ATF4 and RPS6

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ATF4	RPS6
Gene Name		activating transcription factor 4	ribosomal protein S6
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Microtubule Organizing Center Dendrite Membrane Nuclear Periphery Neuron Projection Lewy Body Core ATF1-ATF4 Transcription Factor Complex	Nucleus Nucleolus Cytoplasm Cytosol Polysome Small Ribosomal Subunit Membrane Cytosolic Small Ribosomal Subunit Dendrite Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Core Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Structural Constituent Of Ribosome Protein Binding Protein Kinase Binding Poly(A) RNA Binding
	Biological Process	Gluconeogenesis Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cellular Amino Acid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Gamma-aminobutyric Acid Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Endoplasmic Reticulum Unfolded Protein Response Circadian Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Cellular Response To Glucose Starvation Positive Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Ribosomal Small Subunit Assembly G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Placenta Development T Cell Proliferation Involved In Immune Response RRNA Processing Translation Translational Initiation Translational Elongation Translational Termination SRP-dependent Cotranslational Protein Targeting To Membrane Activation-induced Cell Death Of T Cells Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Gastrulation Insulin Receptor Signaling Pathway Gene Expression Viral Process Viral Life Cycle Viral Transcription Oogenesis Stage TOR Signaling T Cell Differentiation In Thymus Ribosomal Small Subunit Biogenesis Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Cellular Protein Metabolic Process Erythrocyte Development
Pathways		ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR)	Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling Peptide chain elongation IGF1R signaling cascade Influenza Life Cycle Formation of the ternary complex, and subsequently, the 43S complex IRS-related events triggered by IGF1R Influenza Viral RNA Transcription and Replication Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Nonsense-Mediated Decay (NMD) Insulin receptor signalling cascade Translation SRP-dependent cotranslational protein targeting to membrane S6K1 signalling Eukaryotic Translation Termination IRS-related events Influenza Infection Viral mRNA Translation L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling mTORC1-mediated signalling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits PKB-mediated events Eukaryotic Translation Elongation PI3K Cascade Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		65 interactors: APH1A APP ASB7 ATF2 ATF3 BATF BATF2 BATF3 BFSP2 BTRC CCDC106 CEBPA CEBPB CEBPE CEBPG CKAP4 CREB3 CREBZF DAPK3 DDIT3 DISC1 EGLN3 FOS FOSL1 GABBR2 GCC1 GOLGA1 GOLGA8EP GOLGA8F GPS2 GTF2A1L GTF2B GTF2F2 HAUS7 HK3 JUN JUNB KAT2B LDOC1 LMNB1 MAF MAFB MAP2K7 MDM2 MPZL2 NDC80 NEK6 NFE2 NFE2L1 NFE2L2 NFKBIA POLR2C PTCD3 REPS1 RPS6 SNAP29 SRA1 TBP TGM2 TREX2 TRIB3 TRIM24 TTR ZNF212 ZNF226	12 interactors: ATF4 NDRG1 OLFM2 PAK2 PLA2G12A PRKACB PRKCSH RPS4X RPS6KB1 RPS6KB2 STAU1 UPF2
Entrez ID		468	6194
HPRD ID		06817	01592
Ensembl ID		ENSG00000128272	ENSG00000137154
Uniprot IDs		P18848 Q96AQ3	A2A3R5 A2A3R6 P62753
PDB IDs		1CI6	3J3A
Enriched GO Terms of Interacting Partners?		Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Heterocycle Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Cellular Response To Stress Myeloid Cell Differentiation Leukocyte Differentiation Cellular Metabolic Process Response To Stress Apoptotic Process Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Organ Development Myeloid Leukocyte Differentiation Defense Response Programmed Cell Death Immune System Process Response To Stimulus Cell Death Death Hemopoiesis Response To External Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Positive Regulation Of Translation Positive Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Translational Initiation Protein Kinase B Signaling Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Translation Response To Glucagon Regulation Of Protein Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Innate Immune Response Response To Stress Response To Clozapine Regulation Of Translational Initiation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Skeletal Muscle Tissue Growth Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Protein Kinase Activity Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Positive Regulation By Virus Of Viral Protein Levels In Host Cell Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis Positive Regulation Of Kinase Activity Phosphatidylinositol-mediated Signaling Cellular Protein Metabolic Process Glucose Metabolic Process Positive Regulation Of Transferase Activity Skeletal Muscle Atrophy Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Nuclear-transcribed MRNA Catabolic Process RNA Localization Liver Development Carbohydrate Biosynthetic Process Cellular Response To Growth Factor Stimulus Immune System Process MRNA Catabolic Process Striated Muscle Atrophy Response To Leucine Immune Response Response To Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Protein Phosphorylation Defense Response Muscle Atrophy
Tagcloud ?		activates anticancer attenuated autophagy cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria mtorc1 nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3	acidified autophagy basally chloroquine chop compartments compensatory contrastingly employ endosomal entrapment exaggerated hyper inappropriate invoked lysosomal mechanistic mtorc1 nelfinavir normalised s6k1 signalling splicing sqtsm1 tolerated uncovered utilised whilst xbp1
Tagcloud (Difference) ?		activates anticancer attenuated cebpb chip ddit4 depletion effectively elusive exo genomic greatly largely mitochondria nude pad pan perturbation potentials remain resolution responsive sesn2 triple unveiled xenograft yw3	acidified basally chloroquine chop compartments compensatory contrastingly employ endosomal entrapment exaggerated hyper inappropriate invoked lysosomal mechanistic nelfinavir normalised s6k1 signalling splicing sqtsm1 tolerated uncovered utilised whilst xbp1
Tagcloud (Intersection) ?		autophagy mtorc1