LEPR and APOD

Number of citations of the paper that reports this interaction (PMID 11344130)
6

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		LEPR	APOD
Gene Name		leptin receptor	apolipoprotein D
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane Receptor Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Cytosolic Ribosome Dendrite Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Protein Binding Identical Protein Binding	Lipid Transporter Activity Protein Binding Cholesterol Binding
	Biological Process	Energy Reserve Metabolic Process Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Cholesterol Metabolic Process Cytokine-mediated Signaling Pathway Negative Regulation Of Gluconeogenesis Negative Regulation Of Hydrolase Activity	Response To Reactive Oxygen Species Angiogenesis Glucose Metabolic Process Lipid Metabolic Process Lipid Transport Brain Development Aging Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Peripheral Nervous System Axon Regeneration Tissue Regeneration Negative Regulation Of Protein Import Into Nucleus Response To Drug Negative Regulation Of Smooth Muscle Cell Proliferation Response To Axon Injury Negative Regulation Of Focal Adhesion Assembly Negative Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Monocyte Chemotactic Protein-1 Production Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of T Cell Migration
Pathways			Transport of vitamins, nucleosides, and related molecules SLC-mediated transmembrane transport Transport of fatty acids Orphan transporters
Drugs
Diseases
GWAS		C-reactive protein ( 19567438 18439548 21300955 22939635) Metabolic traits ( 19060910) Obesity (early onset extreme) ( 23563609) Soluble leptin receptor levels ( 20167575)
Protein-Protein Interactions		16 interactors: APOD CLU CSNK2B DGKZ JAK2 LEP PIN1 PTPN11 RNF41 SNX1 SNX2 SNX4 SNX6 SOCS3 STAT3 XRN1	5 interactors: APOA2 LEPR POLR2M SHBG VAPA
Entrez ID		3953	347
HPRD ID		03001	00134
Ensembl ID		ENSG00000116678	ENSG00000189058
Uniprot IDs		P48357 Q4G138	P05090
PDB IDs		3V6O	2APD 2HZQ 2HZR
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Regulation Of Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Phosphorylation JAK-STAT Cascade Cellular Response To Cytokine Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Response To Cytokine Regulation Of Protein Metabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Cellular Component Movement Negative Regulation Of Signaling JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Lipoprotein Lipid Oxidation Negative Regulation Of Locomotion Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Positive Regulation Of Hormone Secretion Regulation Of Immune System Process Protein Transport Cellular Response To Hormone Stimulus Establishment Of Protein Localization Regulation Of Cell Motility Response To Growth Hormone Regulation Of Locomotion Regulation Of Cellular Component Movement Lamellipodium Morphogenesis Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Transport Regulation Of Kinase Activity Negative Regulation Of Cell Migration Endosomal Transport Response To Peptide Hormone Retrograde Transport, Endosome To Golgi Vesicle Organization Regulation Of Cell Activation Regulation Of Nucleocytoplasmic Transport Protein Localization Response To Peptide Positive Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Tyrosine Phosphorylation Of STAT Protein Establishment Of Localization In Cell Positive Regulation Of Protein Modification Process	Negative Regulation Of Growth Hormone Receptor Signaling Pathway Maintenance Of ER Location Primary Spermatocyte Growth Negative Regulation Of Cholesterol Transporter Activity Cholesterol Metabolic Process Sterol Metabolic Process Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Release From Host Cell Regulation Of Cholesterol Transporter Activity Negative Regulation Of Cholesterol Import Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Endoplasmic Reticulum Localization Regulation Of Cholesterol Import Regulation Of Growth Hormone Receptor Signaling Pathway Positive Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Process Diacylglycerol Catabolic Process Steroid Metabolic Process High-density Lipoprotein Particle Clearance Regulation Of Intestinal Cholesterol Absorption Protein Oxidation Lipid Metabolic Process Positive Regulation Of Viral Release From Host Cell Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Interleukin-8 Biosynthetic Process High-density Lipoprotein Particle Assembly Negative Regulation Of Protein Localization To Cell Surface Positive Regulation Of Cholesterol Esterification Peptidyl-methionine Modification Alcohol Metabolic Process Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Triglyceride-rich Lipoprotein Particle Remodeling Negative Regulation Of Gluconeogenesis Phospholipid Efflux Regulation Of Interleukin-8 Biosynthetic Process Low-density Lipoprotein Particle Remodeling Negative Regulation Of Hydrolase Activity Regulation Of Cytokine Secretion Involved In Immune Response High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Negative Regulation Of Lipase Activity Reverse Cholesterol Transport Diacylglycerol Metabolic Process Regulation Of Protein Localization To Cell Surface Positive Regulation Of Viral Genome Replication COPII-coated Vesicle Budding Regulation Of Viral Release From Host Cell Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Lipid Transport
Tagcloud ?		augmentation avenue confounded constitute conversely cre detrimental dissociation functionally hypothalamic hypothalamus isolating locomotor melanocortin neuroanatomically neurochemically neuron obesity opiomelanocortin pomc pomcneo reactivatable recombinase restrict severely subpopulations therapeutically thirds utilized	a4 antitrypsin apoa apoc apof apoh apoj apol apolipoproteins apom atherogenic carry chd convincingly delipidation dense differs fibrinogen ldl lysosome originate paraoxonase prenylcysteine proteome sdldl strengthens subfractions transthyretin vldl
Tagcloud (Difference) ?		augmentation avenue confounded constitute conversely cre detrimental dissociation functionally hypothalamic hypothalamus isolating locomotor melanocortin neuroanatomically neurochemically neuron obesity opiomelanocortin pomc pomcneo reactivatable recombinase restrict severely subpopulations therapeutically thirds utilized	a4 antitrypsin apoa apoc apof apoh apoj apol apolipoproteins apom atherogenic carry chd convincingly delipidation dense differs fibrinogen ldl lysosome originate paraoxonase prenylcysteine proteome sdldl strengthens subfractions transthyretin vldl
Tagcloud (Intersection) ?