RALB and PLCD1

Number of citations of the paper that reports this interaction (PubMedID 15817490)
0

Data Source:
HPRD (two hybrid, in vitro)

		RALB	PLCD1
Description		RAS like proto-oncogene B	phospholipase C delta 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Midbody Extracellular Exosome	Cytoplasm Plasma Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Ubiquitin Protein Ligase Binding ATPase Binding	Phosphatidylserine Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity GTPase Activating Protein Binding Anion Binding Metal Ion Binding Phosphatidic Acid Binding Phosphatidylinositol Phospholipase C Activity Phosphatidylinositol Phosphate Binding
	Biological Process	Regulation Of Exocyst Assembly Apoptotic Process Signal Transduction Ras Protein Signal Transduction Receptor Internalization Positive Regulation Of Innate Immune Response Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cell Division Regulation Of Exocyst Localization Positive Regulation Of Autophagosome Assembly	Lipid Metabolic Process Phospholipid Metabolic Process Signal Transduction Lipid Catabolic Process Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phospholipase C/protein Kinase C Signal Transduction
Pathways		p38MAPK events	Synthesis of IP3 and IP4 in the cytosol
Drugs			1D-myo-inositol 1,4,5-trisphosphate Inositol 2,4,5-trisphosphate
Diseases
GWAS		Breast size ( 27182965) Intraocular pressure ( 29617998) Mean platelet volume ( 27863252 32888494) Metabolite levels ( 23823483) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		7 interacting genes: CALM1 INCA1 PLCD1 RALBP1 REPS1 REPS2 RGL4	10 interacting genes: APP CALM1 GAP43 HGS KPNB1 NTAQ1 PAXIP1 RALA RALB TGM2
Entrez ID		5899	5333
HPRD ID		01550	09073
Ensembl ID		ENSG00000144118	ENSG00000187091
Uniprot IDs		P11234	A0A384MR47 A8K8F9 P51178
PDB IDs		2KE5 2KWI 6ZQT 6ZRN
Enriched GO Terms of Interacting Partners?		Endocytosis Intracellular Signaling Cassette Import Into Cell Calcium Ion Binding Signal Transduction Intracellular Signal Transduction Plasma Membrane C-X-C Motif Chemokine 12 Receptor Activity Doxorubicin Transport Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway Vesicle-mediated Transport Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Calcium-mediated Signaling Transporter Inhibitor Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Autophagosome Membrane Docking Spindle Pole Phosphatidylinositol Phospholipase C Activity Anion Binding Phospholipase C/protein Kinase C Signal Transduction CXCL12-activated CXCR4 Signaling Pathway Myosin Light Chain Binding Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway C-X-C Chemokine Receptor CXCR4 Signaling Pathway Negative Regulation Of Voltage-gated Calcium Channel Activity Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway C-X-C Chemokine Receptor Activity ABC-type Glutathione S-conjugate Transporter Activity Protein-macromolecule Adaptor Activity Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity	Endocytosis Import Into Cell Axon Choice Point Recognition Receptor Internalization Vesicle-mediated Transport Response To Auditory Stimulus Cellular Response To Catecholamine Stimulus Response To Catecholamine Positive Regulation Of Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Receptor-mediated Endocytosis Positive Regulation Of ERBB Signaling Pathway Regulation Of Vesicle-mediated Transport Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Amylin Binding Positive Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Neuron Recognition Regulation Of Filopodium Assembly Regulation Of Exocyst Assembly Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Protein-N-terminal Glutamine Amidohydrolase Activity Synaptic Membrane Acetylcholine Receptor Activator Activity Regulation Of Signal Transduction G Protein-coupled Receptor Signaling Pathway Lipoprotein Particle Regulation Of Receptor Internalization Positive Regulation Of Protein Import Signal Transduction Extracellular Exosome Regulation Of Endocytosis Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Establishment Of Protein Localization To Organelle ATPase Binding GDP Binding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Edg-2 Lysophosphatidic Acid Receptor Binding G Protein Activity
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