EPHA7 and EFNA1

Number of citations of the paper that reports this interaction (PMID 8755474)
133

Data Source:
HPRD (in vitro)

		EPHA7	EFNA1
Gene Name		EPH receptor A7	ephrin-A1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Neuromuscular Junction Neuronal Cell Body Postsynaptic Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Anchored Component Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Kinase Activity GPI-linked Ephrin Receptor Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Chemorepellent Activity Ephrin Receptor Binding	Receptor Binding Protein Binding Ephrin Receptor Binding
	Biological Process	Axon Guidance Brain Development Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Cell-cell Adhesion Retinal Ganglion Cell Axon Guidance Regulation Of Protein Autophosphorylation Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Ephrin Receptor Signaling Pathway Branching Morphogenesis Of A Nerve Regulation Of Peptidyl-tyrosine Phosphorylation Negative Chemotaxis Regulation Of ERK1 And ERK2 Cascade	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of MAPK Activity Angiogenesis Aortic Valve Morphogenesis Mitral Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Cell-cell Signaling Axon Guidance Negative Regulation Of Epithelial To Mesenchymal Transition Notochord Formation Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Ephrin Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Axonogenesis Negative Regulation Of Dendritic Spine Morphogenesis
Pathways		EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling	EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Response to hepatitis C treatment ( 22095909)	Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Obesity-related traits ( 23251661) Prostate cancer ( 23535732)
Protein-Protein Interactions		8 interactors: EFNA1 EFNA3 EFNA4 EFNA5 GNB1 MAP1LC3A MLLT4 ZNF267	14 interactors: ADAM10 EEF1G EPHA1 EPHA2 EPHA3 EPHA4 EPHA5 EPHA6 EPHA7 EPHA8 EPHB1 KAT5 PPBP XRCC6
Entrez ID		2045	1942
HPRD ID		03721	01858
Ensembl ID		ENSG00000135333	ENSG00000169242
Uniprot IDs		Q15375	P20827
PDB IDs		2REI 3DKO 3H8M 3NRU	3CZU 3HEI 3MBW
Enriched GO Terms of Interacting Partners?		Ephrin Receptor Signaling Pathway Cell-cell Signaling Axon Guidance Response To External Stimulus Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cell Development Enzyme Linked Receptor Protein Signaling Pathway Neuron Development Developmental Process Cell Morphogenesis Neuron Differentiation Cell Communication Cell Projection Organization Locomotion Cellular Response To Stimulus Movement Of Cell Or Subcellular Component Negative Regulation Of Dendritic Spine Morphogenesis Generation Of Neurons Positive Regulation Of Peptidyl-tyrosine Phosphorylation Multicellular Organismal Development Endocardial Cushion To Mesenchymal Transition Involved In Heart Valve Formation Neurogenesis Anatomical Structure Development Cell Surface Receptor Signaling Pathway Aortic Valve Morphogenesis Endocardial Cushion To Mesenchymal Transition Notochord Formation Mitral Valve Morphogenesis Negative Regulation Of Dendritic Spine Development Signal Transduction Regulation Of Peptidyl-tyrosine Phosphorylation Mitral Valve Development Establishment Of Endothelial Intestinal Barrier Cardiac Muscle Cell Apoptotic Process Cell Differentiation Muscle Cell Apoptotic Process Negative Regulation Of Dendrite Morphogenesis Signaling Response To Stimulus Peptidyl-tyrosine Phosphorylation Notochord Morphogenesis	Ephrin Receptor Signaling Pathway Chemotaxis Axon Guidance Peptidyl-tyrosine Phosphorylation Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Locomotion Cell Part Morphogenesis Response To External Stimulus Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-amino Acid Modification Neuron Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Generation Of Neurons Neuron Differentiation Neurogenesis Cell Projection Organization Protein Phosphorylation Nervous System Development Cell Development Phosphorylation Cell Surface Receptor Signaling Pathway Cellular Protein Modification Process Anatomical Structure Morphogenesis Cellular Protein Metabolic Process Cell Differentiation Regulation Of Rac GTPase Activity Fasciculation Of Motor Neuron Axon Regulation Of Rho GTPase Activity Response To Stimulus Phosphate-containing Compound Metabolic Process Cellular Response To Stimulus Regulation Of Cell Adhesion Signal Transduction Regulation Of Rac Protein Signal Transduction Fasciculation Of Sensory Neuron Axon Regulation Of Rho Protein Signal Transduction System Development Protein Metabolic Process Regulation Of Intracellular Signal Transduction Signaling Cell Communication Multicellular Organismal Development
Tagcloud ?		aberrations additional advances approaches biological closely contribute crebbp ep300 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique	abcc3 abcc5 amphiregulin areg ccna2 csta ctsd cycloheximide dissimilar dleu2 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217
Tagcloud (Difference) ?		aberrations additional advances approaches biological closely contribute crebbp ep300 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique	abcc3 abcc5 amphiregulin areg ccna2 csta ctsd cycloheximide dissimilar dleu2 estrogens hydroxytamoxifen ici igfbp4 irs1 mini mmp15 mvln pcna permit regulations reinforced rtq secondly tacc1 tam tff1 ugt1a1 znf217
Tagcloud (Intersection) ?