EPHA7 and EFNA5

Number of citations of the paper that reports this interaction (PMID 10366629)
16

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		EPHA7	EFNA5
Gene Name		EPH receptor A7	ephrin-A5
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuromuscular Junction Neuronal Cell Body Postsynaptic Membrane	Extracellular Region Plasma Membrane Caveola Anchored Component Of External Side Of Plasma Membrane
	Molecular Function	Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Chemorepellent Activity Ephrin Receptor Binding	Chemorepellent Activity Ephrin Receptor Binding
	Biological Process	Axon Guidance Brain Development Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Protein Autophosphorylation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Branching Morphogenesis Of A Nerve Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of ERK1 And ERK2 Cascade	Apoptotic Process Nervous System Development Axon Guidance Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Rac GTPase Activity Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of Focal Adhesion Assembly Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Microtubule Cytoskeleton Organization
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Response to hepatitis C treatment ( 22095909)	Alzheimer's disease biomarkers ( 23419831) Hippocampal atrophy ( 19668339)
Protein-Protein Interactions		8 interactors: EFNA1 EFNA3 EFNA4 EFNA5 GNB1 MAP1LC3A MLLT4 ZNF267	10 interactors: EPHA2 EPHA3 EPHA4 EPHA5 EPHA7 EPHA8 EPHB1 EPHB2 GRIP1 SRC
Entrez ID		2045	1946
HPRD ID		03721	03324
Ensembl ID		ENSG00000135333	ENSG00000184349
Uniprot IDs		Q15375	P52803
PDB IDs		2REI 3DKO 3H8M 3NRU	2X11 3MX0 4BK5 4BKA
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Cell-cell Signaling Axon Guidance Response To External Stimulus Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Development Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Developmental Process Cell Morphogenesis Neuron Differentiation Cell Communication Cell Projection Organization Locomotion Cellular Response To Stimulus Movement Of Cell Or Subcellular Component Negative Regulation Of Dendritic Spine Morphogenesis Generation Of Neurons Positive Regulation Of Peptidyl-tyrosine Phosphorylation Multicellular Organismal Development Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Neurogenesis Anatomical Structure Development Cell Surface Receptor Signaling Pathway Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Mitral Valve Morphogenesis Negative Regulation Of Dendritic Spine Development Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Mitral Valve Development Establishment Of Endothelial Intestinal Barrier Cardiac Muscle Cell Apoptotic Process Cell Differentiation Muscle Cell Apoptotic Process Negative Regulation Of Dendrite Morphogenesis Signaling Response To Stimulus Peptidyl-tyrosine Phosphorylation Notochord Morphogenesis	Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Axon Guidance Neuron Projection Development Neuron Development Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Differentiation Neuron Projection Morphogenesis Cell Projection Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Peptidyl-amino Acid Modification Neurogenesis Cell Morphogenesis Cell Development Locomotion Protein Phosphorylation Nervous System Development Movement Of Cell Or Subcellular Component Response To External Stimulus Phosphorylation Cell Differentiation Anatomical Structure Morphogenesis System Development Regulation Of Intracellular Signal Transduction Retinal Ganglion Cell Axon Guidance Phosphate-containing Compound Metabolic Process Regulation Of MAPK Cascade Axonal Fasciculation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Multicellular Organismal Development Cellular Protein Modification Process Fasciculation Of Motor Neuron Axon Anatomical Structure Development Signal Transduction Neuron Recognition Central Nervous System Projection Neuron Axonogenesis Cell Migration Fasciculation Of Sensory Neuron Axon Developmental Process Cell Motility Signaling
Tagcloud ?		aberrations additional advances approaches biological closely contribute crebbp ep300 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique	adni apoe apolipoprotein arid1b bche butyrylcholinesterase c12orf75 cortical edil3 florbetapir gwas initiative itga1 itga6 largest load modifying neuroimaging nfib noninvasive nuak1 pik3r1 pivotal positron prohibited rs429358 rs509208 senile suggestive
Tagcloud (Difference) ?		aberrations additional advances approaches biological closely contribute crebbp ep300 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique	adni apoe apolipoprotein arid1b bche butyrylcholinesterase c12orf75 cortical edil3 florbetapir gwas initiative itga1 itga6 largest load modifying neuroimaging nfib noninvasive nuak1 pik3r1 pivotal positron prohibited rs429358 rs509208 senile suggestive
Tagcloud (Intersection) ?