ATF4 and NFE2L2

Number of citations of the paper that reports this interaction (PubMedID 32911434)
54

Data Source:
BioGRID (fluorescent resonance energy transfer)
HPRD (in vivo, two hybrid, in vitro)

		ATF4	NFE2L2
Description		activating transcription factor 4	NFE2 like bZIP transcription factor 2
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Centrosome Cytosol Cytoskeleton Plasma Membrane Membrane Nuclear Speck Dendrite Membrane Protein-containing Complex Nuclear Periphery Neuron Projection RNA Polymerase II Transcription Regulator Complex Lewy Body Core ATF4-CREB1 Transcription Factor Complex ATF1-ATF4 Transcription Factor Complex CHOP-ATF4 Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Plasma Membrane Mediator Complex Protein-DNA Complex Ciliary Basal Body RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding Identical Protein Binding Leucine Zipper Domain Binding Sequence-specific DNA Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding General Transcription Initiation Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Molecular Condensate Scaffold Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Intracellular Calcium Ion Homeostasis Gamma-aminobutyric Acid Signaling Pathway Circadian Rhythm Response To Toxic Substance Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Neuron Differentiation Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Response To Nutrient Levels Negative Regulation Of Translational Initiation In Response To Stress Circadian Regulation Of Gene Expression Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To UV Response To Endoplasmic Reticulum Stress Embryonic Hemopoiesis PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation MRNA Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Rhythmic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Biomineral Tissue Development Lens Fiber Cell Morphogenesis L-asparagine Metabolic Process Cellular Response To Hypoxia Mitochondrial Respirasome Assembly Negative Regulation Of Cold-induced Thermogenesis Integrated Stress Response Signaling HRI-mediated Signaling GDF15-GFRAL Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Cellular Response To Leucine Starvation Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Sodium-dependent Phosphate Transport	Response To Ischemia Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Inflammatory Response Response To Oxidative Stress Response To Xenobiotic Stimulus Gene Expression Proteasomal Ubiquitin-independent Protein Catabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Blood Coagulation Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Innate Immune Response Cell Redox Homeostasis Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Aflatoxin Catabolic Process Positive Regulation Of D-glucose Import Cellular Response To Methionine Response To Caloric Restriction Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Xenobiotic Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Reactive Oxygen Species Metabolic Process Negative Regulation Of Ferroptosis Integrated Stress Response Signaling Negative Regulation Of Cellular Response To Hypoxia Regulation Of Cellular Response To Oxidative Stress Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Glutathione Biosynthetic Process Positive Regulation Of ERAD Pathway Cellular Response To Angiotensin Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Removal Of Superoxide Radicals Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress ATF4 activates genes in response to endoplasmic reticulum stress PERK regulates gene expression ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulating ER-stress associated genes	Neddylation Potential therapeutics for SARS Regulation of HMOX1 expression and activity Heme signaling KEAP1-NFE2L2 pathway KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 NFE2L2 regulating TCA cycle genes NFE2L2 regulating inflammation associated genes NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulates pentose phosphate pathway genes NFE2L2 regulating tumorigenic genes NFE2L2 regulating MDR associated enzymes NFE2L2 regulating ER-stress associated genes Regulation of NFE2L2 gene expression Regulation of NFE2L2 gene expression Regulation of PD-L1(CD274) transcription
Drugs		Pseudoephedrine
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Inflammatory bowel disease ( 23128233) Mean corpuscular volume ( 32888494)	A body shape index ( 34021172) Estimated glomerular filtration rate ( 30604766 31152163 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) HDL cholesterol levels ( 32203549) Refractive error ( 32231278)
Interacting Genes		75 interacting genes: AP1M1 APH1A APP ASB7 ATF2 ATF3 BATF BATF2 BATF3 BFSP2 BTRC CCDC106 CEBPA CEBPB CEBPE CEBPG CEP83 CKAP4 CREB3 CREBBP CREBZF DAPK3 DDIT3 DISC1 DNMT3L EGLN3 EP300 FOS FOSL1 GABBR2 GCC1 GOLGA1 GOLGA8EP GOLGA8F GPS2 GTF2A1L GTF2B GTF2F2 HAUS7 HK3 JDP2 JUN JUNB KAT2B LDOC1 LMNB1 MAF MAFB MAP2K7 MDM2 MPZL2 NAP1L5 NDC80 NEK6 NFE2 NFE2L1 NFE2L2 NFKBIA NLGN3 POLR2C PTCD3 REPS1 RPS6 SAPCD2 SNAP29 SRA1 TARS3 TBP TGM2 TREX2 TRIB3 TRIM24 TTR ZNF212 ZNF226	85 interacting genes: APEX1 ARFIP2 ARPC2 ATF3 ATF4 ATM ATR BPTF BRPF1 BRPF3 BTRC CASP1 CASP3 CDH1 CEBPG CERS2 CFAP299 CHD6 CLIC6 COPS7A CREB3 CREBBP CREBL2 CREBZF DDIT3 EIF2AK3 EIF3J ELF1 ELF3 ELF4 ELF5 ELK1 ETV1 ETV4 ETV6 FBXW11 FOSB FOSL2 GSK3B HNRNPR IRF2 JUN JUND KDM1A KEAP1 KPNA2 KPNA3 KPNA4 LEF1 MAFF MAFG MAFK MAP2K6 MAPK7 MAPK8 NCOR2 NFAT5 NFE2 NFE2L3 PAQR4 PMF1 PPARG PRKCA PRKCD RBMX REL RELA SMAD1 SP140 SPIC STAT3 SUMO1 SUMO2 TADA2A TBP TEF TIGAR TNNT1 TRIM24 TRIM41 USP11 USP8 WAC ZBTB24 ZNF396
Entrez ID		468	4780
HPRD ID		06817	02732
Ensembl ID		ENSG00000128272	ENSG00000116044
Uniprot IDs		P18848	A0A8V8TN14 A0A8V8TPA8 Q16236
PDB IDs		1CI6	2FLU 2LZ1 3ZGC 4IFL 5WFV 6T7V 7K28 7K29 7K2A 7K2B 7K2C 7K2D 7K2E 7K2K 7O7B 7X5E 7X5F 7X5G 8EJR 8EJS
Enriched GO Terms of Interacting Partners?		Integrated Stress Response Signaling RNA Polymerase II Transcription Regulator Complex Intracellular Signaling Cassette Chromatin DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Nucleus Sequence-specific Double-stranded DNA Binding DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Myeloid Cell Differentiation Negative Regulation Of RNA Metabolic Process Leukocyte Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Mononuclear Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Protein-DNA Complex Regulation Of Gene Expression Transcription By RNA Polymerase II CAMP Response Element Binding Protein Binding CHOP-C/EBP Complex N-terminal Peptidyl-lysine Acetylation Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Leucine Zipper Domain Binding Chromatin Binding Response To Nutrient Levels	Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Chromatin Nucleus Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm RNA Polymerase II Transcription Regulator Complex Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Integrated Stress Response Signaling Intracellular Signaling Cassette Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Transcription Cis-regulatory Region Binding Transcription By RNA Polymerase II Cellular Response To Stress Response To Stress Chromatin Binding Transcription Regulator Complex Cellular Response To Chemical Stress
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