EPHA7 and GNB1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EPHA7	GNB1
Gene Name		EPH receptor A7	guanine nucleotide binding protein (G protein), beta polypeptide 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuromuscular Junction Neuronal Cell Body Postsynaptic Membrane	Photoreceptor Inner Segment Intracellular Lysosomal Membrane Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Vesicle Photoreceptor Outer Segment Membrane Cell Body Extracellular Vesicular Exosome Photoreceptor Disc Membrane
	Molecular Function	Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Chemorepellent Activity Ephrin Receptor Binding	GTPase Activity Signal Transducer Activity Protein Binding Spectrin Binding Type 1 Angiotensin Receptor Binding Protein Complex Binding GTPase Binding
	Biological Process	Axon Guidance Brain Development Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Protein Autophosphorylation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Branching Morphogenesis Of A Nerve Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of ERK1 And ERK2 Cascade	Energy Reserve Metabolic Process Signal Transduction Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration G-protein Coupled Acetylcholine Receptor Signaling Pathway Ras Protein Signal Transduction Synaptic Transmission Blood Coagulation Phototransduction, Visible Light Cell Proliferation Cardiac Muscle Cell Apoptotic Process Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Platelet Activation Small Molecule Metabolic Process Sensory Perception Of Taste Retina Development In Camera-type Eye Cellular Response To Glucagon Stimulus Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Cellular Response To Catecholamine Stimulus
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Olfactory Signaling Pathway Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Diseases associated with visual transduction Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G beta:gamma signalling through PI3Kgamma The phototransduction cascade G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Visual phototransduction Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Response to hepatitis C treatment ( 22095909)
Protein-Protein Interactions		8 interactors: EFNA1 EFNA3 EFNA4 EFNA5 GNB1 MAP1LC3A MLLT4 ZNF267	43 interactors: ADRA2A ADRB2 ADRBK1 AFP ARHGEF18 ARRB1 ATXN10 AVPR2 CACNA1A CACNA1B CACNA1C CYFIP1 DISC1 EPHA7 GNA12 GNAS GNB2L1 GNG10 GNG11 GNG12 GNG13 GNG2 GNG3 GNG4 GNG5 GNG7 GNG8 GNGT1 HDAC4 HDAC5 KCNJ3 MCF2 MRGPRX1 MTNR1A MTNR1B NOL11 NR3C1 PDCL PLEKHG2 PTH1R RASD1 RASD2 TBXA2R
Entrez ID		2045	2782
HPRD ID		03721	00766
Ensembl ID		ENSG00000135333	ENSG00000078369
Uniprot IDs		Q15375	P62873
PDB IDs		2REI 3DKO 3H8M 3NRU	4KFM
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Cell-cell Signaling Axon Guidance Response To External Stimulus Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Development Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Developmental Process Cell Morphogenesis Neuron Differentiation Cell Communication Cell Projection Organization Locomotion Cellular Response To Stimulus Movement Of Cell Or Subcellular Component Negative Regulation Of Dendritic Spine Morphogenesis Generation Of Neurons Positive Regulation Of Peptidyl-tyrosine Phosphorylation Multicellular Organismal Development Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Neurogenesis Anatomical Structure Development Cell Surface Receptor Signaling Pathway Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Mitral Valve Morphogenesis Negative Regulation Of Dendritic Spine Development Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Mitral Valve Development Establishment Of Endothelial Intestinal Barrier Cardiac Muscle Cell Apoptotic Process Cell Differentiation Muscle Cell Apoptotic Process Negative Regulation Of Dendrite Morphogenesis Signaling Response To Stimulus Peptidyl-tyrosine Phosphorylation Notochord Morphogenesis	Cellular Response To Glucagon Stimulus Signaling Cell Communication Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Response To Glucagon Signal Transduction Cell Surface Receptor Signaling Pathway Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Stimulus Response To Stimulus Generation Of Precursor Metabolites And Energy Cellular Response To Hormone Stimulus Synaptic Transmission Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Response To Peptide G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cellular Process Response To Peptide Hormone Cell-cell Signaling Cellular Response To Organonitrogen Compound Response To Hormone Cellular Response To Organic Substance Response To Organic Substance Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Response To Organonitrogen Compound Regulation Of Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Metabolic Process Regulation Of Adenylate Cyclase Activity Regulation Of Signal Transduction Regulation Of Cyclase Activity Oxidation-reduction Process Regulation Of Muscle Contraction Positive Regulation Of Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Multicellular Organismal Response To Stress Regulation Of CAMP Biosynthetic Process Platelet Activation Regulation Of Insulin Secretion Chemical Homeostasis Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Peptide Hormone Secretion Cellular Process Adrenergic Receptor Signaling Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Vasoconstriction Small Molecule Metabolic Process
Tagcloud ?		aberrations additional advances approaches biological closely contribute crebbp ep300 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique	abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb2 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants
Tagcloud (Difference) ?		aberrations additional advances approaches biological closely contribute crebbp ep300 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique	abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb2 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants
Tagcloud (Intersection) ?