ATF4 and SNAP29

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ATF4	SNAP29
Gene Name		activating transcription factor 4	synaptosomal-associated protein, 29kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Dendrite Membrane Nuclear Periphery Neuron Projection Lewy Body Core ATF1-ATF4 Transcription Factor Complex	Cytoplasm Centrosome Plasma Membrane Cell Junction SNARE Complex Neuron Projection Synapse
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	SNAP Receptor Activity Syntaxin Binding
	Biological Process	Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cellular Amino Acid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gamma-aminobutyric Acid Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Endoplasmic Reticulum Unfolded Protein Response Circadian Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Response To Glucose Starvation Positive Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Autophagic Vacuole Fusion Exocytosis Vesicle Targeting Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Membrane Fusion
Pathways		ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		65 interactors: APH1A APP ASB7 ATF2 ATF3 BATF BATF2 BATF3 BFSP2 BTRC CCDC106 CEBPA CEBPB CEBPE CEBPG CKAP4 CREB3 CREBZF DAPK3 DDIT3 DISC1 EGLN3 FOS FOSL1 GABBR2 GCC1 GOLGA1 GOLGA8EP GOLGA8F GPS2 GTF2A1L GTF2B GTF2F2 HAUS7 HK3 JUN JUNB KAT2B LDOC1 LMNB1 MAF MAFB MAP2K7 MDM2 MPZL2 NDC80 NEK6 NFE2 NFE2L1 NFE2L2 NFKBIA POLR2C PTCD3 REPS1 RPS6 SNAP29 SRA1 TBP TGM2 TREX2 TRIB3 TRIM24 TTR ZNF212 ZNF226	22 interactors: AP2A1 ATF4 CD7 EHD1 EHD3 FAM9B ITSN2 KIFC3 LURAP1 RASSF7 STX12 STX17 STX1A STX3 STX4 STX6 STX7 VAMP1 VAMP2 VAMP4 VAMP5 VAMP7
Entrez ID		468	9342
HPRD ID		06817	11968
Ensembl ID		ENSG00000128272	ENSG00000099940
Uniprot IDs		P18848 Q96AQ3	O95721
PDB IDs		1CI6
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Stress Myeloid Cell Differentiation Leukocyte Differentiation Cellular Metabolic Process Response To Stress Apoptotic Process Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Organ Development Myeloid Leukocyte Differentiation Defense Response Programmed Cell Death Immune System Process Response To Stimulus Cell Death Death Hemopoiesis Response To External Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Vesicle Fusion Organelle Fusion Membrane Fusion Vesicle Organization Vesicle-mediated Transport Membrane Organization Intracellular Protein Transport Establishment Of Localization In Cell Cellular Protein Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Cellular Localization Vesicle Docking SNARE Complex Assembly Membrane Docking Exocytosis Protein Localization Endomembrane System Organization Golgi Vesicle Transport Secretion By Cell Post-Golgi Vesicle-mediated Transport Organelle Organization Neurotransmitter Secretion Secretion Transport Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Neurotransmitter Levels Regulation Of Protein Localization To Plasma Membrane Synaptic Vesicle Exocytosis Regulation Of Protein Localization Neurotransmitter Transport Golgi Organization Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization To Plasma Membrane Endosomal Transport Golgi To Plasma Membrane Protein Transport Regulation Of Cellular Localization Eosinophil Degranulation Synaptic Vesicle Transport Positive Regulation Of Synaptic Transmission Golgi To Plasma Membrane Transport Calcium Ion-dependent Exocytosis Protein Localization To Plasma Membrane Regulation Of Exocytosis Long-term Synaptic Potentiation Golgi Ribbon Formation Protein Complex Assembly Positive Regulation Of Protein Localization To Cell Surface Positive Regulation Of Exocytosis
Tagcloud ?		activates anticancer attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3	92e accumulates architecture asparagine autophagic autophagosomes cednik dispensable distinctive dysgenesis highlighting hop hopscotch ichthyosis keratoderma localizes neuropathy npf nsf organelles palmoplantar phenylalanine routes snare stat92e synaptosomal trafficking uncharacterized unlikely
Tagcloud (Difference) ?		activates anticancer attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3	92e accumulates architecture asparagine autophagic autophagosomes cednik dispensable distinctive dysgenesis highlighting hop hopscotch ichthyosis keratoderma localizes neuropathy npf nsf organelles palmoplantar phenylalanine routes snare stat92e synaptosomal trafficking uncharacterized unlikely
Tagcloud (Intersection) ?