FBH1

Description		F-box DNA helicase 1
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GO Annotations	Cellular Component	Chromatin Nucleus Chromosome SCF Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Double-stranded DNA Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding DNA Translocase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Protein Phosphorylation DNA Repair DNA Catabolic Process DNA Damage Response Protein Ubiquitination Replication Fork Processing Response To Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways
Drugs
Diseases
GWAS
Interacting Genes		12 interacting genes: CUL1 DSCR9 ESR1 PCNA PIM2 RAD51 RBX1 RNF20 RPL13A SKP1 UBC ZDHHC17
Entrez ID		84893
HPRD ID		06243
Ensembl ID		ENSG00000134452
Uniprot IDs		B3KV95 F6UZG9 Q2TAK1 Q8NFZ0
PDB IDs		8F5Q
Enriched GO Terms of Interacting Partners?		Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Cul7-RING Ubiquitin Ligase Complex Macromolecule Metabolic Process Protein Monoubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Modification-dependent Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Protein Modification Process Protein Ubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Cullin-RING Ubiquitin Ligase Complex Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation DNA Polymerase Binding Cullin Family Protein Binding Mitotic Cell Cycle Phase Transition Post-translational Protein Modification Cell Cycle Phase Transition Protein Metabolic Process Cellular Response To Radiation Positive Regulation Of Autophagy Regulation Of Programmed Cell Death Chromatin Binding Nuclear Estrogen Receptor Binding Replication Fork Processing Cellular Response To Oxidative Stress Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Male Germ Cell Nucleus PCNA Complex Replisome Response To Glucoside Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Formation Of Translation Preinitiation Complex Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Cellular Response To Chemical Stress Proteolysis Lysosome Organization TORC1 Signaling Negative Regulation Of TORC1 Signaling Catabolic Process
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