PHYKPL and VAC14

Number of citations of the paper that reports this interaction (PubMedID 29892012)
71

Data Source:
BioGRID (two hybrid, two hybrid)

		PHYKPL	VAC14
Description		5-phosphohydroxy-L-lysine phospho-lyase	VAC14 component of PIKFYVE complex
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Golgi Membrane Endosome Endoplasmic Reticulum Cytosol Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane PAS Complex Presynaptic Endosome
	Molecular Function	Protein Binding Transaminase Activity Lyase Activity Pyridoxal Phosphate Binding Identical Protein Binding	Protein Binding Signaling Receptor Activity Identical Protein Binding
	Biological Process		Phosphatidylinositol Biosynthetic Process Signal Transduction Regulation Of Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Collagen degradation Lysine catabolism	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
Drugs		Pyridoxal phosphate Alanine
Diseases
GWAS			Diffuse cutaneous systemic sclerosis ( 29293537) Docetaxel-induced peripheral neuropathy in metastatic castrate-resistant prostate cancer ( 27143689) High density lipoprotein cholesterol levels ( 28548082) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Malaria ( 31844061) Pulse pressure ( 28135244)
Interacting Genes		4 interacting genes: LNX2 POT1 USO1 VAC14	107 interacting genes: ABHD11 ACSS1 ACTMAP AMT APP ARID5A ASB13 ATM BCL2L1 BHLHE40 BKGD C4orf33 CASP1 CATSPERT CD209 CDRT4 CNTN2 COL8A1 CRK CRYBA1 CRYBA2 DDAH2 DNAAF19 EEF1AKMT3 EHHADH EIF2S1 EIF6 FAM50B FNDC3B GABPB2 GALT GINS3 GLIS2 GNB1 GTF3C2 HDHD3 HNF1B HNRNPLL INTS11 JMJD7 KHDC1 KRABD5 KRT82 KRTAP15-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LINC00518 LPAL2 MBLAC1 MEOX2 METTL15 MGAT5B MPPED2 MTMR9 MVP MYOZ1 NDUFAB1 NGB NOS1 NTAQ1 OIT3 OTOS PBLD PCMTD2 PDE4DIP PELI1 PHF1 PHYKPL PIKFYVE PPP2CA PPP6C PRADC1 PRR13 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX2 RHBDL1 RHOXF2 RIPPLY1 RNASEH2C RSKR SIGLEC5 SMUG1 SNF8 SPMIP9 SPRYD7 SRPK2 TCEANC TP53BP1 TRIM55 TRIM63 UFSP1 VENTX VHLL WDR83 WRAP53 ZBTB49 ZCWPW1 ZNF34
Entrez ID		85007	55697
HPRD ID		18482	07660
Ensembl ID		ENSG00000175309	ENSG00000103043
Uniprot IDs		Q8IUZ5	Q08AM6
PDB IDs			7K1Y
Enriched GO Terms of Interacting Partners?		Golgi Vesicle Docking Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding PAS Complex Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Single-stranded Telomeric DNA Binding Vesicle Fusion With Golgi Apparatus Telomerase Inhibitor Activity Shelterin Complex Establishment Of Protein Localization To Telomere DEAD/H-box RNA Helicase Binding Presynaptic Endosome Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Regulation Of DNA Strand Elongation Transcytosis Secretory Granule Localization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Golgi Membrane Golgi Stack Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of DNA Biosynthetic Process	Protein Binding Intermediate Filament
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