LEPR and CLU

Number of citations of the paper that reports this interaction (PubMedID 12824284)
0

Data Source:
HPRD (in vitro)

		LEPR	CLU
Description		leptin receptor	clusterin
Image
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Receptor Complex	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane Platelet Alpha Granule Lumen Cytoplasmic Vesicle Mitochondrial Membrane Protein-containing Complex Spherical High-density Lipoprotein Particle Chromaffin Granule Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle Neurofibrillary Tangle Apical Dendrite Perinuclear Endoplasmic Reticulum Lumen
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Leptin Receptor Activity Signaling Receptor Activity Identical Protein Binding	Amyloid-beta Binding Signaling Receptor Binding Protein Binding ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein Heterodimerization Activity Receptor Ligand Activity Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding Protein Sequestering Activity Protein Carrier Chaperone
	Biological Process	Angiogenesis Glycogen Metabolic Process Gluconeogenesis Energy Reserve Metabolic Process Phagocytosis Cell Surface Receptor Signaling Pathway Multicellular Organism Development Cholesterol Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Autophagy Glial Cell Proliferation Cytokine-mediated Signaling Pathway Sexual Reproduction T Cell Differentiation Leptin-mediated Signaling Pathway Glucose Homeostasis Response To Leptin Negative Regulation Of Gluconeogenesis Regulation Of Bone Remodeling System Development Regulation Of Transport Regulation Of Feeding Behavior Energy Homeostasis Cell Surface Receptor Signaling Pathway Via STAT Bone Growth Positive Regulation Of Cold-induced Thermogenesis Transport Across Blood-brain Barrier	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Negative Regulation Of Activation Of Membrane Attack Complex Immune System Process Immune Complex Clearance Protein Folding Lipid Metabolic Process Apoptotic Process Complement Activation Complement Activation, Classical Pathway Response To Virus Positive Regulation Of Gene Expression Protein Import Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Complement Activation Positive Regulation Of Receptor-mediated Endocytosis Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Microglial Cell Proliferation Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Negative Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Amyloid-beta Clearance Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Amyloid-beta Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade
Drugs		Leptin Metreleptin	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Adult body size ( 32376654) Age at voice drop ( 27182965) Alanine aminotransferase levels ( 34315874 33547301) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 34315874 33547301) Blood protein levels ( 30072576) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) BMI at 3 months old ( 31575865) BMI at 6 months old ( 31575865) BMI at 8 months old ( 31575865) BMI at adiposity peak ( 31840077) Body size at age 10 ( 32376654) C-reactive protein ( 23844046 18439548 22939635 19567438) C-reactive protein levels ( 33339817 21300955 29878111 30388399) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Eosinophil percentage of white cells ( 32888494) Fasting plasma glucose (childhood) ( 25223902) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Hip circumference ( 28552196) Iron status biomarkers (iron levels) ( 33536631) Liver enzyme levels (alanine transaminase) ( 33972514) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Metabolic traits ( 19060910) Molybdenum levels ( 26025379) Monocyte percentage of white cells ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Nonalcoholic steatohepatitis ( 32298765) Obesity (early onset extreme) ( 23563609) Platelet count ( 32888494) Plateletcrit ( 32888494) Serum alkaline phosphatase levels ( 33547301) Soluble leptin receptor levels ( 20167575) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494 27863252)	Alzheimer's disease ( 19734902 19734903 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256 28714976) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Family history of Alzheimer's disease ( 30617256) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Panic disorder ( 19165232) Refractive error ( 32231278) Schizophrenia ( 29483656 25056061) Smoking behaviour (cigarettes smoked per day) ( 31089300) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		17 interacting genes: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 USP7 XRN1	62 interacting genes: APP BAG6 BTG3 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 DLG4 DSCAM DSCR9 DYRK1A ELN EPPIN ETS2 FOS GRB2 HSPA13 HSPD1 HUNK IL24 KATNA1 KEAP1 KLF11 KNSTRN LCOR LEP LEPR LIG4 LRP1 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 MSRB1 PAXIP1 PLXNA4 POLR1C PON1 PRNP RBBP8 RPL23 RSPH1 SHANK3 SRPK2 SYVN1 TGFBR1 TGFBR2 TNIK TREM2 TSC22D4 TTR UBC VHL VLDLR XRCC6 ZWINT
Entrez ID		3953	1191
HPRD ID		03001	01706
Ensembl ID		ENSG00000116678	ENSG00000120885
Uniprot IDs		P48357 Q4G138	P10909
PDB IDs		3V6O 6E2P 7Z3Q 8AVE 8AVF 8AVO 8X80 8X81 8X85	7ZET 7ZEU
Enriched GO Terms of Interacting Partners?		Leptin Receptor Binding Retromer, Tubulation Complex Insulin Receptor Binding Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Peptide Hormone Receptor Binding Transferrin Receptor Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Positive Regulation Of Catabolic Process Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Metabolic Process Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Regulation Of Protein Catabolic Process Regulation Of Autophagy Retromer Complex Negative Regulation Of Catabolic Process Regulation Of Cytokine Production Involved In Inflammatory Response Cytosol Cytokine-mediated Signaling Pathway Negative Regulation Of Signal Transduction Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Skeletal Muscle Cell Proliferation Negative Regulation Of Autophagy Phosphatidylinositol Binding Negative Regulation Of Macromolecule Metabolic Process Protein-containing Complex Regulation Of Hormone Secretion Regulation Of Intracellular Transport Epidermal Growth Factor Receptor Binding Regulation Of Nucleocytoplasmic Transport Regulation Of Transport Regulation Of Immune System Process Regulation Of Defense Response Regulation Of Intracellular Protein Transport Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Hormone Secretion Establishment Of Protein Localization Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Regulation Of Protein Localization To Nucleus	Apolipoprotein Binding Low-density Lipoprotein Particle Receptor Activity Cell Projection Morphogenesis Neuron Projection Organization Neuron Projection Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Receptor Complex Cell Activation Positive Regulation Of Protein Catabolic Process Membrane Attack Complex Other Organism Cell Membrane Regulation Of Proteolysis Cargo Receptor Activity Response To Stress Regulation Of Immune Response Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Signal Transduction Dendritic Spine Organization System Development Endocytosis Clathrin-coated Pit Memory Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Development High-density Lipoprotein Particle Binding Anatomical Structure Morphogenesis Protein-containing Complex Binding Regulation Of Cell Projection Organization Intracellular Signal Transduction Complement Activation, GZMK Pathway Nervous System Development Cellular Response To Growth Factor Stimulus Reelin Receptor Activity Positive Regulation Of Proteolysis Transmembrane Transporter Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Surface Receptor Signaling Pathway Cell Projection Organization Positive Regulation Of Cell Activation Immune Effector Process Immune System Process Postsynapse Organization Regulation Of Immune System Process Regulation Of Developmental Process Complement Activation, Alternative Pathway Terpenoid Metabolic Process Cellular Response To Oxygen-containing Compound Cognition
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