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ATF4 and REPS1
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
ATF4
REPS1
Gene Name
activating transcription factor 4
RALBP1 associated Eps domain containing 1
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Dendrite Membrane
Nuclear Periphery
Neuron Projection
Lewy Body Core
ATF1-ATF4 Transcription Factor Complex
Plasma Membrane
Coated Pit
Molecular Function
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Transcription Factor Binding Transcription Factor Activity
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
DNA Binding
Sequence-specific DNA Binding Transcription Factor Activity
Protein Binding
Protein C-terminus Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Calcium Ion Binding
Protein Binding
SH3 Domain Binding
Biological Process
Gluconeogenesis
Regulation Of Transcription, DNA-templated
Transcription From RNA Polymerase II Promoter
Cellular Amino Acid Metabolic Process
Activation Of Signaling Protein Activity Involved In Unfolded Protein Response
Gamma-aminobutyric Acid Signaling Pathway
Positive Regulation Vascular Endothelial Growth Factor Production
Endoplasmic Reticulum Unfolded Protein Response
Circadian Regulation Of Gene Expression
Response To Endoplasmic Reticulum Stress
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Cellular Response To Glucose Starvation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of Neuron Apoptotic Process
Cellular Protein Metabolic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase I Promoter
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Negative Regulation Of Oxidative Stress-induced Neuron Death
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Receptor-mediated Endocytosis
Pathways
ATF4 activates genes
PERK regulates gene expression
ATF6-alpha activates chaperones
ATF6-alpha activates chaperone genes
Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Protein-Protein Interactions
65 interactors:
APH1A
APP
ASB7
ATF2
ATF3
BATF
BATF2
BATF3
BFSP2
BTRC
CCDC106
CEBPA
CEBPB
CEBPE
CEBPG
CKAP4
CREB3
CREBZF
DAPK3
DDIT3
DISC1
EGLN3
FOS
FOSL1
GABBR2
GCC1
GOLGA1
GOLGA8EP
GOLGA8F
GPS2
GTF2A1L
GTF2B
GTF2F2
HAUS7
HK3
JUN
JUNB
KAT2B
LDOC1
LMNB1
MAF
MAFB
MAP2K7
MDM2
MPZL2
NDC80
NEK6
NFE2
NFE2L1
NFE2L2
NFKBIA
POLR2C
PTCD3
REPS1
RPS6
SNAP29
SRA1
TBP
TGM2
TREX2
TRIB3
TRIM24
TTR
ZNF212
ZNF226
13 interactors:
ATF4
CRK
GRB2
HSF1
ITSN2
PIN1
RAB11FIP2
RALA
RALB
RALBP1
REPS2
TRAPPC2L
WWC2
Entrez ID
468
85021
HPRD ID
06817
09687
Ensembl ID
ENSG00000128272
ENSG00000135597
Uniprot IDs
P18848
Q96AQ3
J3KP76
Q96D71
PDB IDs
1CI6
Enriched GO Terms of Interacting Partners
?
Transcription From RNA Polymerase II Promoter
RNA Biosynthetic Process
Transcription, DNA-templated
RNA Metabolic Process
Gene Expression
Regulation Of RNA Biosynthetic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of RNA Metabolic Process
Positive Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of Gene Expression
Cellular Macromolecule Biosynthetic Process
Regulation Of Nitrogen Compound Metabolic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Cellular Metabolic Process
Heterocycle Metabolic Process
Nucleobase-containing Compound Metabolic Process
Regulation Of Metabolic Process
Cellular Aromatic Compound Metabolic Process
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Biosynthetic Process
Nitrogen Compound Metabolic Process
Cellular Response To Stress
Myeloid Cell Differentiation
Leukocyte Differentiation
Cellular Metabolic Process
Response To Stress
Apoptotic Process
Cellular Response To Organic Substance
Negative Regulation Of Biosynthetic Process
Organ Development
Myeloid Leukocyte Differentiation
Defense Response
Programmed Cell Death
Immune System Process
Response To Stimulus
Cell Death
Death
Hemopoiesis
Response To External Stimulus
Negative Regulation Of Nucleic Acid-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Viral Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Rho GTPase Activity
Response To Organic Substance
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Cellular Response To Organic Substance
Regulation Of Rho Protein Signal Transduction
Vesicle-mediated Transport
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Catalytic Activity
Positive Regulation Of Metabolic Process
Regulation Of Ras GTPase Activity
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Transferase Activity
Ras Protein Signal Transduction
Cellular Response To Growth Factor Stimulus
Response To External Stimulus
Response To Growth Factor
Small GTPase Mediated Signal Transduction
Positive Regulation Of Rho GTPase Activity
Cellular Response To Stimulus
Regulation Of Ras Protein Signal Transduction
Regulation Of Phosphorylation
Positive Regulation Of Protein Phosphorylation
Regulation Of Small GTPase Mediated Signal Transduction
Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cellular Component Biogenesis
Regulation Of Exocyst Assembly
Signaling
Regulation Of GTPase Activity
Cell Communication
Regulation Of Phosphorus Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Phosphorylation
Regulation Of Exocyst Localization
Positive Regulation Of Autophagic Vacuole Assembly
Positive Regulation Of Vacuole Organization
Positive Regulation Of Protein Modification Process
Regulation Of Organelle Organization
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Ras GTPase Activity
Cytokinesis
Positive Regulation Of Hydrolase Activity
Embryonic Placenta Development
Positive Regulation Of Protein Kinase Activity
Regulation Of Signal Transduction
Regulation Of Protein Phosphorylation
Response To Stimulus
Positive Regulation Of Kinase Activity
Intracellular Signal Transduction
Tagcloud
?
activates
anticancer
attenuated
autophagy
cebpb
chip
ddit4
depletion
effectively
elusive
exo
genomic
greatly
largely
mitochondria
mtorc1
nude
pad
pan
perturbation
potentials
remain
resolution
responsive
sesn2
triple
unveiled
xenograft
yw3
Tagcloud (Difference)
?
activates
anticancer
attenuated
autophagy
cebpb
chip
ddit4
depletion
effectively
elusive
exo
genomic
greatly
largely
mitochondria
mtorc1
nude
pad
pan
perturbation
potentials
remain
resolution
responsive
sesn2
triple
unveiled
xenograft
yw3
Tagcloud (Intersection)
?