Metabolic traits ( 19060910) Obesity (early onset extreme) ( 23563609) Soluble leptin receptor levels ( 20167575)	Alzheimer's disease ( 19734902 19734903 21627779) Alzheimer's disease (late onset) ( 21460841) Panic disorder ( 19165232)
Protein-Protein Interactions		16 interactors: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 XRN1	44 interactors: APP BAG6 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 ELN FOS GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN LEP LEPR LIG4 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 PAXIP1 POLR1C PON1 PRNP RBBP8 RPL23 SYVN1 TGFBR1 TGFBR2 TNIK TSC22D4 TTR VHL VLDLR XRCC6 ZWINT
Entrez ID		3953	1191
HPRD ID		03001	01706
Ensembl ID		ENSG00000116678	ENSG00000120885
Uniprot IDs		P48357 Q4G138	P10909
PDB IDs		3V6O
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Phosphorylation JAK-STAT Cascade Cellular Response To Cytokine Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Response To Cytokine Regulation Of Protein Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Negative Regulation Of Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Locomotion Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Hormone Secretion Regulation Of Immune System Process Protein Transport Cellular Response To Hormone Stimulus Establishment Of Protein Localization Regulation Of Cell Motility Response To Growth Hormone Regulation Of Locomotion Regulation Of Cellular Component Movement Lamellipodium Morphogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Regulation Of Kinase Activity Negative Regulation Of Cell Migration Endosomal Transport Response To Peptide Hormone Retrograde Transport, Endosome To Golgi Vesicle Organization Regulation Of Cell Activation Regulation Of Nucleocytoplasmic Transport Protein Localization Response To Peptide Positive Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Tyrosine Phosphorylation Of STAT Protein Establishment Of Localization In Cell Positive Regulation Of Protein Modification Process	Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Response To Radiation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Developmental Process Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Cell Differentiation Defense Response Multicellular Organismal Development Cytolysis Cellular Response To Stimulus Innate Immune Response Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Central Nervous System Development Positive Regulation Of Proteolysis Complement Activation, Alternative Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Cell Development Response To External Stimulus Positive Regulation Of Cell Differentiation Regulation Of Phosphorylation Generation Of Neurons Alcohol Metabolic Process Positive Regulation Of Metabolic Process System Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Phosphorylation Neurogenesis Steroid Metabolic Process Regulation Of Apoptotic Process Apoptotic Process Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation
Tagcloud ?		augmentation avenue confounded constitute conversely cre detrimental dissociation functionally hypothalamic hypothalamus isolating locomotor melanocortin neuroanatomically neurochemically neuron obesity opiomelanocortin pomc pomcneo reactivatable recombinase restrict severely subpopulations therapeutically thirds utilized	allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
Tagcloud (Difference) ?		augmentation avenue confounded constitute conversely cre detrimental dissociation functionally hypothalamic hypothalamus isolating locomotor melanocortin neuroanatomically neurochemically neuron obesity opiomelanocortin pomc pomcneo reactivatable recombinase restrict severely subpopulations therapeutically thirds utilized	allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss
Tagcloud (Intersection) ?