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FBXO18 and RBX1
Number of citations of the paper that reports this interaction (PMID
11956208
)
25
Data Source:
BioGRID
(pull down)
HPRD
(in vivo)
FBXO18
RBX1
Gene Name
F-box protein, helicase, 18
ring-box 1, E3 ubiquitin protein ligase
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
VCB Complex
Cullin-RING Ubiquitin Ligase Complex
Cul2-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4B-RING E3 Ubiquitin Ligase Complex
Cul5-RING Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
Molecular Function
DNA Binding
ATP-dependent DNA Helicase Activity
Protein Binding
ATP Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
NEDD8 Transferase Activity
Ubiquitin Protein Ligase Binding
Protein Complex Binding
Ubiquitin-ubiquitin Ligase Activity
Ubiquitin Protein Ligase Activity
Cullin Family Protein Binding
Biological Process
DNA Catabolic Process, Endonucleolytic
Positive Regulation Of Protein Phosphorylation
DNA Duplex Unwinding
Response To Intra-S DNA Damage Checkpoint Signaling
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
DNA Repair
Protein Monoubiquitination
Notch Signaling Pathway
Viral Process
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Neddylation
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Response To Hypoxia
Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Vif-mediated degradation of APOBEC3G
Signaling by NOTCH1 HD Domain Mutants in Cancer
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Degradation of beta-catenin by the destruction complex
RNF mutants show enhanced WNT signaling and proliferation
AXIN mutants destabilize the destruction complex, activating WNT signaling
S33 mutants of beta-catenin aren't phosphorylated
Signaling by NOTCH1 in Cancer
Prolactin receptor signaling
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
Signaling by NOTCH
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Signaling by ERBB4
Signaling by Interleukins
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Interleukin-1 signaling
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Adaptive Immune System
Cellular response to hypoxia
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
HIV Infection
APC truncation mutants have impaired AXIN binding
APC truncation mutants are not K63 polyubiquitinated
S37 mutants of beta-catenin aren't phosphorylated
Hedgehog 'on' state
Signaling by NOTCH1
XAV939 inhibits tankyrase, stabilizing AXIN
Class I MHC mediated antigen processing & presentation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FBXW7 Mutants and NOTCH1 in Cancer
Cytokine Signaling in Immune system
Nuclear signaling by ERBB4
NOTCH1 Intracellular Domain Regulates Transcription
TCF dependent signaling in response to WNT
Signaling by Hedgehog
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Degradation of GLI1 by the proteasome
degradation of DVL
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS
Breast cancer (
20453838
)
Crohn's disease (
22936669
)
Protein-Protein Interactions
8 interactors:
CUL1
PIM2
RAD51
RBX1
RPL13A
SKP1
UBC
ZDHHC17
58 interactors:
APP
BRCA1
CAND1
CCND1
CCNE1
CDC34
COPS6
CSNK1E
CTNNB1
CUL1
CUL3
CUL4A
CUL4B
CUL5
CUL7
DDB1
FBXO18
FBXW8
FRZB
GLMN
GPS1
HAX1
HIST1H1C
MAP3K7
MAPK8IP2
MKNK2
MYB
NFKBIA
OS9
PLK1
PML
PRAME
RHOBTB3
RNF126
RPS6KB1
SAMHD1
SERTAD1
SKP1
SMAD3
TAB1
TP73
TRIM27
TRIM74
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2M
UBE2R2
VHL
VPRBP
VRK2
WNK1
ZAK
Entrez ID
84893
9978
HPRD ID
06243
06794
Ensembl ID
ENSG00000134452
Uniprot IDs
B3KV95
Q2TAK1
Q8NFZ0
P62877
PDB IDs
1LDJ
1LDK
1U6G
2HYE
2LGV
3DPL
3DQV
3RTR
4F52
Enriched GO Terms of Interacting Partners
?
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Notch Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Protein Monoubiquitination
Viral Process
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Cellular Macromolecule Catabolic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
G2/M Transition Of Mitotic Cell Cycle
Cell Cycle Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Circadian Rhythm
Protein Ubiquitination
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Cell Cycle
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Catabolic Process
Mitotic Cell Cycle Process
Cellular Protein Metabolic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Mitotic Cell Cycle
Positive Regulation Of Proteolysis
Rhythmic Process
Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Cellular Protein Modification Process
Regulation Of DNA-templated Transcription In Response To Stress
Response To Stimulus
Regulation Of Protein Catabolic Process
Protein Metabolic Process
Negative Regulation Of Formation Of Translation Preinitiation Complex
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Regulation Of Protein Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Protein Catabolic Process
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Cellular Protein Metabolic Process
Cellular Macromolecule Catabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Metabolic Process
Proteasomal Protein Catabolic Process
Cell Cycle Process
Cellular Response To Stimulus
Cell Cycle
Regulation Of Cell Cycle
Cell Cycle Phase Transition
Positive Regulation Of Cellular Metabolic Process
Regulation Of Phosphorylation
Protein Monoubiquitination
Cellular Response To Stress
Cellular Metabolic Process
Response To Stress
Regulation Of Mitotic Cell Cycle
Regulation Of Phosphorus Metabolic Process
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Protein Modification Process
Proteolysis
Regulation Of Protein Phosphorylation
Mitotic Cell Cycle Process
G1/S Transition Of Mitotic Cell Cycle
Catabolic Process
Response To Stimulus
Positive Regulation Of Metabolic Process
Mitotic Cell Cycle
Negative Regulation Of Cell Cycle
Regulation Of Cell Cycle Process
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Protein Kinase Activity
Signal Transduction
Cell Death
Regulation Of Cell Cycle Phase Transition
Death
Tagcloud
?
adrenal
arise
bc
chromaffin
cnl
copy
cul2
disrupting
elongin
enrichment
harbored
heterozygosity
hif1
hif1a
hippel
hypoxic
indeed
inherited
lindau
merit
normoxic
pcc
pheochromocytomas
predisposing
pseudohypoxic
tceb1
tceb2
vhl
von
Tagcloud (Difference)
?
adrenal
arise
bc
chromaffin
cnl
copy
cul2
disrupting
elongin
enrichment
harbored
heterozygosity
hif1
hif1a
hippel
hypoxic
indeed
inherited
lindau
merit
normoxic
pcc
pheochromocytomas
predisposing
pseudohypoxic
tceb1
tceb2
vhl
von
Tagcloud (Intersection)
?